Results 51 to 60 of about 5,167,436 (292)

Tissue-Specific Microdissection Coupled with ProteinChip® Array Technologies: Applications in Cancer Research

BioTechniques, 2000
Analysis of whole genomes to monitor specific changes in gene activation or changes in gene copy number due to perturbation has recently become possible using DNA chip technologies.
F. von Eggeling, H. Davies, L. Lomas, W. Fiedler, K. Junker, U. Claussen, G. Ernst   +6 more
doaj   +1 more source

Gene Expression and Proteomics Studies Suggest an Involvement of Multiple Pathways Under Day and Day–Night Combined Heat Stresses During Grain Filling in Wheat

Frontiers in Plant Science, 2021
Recent weather fluctuations imposing heat stress at the time of wheat grain filling cause frequent losses in grain yield and quality. Field-based studies for understanding the effect of terminal heat stress on wheat are complicated by the effect of ...
Venkatesh Chunduri, Venkatesh Chunduri, Amandeep Kaur, Shubhpreet Kaur, Aman Kumar, Saloni Sharma, Natasha Sharma, Pargat Singh, Payal Kapoor, Satveer Kaur, Anita Kumari, Joy Roy, Jaspreet Kaur, Monika Garg   +13 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

2D-PAGE of Pcmt1−/− mice brain cytosolic proteins.

, 2013
Pcmt1−/− brain cytosolic proteins were resolved by 2D-PAGE and proteins stained with colloidal Coomassie blue (upper panel). Pcmt1−/− brain cytosolic proteins co-incubated with 5 µg of α-synuclein (middle panel) or 5 µg of β-synuclein (lower panel) prior
Simon Cass (404931), Edward L. Bolt (404933), Declan Wayne (404932), David E. Ray (404934), Vasanthy Vigneswara (291516), Wayne G. Carter (404935)   +5 more
core   +1 more source

Towards identification of novel putative biomarkers for infective endocarditis by serum proteomic analysis

International Journal of Infectious Diseases, 2020
Introduction: Infective endocarditis (IE) has high mortality, partly due to delayed diagnosis. No biomarker can identify IE in patients with fever and clinical picture of infection.
Magnus Giske Snipsøyr, Henrik Wiggers, Maja Ludvigsen, Allan Stensballe, Henrik Vorum, Steen Hvitfeldt Poulsen, Lars Melholt Rasmussen, Eskild Petersen, Bent Honoré   +8 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

A variant in LIN28B is associated with 2D:4D finger-length ratio, a putative retrospective biomarker of prenatal testosterone exposure [PDF]

, 2010
The ratio of the lengths of an individual's second to fourth digit (2D:4D) is commonly used as a noninvasive retrospective biomarker for prenatal androgen exposure.
Medland, Sarah E, Gordon, S., Henders, A., Henders, Anjali K., Montgomery, Grant W., Campbell, Megan J, Wolke, D., Smith, G. D., Zayats,Tetyana, Medland, Sarah E., Montgomery, Grant W, Smith, G., Deloukas, Panos, Montgomery, G., Henders, Anjali K, Smith, George Davey, Campbell, M., Nyholt, D.R., Peltonen, L., Wolke, Dieter, Glaser, B., Gordon, Scott D., Peltonen, Leena, Martin, Nicholas G., Wright, M. J., Evans, David M, Henders, A. K., Evans, D. M., Wright, M., Medland, S., Martin, N., Timpson, Nicholas J., Evans, D., Glaser, Beate, Montgomery, G. W., Ring, Susan M., Zayats, Tetyana, Campbell, M. J., Nyholt, Dale R., Nyholt, D., Nyholt, Dale R, Evans, David M., Gordon,Scott D., Zayats, T., Wright, Margaret J, Ring, Susan M, Deloukas, P., Martin, Nicholas G, Martin, N. G., Timpson, N., Gordon, S. D., Timpson, Nicholas J, Medland, S. E., Wright, Margaret J., Campbell, Megan J., Ring, S. M., Timpson, N. J., Ring, S., Gordon, Scott D   +58 more
core   +2 more sources

The PAXgene(®) tissue system preserves phosphoproteins in human tissue specimens and enables comprehensive protein biomarker research.

PLoS ONE, 2013
Precise quantitation of protein biomarkers in clinical tissue specimens is a prerequisite for accurate and effective diagnosis, prognosis, and personalized medicine.
Sibylle Gündisch, Christina Schott, Claudia Wolff, Kai Tran, Christian Beese, Christian Viertler, Kurt Zatloukal, Karl-Friedrich Becker   +7 more
doaj   +1 more source

On quantum information before the Page time

Journal of High Energy Physics, 2023
While recent progress in the black hole information problem has shown that the entropy of Hawking radiation follows a unitary Page curve, the quantum state of Hawking radiation prior the Page time is still treated as purely thermal, containing no ...
Jonah Kudler-Flam, Yuya Kusuki
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source