Results 11 to 20 of about 732 (118)

Advances in the Prevention of Cervical Cancer by Anti‐Human Papillomavirus Agents [PDF]

Cancer Medicine
Background Cervical cancer remains a major global health threat for women, primarily driven by human papillomavirus (HPV) infection. While HPV vaccination serves as the cornerstone of prevention, disparities in vaccine accessibility persist across low ...
Hangdi Chen, Kai Guo, Zhihao Bai, Liuyi Lu, Bin Liu, Jiali Zhang, Meiyin Zhong, Changfen Xu, Wanghuan Chen, Aiwu Huang, Yuemin Ding   +10 more
doaj   +3 more sources

25-Hydroxycholesterol Restricts Japanese Encephalitis Virus via Metabolic Suppression of the SREBP2-Mediated Signaling Axis [PDF]

Microorganisms
Host lipid metabolism is a critical determinant of viral pathogenesis. Although the interferon-inducible cholesterol 25-hydroxylase (CH25H) typically acts as a broad-spectrum antiviral protein, its expression and regulatory patterns during Japanese ...
Xinlei Liu, Yu Gu, Yuanyuan Yang, Xinran Li, Yu Dai, Ruiqin Zhang, Jiahui Li, Haodong Chen, Yi Zheng, Rui Wu   +9 more
doaj   +2 more sources

Cholesterol 25-hydroxylase suppresses avian reovirus replication by its enzymatic product 25-hydroxycholesterol [PDF]

Frontiers in Microbiology, 2023
Avian reovirus (ARV) causing viral arthritis/tenosynovitis and viral enteritis in domestic fowl has significantly threatened on the poultry industry worldwide. ARV is a non-enveloped fusogenic virus that belongs to the Reoviridae family.
Yuyang Wang, Yuyang Wang, Wei Zuo, Yangyang Zhang, Zongyi Bo, Zongyi Bo, Chengcheng Zhang, Xiaorong Zhang, Yantao Wu, Yantao Wu   +9 more
doaj   +2 more sources

A CRISPR activation screen identifies CH25H as a restriction factor against influenza viruses by targeting accessible cholesterol [PDF]

Emerging Microbes and Infections
Influenza A viruses (IAVs) cause severe outbreaks with high mortality in birds and humans. A deeper understanding of cell-intrinsic defense mechanisms against influenza viruses is therefore crucial for developing novel antiviral strategies.
Jinyu Huang, Kaixiong Ma, Shiping Ding, Yunmeng Wang, Junlong Xiong, Jiahui Yi, Jiahao Zhang, Zhuoliang He, Lihong Huang, Xingxing Ren, Jiangtao Zhou, Xiaona Chen, Lele Liu, Wenbao Qi, Shaobo Wang, Ming Liao   +15 more
doaj   +2 more sources

25-hydroxycholesterol promotes brain cytokine production and leukocyte infiltration in a mouse model of lipopolysaccharide-induced neuroinflammation [PDF]

Journal of Neuroinflammation
Neuroinflammation has been implicated in the pathogenesis of several neurologic and psychiatric disorders. Microglia are key drivers of neuroinflammation and, in response to different inflammatory stimuli, overexpress a proinflammatory signature of genes.
Johnathan Romero, Danira Toral-Rios, Jinsheng Yu, Steven M. Paul, Anil G. Cashikar   +4 more
doaj   +2 more sources

Dual-Role of Cholesterol‐25‐Hydroxylase in Regulating Hepatitis B Virus Infection and Replication

MBio, 2022
Hepatitis B virus (HBV)‐related diseases are among the major diseases that affect millions of people worldwide. These diseases are difficult to eradicate and thus pose a serious global health challenge.
Hongxiao Song, Fengchao Xu, Qingfei Xiao   +2 more
exaly   +3 more sources

Cholesterol 25-hydroxylase inhibits Newcastle disease virus replication by enzyme activity-dependent and direct interaction with nucleocapsid protein [PDF]

Journal of Virology
Newcastle disease virus (NDV) is a significant enveloped virus within the Paramyxoviridae family, posing a major threat to the global poultry industry.
Guangmei Zhu, Xianchun Zong, Mengmeng Xiao, Dan Wang, Zhe Xu, Jingtao Hu, Guilian Yang, Yanlong Jiang, Wentao Yang, Haibin Huang, Chunwei Shi, Yan Zeng, Nan Wang, Xin Cao, Jianzhong Wang, Chunfeng Wang   +15 more
doaj   +2 more sources

Cholesterol inhibition enhances antitumor response of gilteritinib in lung cancer cells [PDF]

Cell Death and Disease
Repositioning approved antitumor drugs for different cancers is a cost-effective approach. Gilteritinib was FDA-approved for the treatment of FLT3-mutated acute myeloid leukemia in 2018.
Chao-Yue Sun, Di Cao, Yue-Ning Wang, Nuo-Qing Weng, Qian-Nan Ren, Shuo-Cheng Wang, Mei-Yin Zhang, Shi-Juan Mai, Hui-Yun Wang   +8 more
doaj   +2 more sources

Liver specific transgenic expression of CYP7B1 attenuates early western diet-induced MASLD progression [PDF]

Journal of Lipid Research
Effect of liver specific oxysterol 7α-hydroxylase (CYP7B1) overexpression on the Western diet (WD)-induced metabolic dysfunction-associated steatotic liver disease (MASLD) progression was studied in mice. Among various hepatic genes impacted during MASLD
Genta Kakiyama, Nanah Bai-Kamara, Daniel Rodriguez-Agudo, Hajime Takei, Kei Minowa, Michael Fuchs, Sudha Biddinger, Jolene J. Windle, Mark A. Subler, Tsuyoshi Murai, Mitsuyoshi Suzuki, Hiroshi Nittono, Arun Sanyal, William M. Pandak   +13 more
doaj   +2 more sources

Natural Products as Potential Resource Library for Control of Major Swine Enteric Viruses. [PDF]

Transbound Emerg Dis
Major swine enteric viruses (SEVs), including porcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), transmissible gastroenteritis virus (TGEV), swine acute diarrhea syndrome coronavirus (SADS‐CoV), and porcine rotavirus (PoRV), cause severe gastrointestinal diseases in pigs, leading to huge economic losses to the swine industry ...
Zhang J, Liu Y, Ren S, Wang Z, Li Y, Peng L, Fang R.   +6 more
europepmc   +2 more sources