Results 71 to 80 of about 264,992 (304)

In-Cell Protein Structures from 2D NMR Experiments [PDF]

The Journal of Physical Chemistry Letters, 2016
In-cell NMR spectroscopy provides atomic resolution insights into the structural properties of proteins in cells, but it is rarely used to solve entire protein structures de novo. Here, we introduce a paramagnetic lanthanide-tag to simultaneously measure protein pseudocontact shifts (PCSs) and residual dipolar couplings (RDCs) to be used as input for ...
Müntener, Thomas, Häussinger, Daniel, Selenko, Philipp, Theillet, Francois-Xavier   +3 more
openaire   +5 more sources

Oral Dosed Organo‐Silica Nanoparticles Restore Glucose Homeostasis and β‐Cell Function in Diabetes Rats

Advanced Functional Materials, EarlyView.
An oral nanoplatform, MOP@T@D, which can maintain glucose homeostasis and restore islet β cells in diabetic rats is developed. It achieves efficient intestinal absorption and liver‐targeted delivery. The nanoparticle disintegrates only in response to hyperglycemia to release insulin on demand and provides antioxidant protection through selenoprotein ...
Chenxiao Chu, Mingli Wei, Che Bian, Xiaoshuang Bi, Yaxin Deng, Peifu Xiao, Jiansong Zhao, Yuying Wang, Haibing He, Jingxin Gou, Tian Yin, Xing Tang, Li Yang, Hongbo Zhang, Yu Zhang   +14 more
wiley   +1 more source

Endothelial Cells Angiogenesis in Sulfated Glycosaminoglycan (GAG) Hydrogels Enhanced by Bioactive Glass‐Released Ions

Advanced Functional Materials, EarlyView.
A mechanically tunable hydrogel composed of gelatin, chondroitin sulfate and laminin promotes angiogenesis in vitro without the supplement of growth factors. Endothelial cells morphogenesis was further enhanced by medium conditioned with bioactive glass 58S‐released ions (Ca and Si), thus offering a promising strategy to vascularize 3D tissue ...
Marco Piazzoni, Ilaria Borghi, Francesca Cadamuro, Sophia Dalfino, Riccardo Campanile, Sofia Nizzolo, Valeria Cassina, Francesca Tallia, Julian R. Jones, Francesco Mantegazza, Sabrina Bertini, Lorenzo Moroni, Francesco Nicotra, Laura Russo   +13 more
wiley   +1 more source

NMR Determination of 2D Electron Spin Polarization at $\nu=1/2$

, 1999
Using a `standard' NMR spin-echo technique we determined the spin polarization of two-dimensional electrons, confined to GaAs quantum wells, from the hyperfine shift of Ga nuclei in the wells.
A. Abragam, A. E. Dementyev, A. H. MacDonald, B. I. Halperin, C. Berthier, H. L. Stormer, I. V. Kukushkin, J. K. Jain, J. P. Eisenstein, J. P. Eisenstein, K. Park, L. P. Lévy, L. W. Engel, M. Horvatić, M. Shayegan, N. Freytag, N. N. Kuzma, P. Khandelwal, R. G. Clark, R. Tycko, S. E. Barrett, S. E. Barrett, S. Melinte, S. Melinte, T. Chakraborty, V. Bayot, V. Bayot, W. Kang   +27 more
core   +1 more source

Using the Photostationary State of Arylazopyrazoles to Control Phase Transitions of Liquid Crystals

Advanced Functional Materials, EarlyView.
A series of new arylazopyrazole photoswitches is designed as dopants for liquid crystalline materials. Unprecedented, the distribution of photoisomers at the photostationary state upon irradiation with light of specific wavelengths (365, 460, 520 nm) is used to control the liquid crystalline phase transitions under isothermal conditions, including ...
Tobias Thiele, Kristina Hrybenko, Christoph Wölper, Michael Giese   +3 more
wiley   +1 more source

Introducing the CSP Analyzer: A novel Machine Learning-based application for automated analysis of two-dimensional NMR spectra in NMR fragment-based screening

Computational and Structural Biotechnology Journal, 2020
NMR-based screening, especially fragment-based drug discovery is a valuable approach in early-stage drug discovery. Monitoring fragment-binding in protein-detected 2D NMR experiments requires analysis of hundreds of spectra to detect chemical shift ...
R. Fino, R. Byrne, C.A. Softley, M. Sattler, G. Schneider, G.M. Popowicz   +5 more
doaj   +1 more source

The Superfluid Glass Phase of 3He-A

, 2013
It is established theoretically that an ordered state with continuous symmetry is inherently unstable to arbitrarily small amounts of disorder [1, 2].
Collett, C. A., Gannon, W. J., Halperin, W. P., Li, J. I. A., Pollanen, J., Zimmerman, A. M.   +5 more
core   +1 more source

SI‐bioATRP in Mesoporous Silica for Size‐Exclusion Driven Local Polymer Placement

Advanced Functional Materials, EarlyView.
An enzyme‐catalyzed surface‐initiated atom transfer radical polymerization (SI‐bioATRP) of an anionic monomer within mesoporous silica particles, using hemoglobin as a catalyst, allows for controlling the location of the formed polymer via size‐exclusion effects between the nanopores and the biomacromolecules, thereby opening routes to functional ...
Oleksandr Wondra, Eleonora Ornati, Robert Lehn, Joanna J. Mikolei, Hergen Breitzke, Raheleh Pardehkhorram, Gerd Buntkowsky, Nico Bruns, Annette Andrieu‐Brunsen   +8 more
wiley   +1 more source

Solution conformation of peptide PTSP in DMSO-d6 analyzed by 2D NMR(抑前胸腺肽溶液构象的2D NMR初步分析)

Zhejiang Daxue xuebao. Lixue ban, 2005
抑前胸腺肽PTSP是一种重要的新发现的昆虫神经肽，能够在体内和体外条件下抑制促前胸腺素PTTH对蜕皮激素合成的促进作用，实验材料PTSP以固相方法合成.用2D NMR技术来考察PTSP的DMSO-d6溶液，并记录COSY，NOESY和13C HMQC-COSY谱用于构象分析.利用2D COSY和NOESY归属了1H NMR谱的全部共振峰；再利用HMQC-COSY使全部αC和βC共振峰也得到了归属.分析得到肽链的1H和13C的化学位移和质子间的NOE，结果表明PTSP在DMSO ...
CHENXi(陈熙), PANYuan-jiang(潘远江), HUAYue-jin(华跃进)   +2 more
doaj   +1 more source

NMR analysis of Nile Blue (C. I. Basic Blue 12) and Thionine (C. I. 52000) in solution [PDF]

, 2011
The dyes Nile Blue (C. I. Basic Blue 12, NB) and Thionine (C. I. 52000, TH) were examined in both ionic and neutral forms in different solvents using NMR and UV-visible Spectroscopy to firmly establish the structures of the molecules and to assess the ...
Evstigneev, Maxim P., Hazafy, David, Hutchings, Michael G., Mills, Andrew, Parkinson, John A., Salvia, Marie-Virginie   +5 more
core   +1 more source