Results 71 to 80 of about 6,021,471 (299)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Towards the quantum S-matrix of the Pohlmeyer reduced version of AdS_5 x S^5 superstring theory

, 2012
We investigate the structure of the quantum S-matrix for perturbative excitations of the Pohlmeyer reduced version of the AdS_5 x S^5 superstring following arXiv:0912.2958.
A.A. Tseytlin, Ahn, Alday, Alekseev, Arutyunov, Arutyunov, Arutyunov, Arutyunov, B. Hoare, Babichenko, Bakas, Bakas, Beisert, Beisert, Beisert, Beisert, Castro Alvaredo, Castro Alvaredo, Castro-Alvaredo, Chen, de Vega, de Vega, Di Vecchia, Dorey, Dorey, Fernandez-Pousa, Fernandez-Pousa, Fring, Gould, Goykhman, Grigoriev, Grigoriev, Hoare, Hoare, Hoare, Hofman, Hollowood, Hollowood, Hollowood, Hollowood, Hollowood, Hollowood, Iwashita, Jevicki, Jevicki, Klose, Kobayashi, Kobayashi, LeClair, Maillet, Metsaev, Metsaev, Mikhailov, Mikhailov, Mikhailov, Miramontes, Miramontes, Miramontes, Miramontes, Ogievetsky, Okamura, Park, Park, Pesando, Pohlmeyer, Rahmfeld, Roiban, Schmidtt, Shankar, Sorokin, Staudacher, Torrielli, Tseytlin, Zamolodchikov   +73 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Coset approach to the N=2 supersymmetric matrix GNLS hierarchies

, 1997
We discuss a large class of coset constructions of the N=2 sl(n|n-1) affine superalgebra. We select admissible subalgebras, i.e. subalgebras that induce linear chiral/antichiral constraints on the coset supercurrents.
Bonora, L., Krivonos, S., Sorin, A.
core   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Hot Deformation and Dynamic Recrystallization Behavior of CoCrNi and (CoCrNi)₉₄Ti₃Al₃ Medium Entropy Alloys

Metals, 2020
The CoCrNi and precipitate-hardened (CoCrNi)94Ti3Al3 medium entropy alloys (MEAs) have attracted much attention, due to their exceptional mechanical properties, whereas the hot deformation characteristics have not been revealed.
Hai-long Yi, Daixiu Wei, Yingchen Wang, Liqiang Wang, Ming-yang Fang, Kang Yang, Hidemi Kato   +6 more
doaj   +1 more source

Born-Infeld Lagrangian using Cayley-Dickson algebras

, 2003
We rewrite the Born-Infeld Lagrangian, which is originally given by the determinant of a $4 \times 4$ matrix composed of the metric tensor $g$ and the field strength tensor $F$, using the determinant of a $(4 \cdot 2^n) \times (4 \cdot 2^n)$ matrix $H_{4
Connes A., Douglas M., S. KUWATA
core   +2 more sources

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

DrosOMA: the Drosophila Orthologous Matrix browser [version 2; peer review: 2 approved]

F1000Research
Background Comparative genomic analyses to delineate gene evolutionary histories inform the understanding of organismal biology by characterising gene and gene family origins, trajectories, and dynamics, as well as enabling the tracing of speciation ...
Robert M. Waterhouse, Christophe Dessimoz, Antonin Thiébaut, Giulia Campli, Natasha Glover, Adrian M. Altenhoff   +5 more
doaj   +1 more source

Completing a 2×2 Block Matrix of Real Quaternions with a Partial Specified Inverse

Journal of Applied Mathematics, 2013
This paper considers a completion problem of a nonsingular 2×2 block matrix over the real quaternion algebra ℍ: Let m1,  m2,  n1,  n2 be nonnegative integers, m1+m2=n1+n2=n>0, and A12∈ℍm1×n2, A21∈ℍm2×n1, A22∈ℍm2×n2, B11∈ℍn1×m1 be given.
Yong Lin, Qing-Wen Wang
doaj   +1 more source