Results 51 to 60 of about 732 (118)

Plasma 24-hydroxycholesterol is associated with narrower common carotid artery and greater flow velocities in relapsing multiple sclerosis

Veins and Lymphatics, 2022
Background: Multiple sclerosis (MS) studies suggest greater cardiovascular disease burden and disturbances in the cholesterol pathways1,2 The potential impact of oxidized cholesterol molecules (oxysterols) on MS is emerging (Figure 1).3 Objective: To
Dejan Jakimovski, Robert Zivadinov, Laura Pelizzari, Cynthia Dunne-Jaffe, Richard W. Browne, Niels Bergsland, Michael G. Dwyer, Bianca Weinstock-Guttman, Murali Ramanathan   +8 more
doaj   +1 more source

Fish Cholesterol 25-Hydroxylase Inhibits Virus Replication via Regulating Interferon Immune Response or Affecting Virus Entry

Frontiers in Immunology, 2019
Cholesterol 25-hydroxylase (CH25H) is an interferon (IFN)-induced gene that catalyzes the oxidation of cholesterol to 25-hydroxycholesterol (25HC), which exerts broad-spectrum antiviral function.
Ya Zhang, Liqun Wang, Liqun Wang, Xiaohong Huang, Shaowen Wang, Youhua Huang, Qiwei Qin, Qiwei Qin   +7 more
doaj   +1 more source

Role of cholesterol in modulating brain hyperexcitability

Epilepsia, Volume 66, Issue 1, Page 33-46, January 2025.
Abstract Cholesterol is a critical molecule in the central nervous system, and imbalances in the synthesis and metabolism of brain cholesterol can result in a range of pathologies, including those related to hyperexcitability. The impact of cholesterol on disorders of epilepsy and developmental and epileptic encephalopathies is an area of growing ...
James W. Wheless, Jong M. Rho
wiley   +1 more source

Investigation on Cooling Performance of Composite PCM and Graphite Fin for Battery Thermal Management System of Electric Vehicles

Energy Storage, Volume 6, Issue 6, September 2024.
ABSTRACT Modern electric vehicle (EV) batteries need phase change materials (PCM) that are capable of efficient battery cooling. In this work, a composite PCM is prepared by mixing Fe3O4 nanoparticles (1 wt.%) in paraffin, and the effects of these nanoparticles on the enthalpy and melting point of PCM are studied.
Nikhil S. Mane, Pradyumna Kodancha, Vadiraj Hemadri, Siddhartha Tripathi   +3 more
wiley   +1 more source

Cholesterol 25‐Hydroxylase Protects Against Diabetic Kidney Disease by Regulating ADP Ribosylation Factor 4

Advanced Science, Volume 11, Issue 29, August 7, 2024.
This study shows that cholesterol 25‐hydroxylase (CH25H), a key enzyme in cholesterol metabolism, is expressed in kidney endothelial cells and protects against diabetic kidney disease. Its product, 25‐HC, binds to and enhances the activity of GTP‐binding protein ADP‐ribosylation factor 4 (ARF4), an essential protein required for Golgi trafficking and ...
Lu Zhang, Zhengying Fang, Qingqing Zhu, Shumin Yang, Jia Fu, Zeguo Sun, Geming Lu, Chengguo Wei, Zhi Zhang, Kyung Lee, Yifei Zhong, Ruijie Liu, John Cijiang He   +12 more
wiley   +1 more source

Inhibition of herpes simplex-1 virus replication by 25-hydroxycholesterol and 27-hydroxycholesterol

Redox Biology, 2017
Oxysterols are known pleiotropic molecules whose antiviral action has been recently discovered. Here reported is the activity of a panel of oxysterols against HSV-1 with the identification of a new mechanism of action.
Valeria Cagno, Andrea Civra, Daniela Rossin, Simone Calfapietra, Claudio Caccia, Valerio Leoni, Nicholas Dorma, Fiorella Biasi, Giuseppe Poli, David Lembo   +9 more
doaj   +1 more source

Molecular mechanism of renal lipid accumulation in diabetic kidney disease

Journal of Cellular and Molecular Medicine, Volume 28, Issue 11, June 2024.
Abstract Diabetic kidney disease (DKD) is a leading cause of end stage renal disease with unmet clinical demands for treatment. Lipids are essential for cell survival; however, renal cells have limited capability to metabolize overloaded lipids. Dyslipidaemia is common in DKD patients and renal ectopic lipid accumulation is associated with disease ...
Zhengying Fang, Ruijie Liu, Jingyuan Xie, John Cijiang He   +3 more
wiley   +1 more source

Reprogramming of the LXRα Transcriptome Sustains Macrophage Secondary Inflammatory Responses

Advanced Science, Volume 11, Issue 20, May 28, 2024.
The inflammatory response is a defense mechanism of the innate immune system against infections and other injuries. In response to microbial components, macrophages activate primary and secondary inflammatory gene programs crucial for host defense. De la Rosa et al. provide evidence that inflammation triggers a reprogramming of the transcription factor
Juan Vladimir de la Rosa, Carlos Tabraue, Zhiqiang Huang, Marta C. Orizaola, Patricia Martin‐Rodríguez, Knut R. Steffensen, Juan Manuel Zapata, Lisardo Boscá, Peter Tontonoz, Susana Alemany, Eckardt Treuter, Antonio Castrillo   +11 more
wiley   +1 more source

Oxysterols and apolipoproteins in multiple sclerosis: a 5 year follow-up study[S]

Journal of Lipid Research, 2019
The purpose of this work was to investigate whether changes in oxysterol and apolipoprotein levels over 5 years are associated with disease course and disability progression in multiple sclerosis (MS).
Kelly Fellows Maxwell, Sonia Bhattacharya, Mary Lou Bodziak, Dejan Jakimovski, Jesper Hagemeier, Richard W. Browne, Bianca Weinstock-Guttman, Robert Zivadinov, Murali Ramanathan   +8 more
doaj   +1 more source

Cholesterol-25-hydroxylase Is a Chicken ISG That Restricts ALV-J Infection by Producing 25-hydroxycholesterol

Viruses, 2019
The avian leukosis virus subgroup J (ALV-J) belongs to the chicken retrovirus that causes enormous economic losses in the poultry industry. Interferon-stimulated genes (ISGs) are critical for controlling virus infections.
Tingting Xie, Min Feng, Manman Dai, Guodong Mo, Zhuohao Ruan, Guiyan Wang, Meiqing Shi, Xiquan Zhang   +7 more
doaj   +1 more source