Results 81 to 90 of about 123,501 (158)

2H-Azirines in medicinal chemistry

Chemistry of Heterocyclic Compounds, 2021
The review presents an analysis of studies published in the period 1971–2020 devoted to examination of the biological activity of natural and synthetic 2H-azirine derivatives, their use for bioconjugation, as well as search for some new synthetic methods of structural modification of azirines with the aim of improving their biological activity.
Pavel А. Sakharov, Mikhail S. Novikov, Nikolai V. Rostovskii   +2 more
openaire   +1 more source

Metal-Controlled Switchable Regioselective Synthesis of Substituted Imidazoles and Pyrroles via Ring Opening/Cyclocondensation with 2H-Azirines.

Journal of Organic Chemistry, 2023
Catalytic selective annulation of 2H-azirines constitutes a general and modular strategy for the generation of molecular complexity. By using Pd-catalyzed ring opening/heterocyclization associated with direct cleavage of C-N and C-C bonds under ...
Fen Xu, Wen-Jing Zhu, Peiyuan Wang, Jia Feng, Xin-Ru Chen, Xiao Han, Hao Yan   +6 more
semanticscholar   +1 more source

Palladium/Silver Cocatalyzed Divergent Dimerization of 2H-Azirines for Regioselective Synthesis of Tetrasubstituted Pyrroles and Pyrimidines.

Organic Letters, 2023
The unprecedented dimerizations of 2H-azirines have been developed under the catalysis of palladium and silver. Upon changing the reaction conditions, the fully aryl-substituted pyrrole and pyrimidine derivatives were furnished in moderate yields with ...
Yongxing Zhao, Rui Li, Qingzheng Zhao, Jinzhong Yao, Maozhong Miao   +4 more
semanticscholar   +1 more source

Regioselective Transition Metal-Free Catalytic Ring Opening of 2H-Azirines by Phenols and Naphthols; One-Pot Access to Benzo- and Naphthofurans.

Journal of Organic Chemistry, 2023
Benzofuran and naphthofuran derivatives are synthesized from readily available phenols and naphthols. Regioselective ring openings of 2H-azirine followed by in situ aromatization using a catalytic amount of Brønsted acid have established the novelty of ...
Arnab Roy, Subrata Biswas, Surajit Duari, Srabani Maity, A. Mishra, A. R. D. Souza, Asma M. Elsharif, N. Morgon, S. Biswas   +8 more
semanticscholar   +1 more source

Organocatalysts for the Asymmetric Neber reaction: Synthesis of Chiral 2‐(Tetrazol‐5‐yl)‐2H‐Azirines

ChemistrySelect, 2023
‐ Several novel organocatalysts derived from β‐ and γ‐lactam‐fused thiazolidines and L‐phenylalanine‐based thiazolidines were efficiently synthetized.
Cláudia Alves, Terver J. Sase, Cristina Gadelho, D. Murtinho, M. E. S. Serra, Ana L. Cardoso, T. M. Pinho e Melo   +6 more
semanticscholar   +1 more source

One-Pot Synthesis of Multifunctionalized 1-Pyrrolines from 2-Alkyl-2H-azirines and Diazocarbonyl Compounds.

Journal of Organic Chemistry, 2022
A novel strategy for the synthesis of 1-pyrrolines based on formal [4 + 1] annulation of 2-alkyl-2H-azirines with diazocarbonyl compounds has been developed.
I. Filippov, M. Novikov, A. Khlebnikov, N. Rostovskii   +3 more
semanticscholar   +1 more source

Exploiting 2-Halo-2H-Azirine Chemistry

Current Organic Synthesis, 2004
H-Azirines are the smallest unsaturated heterocyclic compounds containing nitrogen. Despite their strain many stable azirines are known. Due to the high reactivity 2H-azirines have been explored extensively for various synthetic purposes. The ring system occurs naturally in the antibiotics azirinomycin, isolated from Streptomyces auras cultures ...
Teresa Pinho e Melo, Antonio Gonsalves
openaire   +1 more source

Metal-Controlled Enantiodivergent Tandem Rearrangement to Synthesize 2H-Azirines.

Angewandte Chemie
A metal-controlled enantiodivergent rearrangement of α-diazo-β-keto oxime ethers has been developed. Switching the metal catalyst from Co(II) to Fe(II) with an identical ligand completely reverses the asymmetric induction.
Zhendong Yang, Maoping Pu, Liang-Fu Yang, Yuqiao Zhou, Hongda Wu, Bosheng Wang, Xiaoming Feng, Xiaohua Liu   +7 more
semanticscholar   +1 more source

Synthesis of Polysubstituted Pyrimidines through Palladium-Catalyzed Isocyanide Insertion to 2H-Azirines.

Journal of Organic Chemistry, 2023
The domino process of the palladium-catalyzed coupling reaction of isocyanides with 2H-azirine provides various tetrasubstituted pyrimidines via one C-C bond and two C-N bond formations with satisfactory yields. The title compounds are obtained with good
Leyla Saeifard, K. Amiri, F. Rominger, T. Müller, S. Balalaie   +4 more
semanticscholar   +1 more source

Silver-Catalyzed [3 + 2] Annulation of 2H-Azirines and CF3-Imidoyl Sulfoxonium Ylides: Access to CF3-Substituted 1H- and 2H-Pyrroles.

Organic Letters
A novel silver-catalyzed [3 + 2] annulation reaction between 2H-azirines and CF3-imidoyl sulfoxonium ylides has been developed, enabling the synthesis of CF3-substituted pyrrole derivatives.
Haipeng Hu, Runfang Zhu, Yiding Wang, Yiyao Li, Shengnan Yang, Yuhong Zhang, Guizhou Yue   +6 more
semanticscholar   +1 more source