Results 51 to 60 of about 11,352 (188)

Evidence that the major oxysterols in human circulation originate from distinct pools of cholesterol: a stable isotope study

Journal of Lipid Research, 2001
The major oxysterols in human circulation are 7α-, 27-, and (24S)-hydroxycholesterol. Two unique experiments were performed to elucidate their origin and kinetics. A volunteer was exposed to 18O2-enriched air. A rapid incorporation of 18O in both 7α- and
Steve Meaney, Moustapha Hassan, Augustinas Sakinis, Dieter Lütjohann, Klaus von Bergmann, Åke Wennmalm, Ulf Diczfalusy, Ingemar Björkhem   +7 more
doaj   +1 more source

Serum 27-hydroxycholesterol in patients with primary biliary cirrhosis suggests alteration of cholesterol catabolism to bile acids via the acidic pathway

Journal of Lipid Research, 1998
Reduced cholesterol synthesis has been reported in patients with primary biliary cirrhosis but no data are available on changes in cholesterol catabolism induced by the disease.
M. Del Puppo, M. Galli Kienle, M.L. Petroni, A. Crosignani, M. Podda   +4 more
doaj   +1 more source

Cholesterol 25-hydroxylation activity of CYP3A

Journal of Lipid Research, 2011
To date, many studies have been conducted using 25-hydroxycholesterol, which is a potent regulator of lipid metabolism. However, the origins of this oxysterol have not been entirely elucidated. Cholesterol 25-hydroxylase is one of the enzymes responsible
Akira Honda, Teruo Miyazaki, Tadashi Ikegami, Junichi Iwamoto, Tomomi Maeda, Takeshi Hirayama, Yoshifumi Saito, Tamio Teramoto, Yasushi Matsuzaki   +8 more
doaj   +1 more source

Key regulatory oxysterols in liver: analysis as Δ4-3-ketone derivatives by HPLC and response to physiological perturbations

Journal of Lipid Research, 2001
A number of oxysterols have been implicated in metabolic regulation. Key among these are (24S),25-epoxycholesterol and (24S)-hydroxycholesterol, high affinity ligands for the nuclear transcription factor liver X receptor α; 27-hydroxycholesterol, a bile ...
Zhe Zhang, Dansu Li, Daniel E. Blanchard, Steven R. Lear, Sandra K. Erickson, Thomas A. Spencer   +5 more
doaj   +1 more source

27-Hydroxycholesterol regulates human SLC22A12 gene expression through estrogen receptor action. [PDF]

FASEB J, 2021
Abstract The excretion and reabsorption of uric acid both to and from urine are tightly regulated by uric acid transporters. Metabolic syndrome conditions, such as obesity, hypercholesterolemia, and insulin resistance, are believed to regulate the expression of uric acid transporters and decrease the excretion of ...
Matsubayashi M, Sakaguchi YM, Sahara Y, Nanaura H, Kikuchi S, Asghari A, Bui L, Kobashigawa S, Nakanishi M, Nagata R, Matsui TK, Kashino G, Hasegawa M, Takasawa S, Eriguchi M, Tsuruya K, Nagamori S, Sugie K, Nakagawa T, Takasato M, Umetani M, Mori E.   +21 more
europepmc   +4 more sources

Hypercholesterolemia-induced Aβ accumulation in rabbit brain is associated with alteration in IGF-1 signaling

Neurobiology of Disease, 2008
Hypercholesterolemia increases levels of β-amyloid (Aβ), a peptide that accumulates in Alzheimer's disease brains. Because cholesterol in the blood does not cross the blood brain barrier (BBB), the link between circulating cholesterol and Aβ accumulation
Sunita Sharma, Jaya Prasanthi R.P., Eric Schommer, Gwen Feist, Othman Ghribi   +4 more
doaj   +1 more source

A Japanese prospective multicenter study of urinary oxysterols in biliary atresia

Scientific Reports, 2021
Diagnosis of biliary atresia (BA) can involve uncertainties. In the present prospective multicenter study, we considered whether urinary oxysterols represent a useful marker for diagnosis of BA in Japanese children.
Ken-ichiro Konishi, Tatsuki Mizuochi, Hajime Takei, Ryosuke Yasuda, Hirotaka Sakaguchi, Jun Ishihara, Yugo Takaki, Masahiro Kinoshita, Naoki Hashizume, Suguru Fukahori, Hiromichi Shoji, Go Miyano, Koichiro Yoshimaru, Toshiharu Matsuura, Yukihiro Sanada, Takahisa Tainaka, Hiroo Uchida, Yumiko Kubo, Hiromu Tanaka, Hideyuki Sasaki, Tsuyoshi Murai, Jun Fujishiro, Yushiro Yamashita, Masaki Nio, Hiroshi Nittono, Akihiko Kimura   +25 more
doaj   +1 more source

Levels of 7-oxocholesterol in cerebrospinal fluid are more than one thousand times lower than reported in multiple sclerosis

Journal of Lipid Research, 2005
In a recent publication [Diestel, A., O. Aktas, D. Hackel, I. Häke, S. Meier, C. S. Raine, R. Nitsch, F. Zipp, and O. Ullrich. 2003. Activation of microglial poly (ADP-ribose)-polymerase-1 by cholesterol breakdown products during neuroinflammation: a ...
Valerio Leoni, Dieter Lütjohann, Thomas Masterman   +2 more
doaj   +1 more source

27-Hydroxycholesterol: a potential endogenous regulator of estrogen receptor signaling [PDF]

Trends in Pharmacological Sciences, 2008
The selective estrogen receptor modulators (SERMs) are synthetic pharmaceuticals, the relative agonist and antagonist activities of which are not equivalent in all cells. Their discovery has raised the possibility that endogenous small molecules might exist that have similar properties and could have important physiological roles.
Carolyn D, DuSell, Donald P, McDonnell
openaire   +2 more sources

Neuronal Cholesterol Deficiency Mediated by Astrocytic SREBP2 Downregulation Leads to Postoperative Cognitive Dysfunction Through Impairment of Hippocampal Synaptic Plasticity and Excitatory Synaptic Transmission

Advanced Science, EarlyView.
The results showed that the reduction of plasma 24‐hydroxycholesterol (24‐OHC) was related to the cognitive decline in elderly surgical patients. Neuroinflammation induced by anesthesia and surgery significantly downregulated SREBP2 in hippocampal reactive astrocytes, resulting in reduced cholesterol synthesis.
He Huang, Chenrui Zhou, Chen Chen, Huimei Tang, Wei Dong, Jie Wan, Weiye Kang, Ao Sun, Yiqi Liu, Chunhui Jin, Xiaobin Lyu, Yankun Zhu, Chenghua Zhou, Yuqing Wu   +13 more
wiley   +1 more source