Results 31 to 40 of about 732 (118)

Nuclear Oxysterols, 25HC and 25HC3S, Regulate Nuclear Orphan Receptor Activities and Attenuate Intracellular Lipid Levels

The FASEB Journal, 2009
We recently identified the sulfated oxysterol, 5‐cholesten‐3beta, 25‐diol 3‐sulfate (25HC3S), as an important regulatory molecule. When cholesterol delivered to mitochondria was increased by overexpression of the transport protein StarD1 in primary rat hepatocytes, 25‐Hydroxycholesterol (25HC) and 25HC3S were ...
Leyuan Xu, Yongjie Ma, Phillip Hylemon, Douglas Heuman, William Pandak, Shunlin Ren   +5 more
openaire   +1 more source

Development trends of human organoid‐based COVID‐19 research based on bibliometric analysis

Cell Proliferation, Volume 56, Issue 12, December 2023., 2023
Keyword co‐occurrence overlay visualization of the research of organoids for SARS‐CoV‐2 infection. More studies focused on pulmonary infection using organoid models at the early stages of the COVID‐19 pandemic. Recently, keywords included ‘drug repurposing’, ‘personalized medicine’, ‘repair’, ‘therapy’, ‘resistance’ and ‘therapeutics’ are more popular.
Minghui Li, Yuhan Yuan, Ting Zou, Zongkun Hou, Liang Jin, Bochu Wang   +5 more
wiley   +1 more source

RORα and 25-Hydroxycholesterol Crosstalk Regulates Lipid Droplet Homeostasis in Macrophages. [PDF]

PLoS ONE, 2016
Nuclear hormone receptors have important roles in the regulation of metabolic and inflammatory pathways. The retinoid-related orphan receptor alpha (Rorα)-deficient staggerer (sg/sg) mice display several phenotypes indicative of aberrant lipid metabolism,
Zewen Kelvin Tuong, Patrick Lau, Ximing Du, Nicholas D Condon, Joel M Goode, Tae Gyu Oh, Jeremy C Yeo, George E O Muscat, Jennifer L Stow   +8 more
doaj   +1 more source

Chicken CH25H inhibits ALV-J replication by promoting cellular autophagy

Frontiers in Immunology, 2023
Autophagy plays an important role in host antiviral defense. The avian leukosis virus subgroup J (ALV-J) has been shown to inhibit autophagy while promoting viral replication. The underlying autophagic mechanisms, however, are unknown.
Tingting Xie, Tingting Xie, Tingting Xie, Min Feng, Xi Zhang, Xi Zhang, Xi Zhang, Xiaoqi Li, Xiaoqi Li, Xiaoqi Li, Guodong Mo, Guodong Mo, Guodong Mo, Meiqing Shi, Xiquan Zhang, Xiquan Zhang, Xiquan Zhang   +16 more
doaj   +1 more source

Strategies for senolytic drug discovery

Aging Cell, Volume 22, Issue 10, October 2023., 2023
Senolytics are a category of drugs that reduce the impact of cellular senescence, an effect associated with a range of chronic and age‐related diseases. This review discusses current senolytics and screening approaches for identifying novel active compounds.
Helen Power, Peter Valtchev, Fariba Dehghani, Aaron Schindeler   +3 more
wiley   +1 more source

Activation of liver X receptor plays a central role in antiviral actions of 25-hydroxycholesterol

Journal of Lipid Research, 2018
Production of 25-hydroxycholesterol (25HC), a potent inhibitor of viral infection, is catalyzed by cholesterol 25-hydroxylase (CH25H). We previously reported that 25HC induced CH25H expression in a liver X receptor (LXR)-dependent manner, implying that ...
Ying Liu, Zhuo Wei, Ye Zhang, Xingzhe Ma, Yuanli Chen, Miao Yu, Chuanrui Ma, Xiaoju Li, Youjia Cao, Jian Liu, Jihong Han, Xiaoxiao Yang, Yajun Duan   +12 more
doaj   +1 more source

Antiviral Actions of 25-Hydroxycholesterol in Fish Vary With the Virus-Host Combination

Frontiers in Immunology, 2021
Cholesterol is essential for building and maintaining cell membranes and is critical for several steps in the replication cycle of viruses, especially for enveloped viruses. In mammalian cells virus infections lead to the accumulation of the oxysterol 25-
Mikolaj Adamek, Jonathan Davies, Jonathan Davies, Alexander Beck, Lisa Jordan, Anna M. Becker, Miriam Mojzesz, Krzysztof Rakus, Typhaine Rumiac, Bertrand Collet, Graham Brogden, Graham Brogden, Graham Brogden, Keith Way, Sven M. Bergmann, Jun Zou, Jun Zou, Jun Zou, Jun Zou, Dieter Steinhagen   +19 more
doaj   +1 more source

Phenotypic switch of vascular smooth muscle cells in COVID-19: Role of cholesterol, calcium, and phosphate. [PDF]

J Cell Physiol
Abstract Although the novel coronavirus disease 2019 (COVID‐19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), primarily manifests as severe respiratory distress, its impact on the cardiovascular system is also notable. Studies reveal that COVID‐19 patients often suffer from certain vascular diseases, partly attributed to ...
Ghanem L, Essayli D, Kotaich J, Zein MA, Sahebkar A, Eid AH.   +5 more
europepmc   +2 more sources

25-Hydroxycholesterol Inhibition of Lassa Virus Infection through Aberrant GP1 Glycosylation

mBio, 2016
Lassa virus (LASV) infection is a major public health concern due to high fatality rates and limited effective treatment. The interferon-stimulated gene cholesterol 25-hydroxylase (CH25H) encodes an enzyme that catalyzes the production of 25 ...
Punya Shrivastava-Ranjan, Éric Bergeron, Ayan K. Chakrabarti, César G. Albariño, Mike Flint, Stuart T. Nichol, Christina F. Spiropoulou   +6 more
doaj   +1 more source

Biosynthesis of the regulatory oxysterol, 5-cholesten-3β,25-diol 3-sulfate, in hepatocytes

Journal of Lipid Research, 2007
Cellular cholesterol homeostasis is maintained through coordinated regulation of cholesterol synthesis, degradation, and secretion. Nuclear receptors for oxygenated cholesterol derivatives (oxysterols) are known to play key roles in the regulation of ...
Xiaobo Li, William M. Pandak, Sandra K. Erickson, Yongjie Ma, Lianhua Yin, Phillip Hylemon, Shunlin Ren   +6 more
doaj   +1 more source