Results 231 to 240 of about 5,167,436 (292)

Detection of Ring Structure and Its Flexibility in Periplasmic Region of FliL, Bacterial Flagellar Stator-Associate Protein, in Marine Vibrio. [PDF]

Mol Microbiol
Nishikino T, Takekawa N, Burton-Smith R, Tajimi Y, Murata K, Uchihashi T, Kojima S, Imada K, Homma M.   +8 more
europepmc   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Supramolecular Biopolymer Composed of a Doubly (His)₆-Tagged Tandem Z-Domain Conjugated by Zn^2<b>+</b> Ions. [PDF]

ACS Synth Biol
Razi SG, Krichevsky O, Wachtel E, Albeck S, Peleg Y, Patchornik G.   +5 more
europepmc   +1 more source

TH17–Associated Polyamine Metabolism‐Guided Nanozyme Promotes Alveolar Bone Repair in Periodontitis

Advanced Science, EarlyView.
A pronounced TH17‐skewed immune response is identified in experimental periodontitis, and enrichment of the polyamine pathway is observed during TH17 differentiation, suggesting its potential as an immunometabolic target. Inspired by these findings, DFMO@Ui‐Mn is developed as a therapeutic platform combining cascade ROS scavenging with immunometabolic ...
Cheng Zhu, Tiancheng Li, Yu Jin, Yixin Li, Qicheng Liu, Runzhe Fang, Luyao Qu, Xinyue Tang, Ruomei Li, Xiaoyue Zhao, Jin Hao, Bing Fang, Lunguo Xia   +12 more
wiley   +1 more source

A bovine in vitro platform improves species comparability of mitochondrial apoptosis drug-response readouts. [PDF]

Arch Toxicol
Werry F, Schöniger A, Honak A, Fischer J, Richter P, Edlich F.   +5 more
europepmc   +1 more source

Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen, Yangyi Wang, Tingting Li, Changqing Guo, Zhe Xie, Zhixian Zhang, Xinghua Han, Wei Wang, Jian Wang, Xiaopeng Ma, Yuanzeng Min   +10 more
wiley   +1 more source

Conserved and divergent mitochondrial assemblies in kinetoplastid parasites. [PDF]

Mol Cell
Solayman M, Liao YT, Calvo SE, Vacas AF, Papanastasiou M, Rivera KD, Mani DR, Boyle BW, Deng FG, MitoCarta Tree of Life Consortium, Udeshi ND, Mootha VK, Aphasizheva I, Chao LH, Aphasizhev R.   +14 more
europepmc   +1 more source

Cryo-EM reveals ArnA contamination during purification of a ciliary protein complex. [PDF]

Acta Crystallogr D Struct Biol
Jiang X, Kikkawa M.
europepmc   +1 more source

Role of desolvation on biomolecular liquid-liquid phase separation. [PDF]

Elife
Zhang K, Peng Z, Li W, Wang W.
europepmc   +1 more source

Optimization of purification process and thermal stability of lactoferrin from camel milk. [PDF]

Food Chem X
Liu Y, Liu Y, Zhang H, Huanbieke M, Ma L, Ran C, Cheng Y, Yang J, Yue H, Qu Y.   +9 more
europepmc   +1 more source