Further Description and First Genetic Characterization of Oswaldofilaria bacillaris (Nematoda: Onchocercidae) Infecting the Pantanal Caiman (Caiman yacare), with Insights into the Phylogeny of Oswaldofilaria. [PDF]
Lacerda GMC +7 more
europepmc +1 more source
Discerning protein pools by selective staining with self‐labeling tags
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Microscopic and Molecular Identification of Sarcocystis Species in Wild Brown Rats (Rattus norvegicus) in Lithuania and Latvia. [PDF]
Šidlauskas G +3 more
europepmc +1 more source
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
The most unusual diplostomoideans from atypical hosts: <i>Pipatrema mirabilis</i> n. sp., n. g. (Digenea: Diplostomidae) from <i>Pipa pipa</i> (Amphibia: Pipidae) in Brazil and a related species from fish in Argentina. [PDF]
Tkach VV +5 more
europepmc +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Microscopic and Molecular Identification of <i>Sarcocystis</i> spp. in Intestines of Canids and Mustelids Associated with Sarcocyst-Forming Species in Rodent Muscles. [PDF]
Ragauskas A +5 more
europepmc +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Recent postglacial population expansions may explain a surprising lack of lineage splitting in Arctic meiobenthic flatworms. [PDF]
Wernström JV +4 more
europepmc +1 more source
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source

