Results 71 to 80 of about 240,893 (243)

Oxysterol 25-hydroxycholesterol activation of ferritinophagy inhibits the development of squamous intraepithelial lesion of cervix in HPV-positive patients

Cell Death Discovery
Squamous intraepithelial lesion of cervix (SIL) in human papillomavirus (HPV)-positive patient often undergoes a silent and long-course development, and most of them with high-grade transit to cervical squamous cell carcinoma (CSCC).
Tianming Wang, Min Gong, Yingfei Lu, Chengcheng Zhao, Ling Ling, Jianquan Chen, Rong Ju   +6 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Syntaxin-1a and SNAP-25 expression level is increased in the blood samples of ischemic stroke patients

Scientific Reports, 2022
The interest for the discovery of blood biomarkers for several neurological disorders, including Ischemic Stroke (IS), is growing and their identification in blood samples would be revolutionary allowing a fast and better pathology prediction or outcome ...
Pamela Cappelletti, Melania Filareti, Laura Masuelli, Roberto Bei, Kambiz Hassanzadeh, Massimo Corbo, Marco Feligioni   +6 more
doaj   +1 more source

Optimized sampling conditions for fecal volatile organic compounds analysis by means of field asymmetric ion mobility spectrometry [PDF]

, 2018
Background Fecal volatile organic compounds (VOCs) are increasingly considered as potential non-invasive, diagnostic biomarkers for various gastrointestinal diseases. Knowledge of influence of sampling conditions on VOC outcomes is limited.
Benninga, Marc A., Bomers, Marije K., Bosch, Sofie, Covington, James A., de Boer, Nanne K. H, de Meij, Tim G. J., el Manouni el Hassani, Sofia, Mulder, Chris J. J., Wicaksono, Alfian   +8 more
core   +2 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

25-Hydroxycholesterol restricts human norovirus replication in human intestinal enteroids

Journal of Virology
Norovirus is the leading cause of acute gastroenteritis worldwide. Since the development of human intestinal enteroid (HIE) cell culture systems, significant advancements have been made in exploring and evaluating therapeutic strategies to combat human ...
Verónica Costantini, Wadzanai P. Mboko, Helen Wall, Kimberly Huynh, Anna M. Montmayeur, Geun Woo Park, Ruijie Xu, Jan Vinjé, Preeti Chhabra   +8 more
doaj   +1 more source

Lysosomal cholesterol accumulation sensitizes to acetaminophen hepatotoxicity by impairing mitophagy.

, 2015
The role of lysosomes in acetaminophen (APAP) hepatotoxicity is poorly understood. Here, we investigated the impact of genetic and drug-induced lysosomal cholesterol (LC) accumulation in APAP hepatotoxicity.
Alarcón-Vila, C, Baulies, A, Fernández-Checa, JC, García-Ruiz, C, Kaplowitz, N, Martínez, L, Núñez, S, Ribas, V, Suda, J, Torres, S, Ybanez, MD   +10 more
core   +1 more source

Action and non-action oriented body representations. insight from behavioural and grey matter modifications in individuals with lower limb amputation [PDF]

, 2018
Following current model of body representations, we aimed to systematically investigate the association between brain modifications, in terms of grey matter loss, and body representation deficits, in terms of alterations of the body schema (BS) and of ...
Boccia, Maddalena, Brunelli, Stefano, De Giorgi, Roberto, Di Vita, Antonella, Galati, Gaspare, Guariglia, Cecilia, Nemmi, Federico, Palermo, Liana, Traballesi, Marco   +8 more
core   +1 more source