Nitroreductase-triggered indazole formation [PDF]
Nature CommunicationsBiocatalysis contributes significantly to the development of more sustainable synthetic pathways by using mild reaction conditions and water as a solvent.
Henrik Terholsen +5 more
doaj +4 more sources
Visible light-promoted transition metal-free direct C3-carbamoylation of 2H-Indazoles [PDF]
Frontiers in Chemistry, 2022 We reported a general transition metal-free transformation to access C3-carbamoylated 2H-indazoles via visible light-induced oxidative decarboxylation coupling, in the presence of oxamic acids as the coupling sources, 4CzIPN as the photocatalyst, and ...
Chunhua Ma +7 more
doaj +2 more sources
Development of a Continuous Photochemical Benzyne-Forming Process [PDF]
SynOpen, 2021 A continuous-flow process is presented that enables the safe generation and derivatization of benzyne under photochemical conditions. This is facilitated by a new high-power LED lamp emitting light at 365 nm.
Cormac Bracken +2 more
doaj +5 more sources
Synthesis of 2-Alkenyl-2H-indazoles from 2-(2-Carbonylmethyl)-2H-indazoles [PDF]
Molecules, 2016 A procedure has been developed for synthesis of 2-alkenyl-2H-indazoles starting from 2-(2-carbonylmethyl)-2H-indazoles, which are prepared by gallium/aluminium- and aluminium-mediated, direct, regioselective alkylation of indazoles with α-bromocarbonyl ...
Mei-Huey Lin +7 more
doaj +2 more sources
Microwave Assisted Expeditious and Green Cu(II)-Clay Catalyzed Domino One-Pot Three Component Synthesis of 2H-indazoles [PDF]
Bulletin of Chemical Reaction Engineering & Catalysis, 2018 A simple and efficient synthesis of 2H-indazoles is achieved from 2-primary amines, bromobenzaldehydes and sodium azide through domino condensation, C–N and N–N bond formations, catalyzed by a heterogeneous Cu(II)-Clay catalyst.
Bashir Ahmad Dar +2 more
doaj +4 more sources
Davis-Beirut reaction: route to thiazolo-, thiazino-, and thiazepino-2H-indazoles. [PDF]
J Org Chem, 2014 Methods for the construction of thiazolo-, thiazino-, and thiazepino-2H-indazoles from o-nitrobenzaldehydes or o-nitrobenzyl bromides and S-trityl-protected 1°-aminothioalkanes are reported.
Farber KM, Haddadin MJ, Kurth MJ.
europepmc +4 more sources
Copper-Catalyzed Hydroamination of 2-Alkynylazobenzenes: Synthesis of 3-Alkenyl-2H-Indazoles. [PDF]
J Org ChemA copper-catalyzed intramolecular synthesis of 3-alkenyl-2H-indazoles from 2-alkynylazobenzenes is described. The reaction proceeds in a single step via C–N bond formation and a subsequent 1,2-hydride shift, affording products in high yields.
Mañas C, Herrero-Bourdieu J, Merino E.
europepmc +3 more sources
Visible Light-Mediated Heterodifunctionalization of Alkynylazobenzenes for 2H-Indazole Synthesis. [PDF]
Org LettWe disclose the heterodifunctionalization of alkynylazobenzenes promoted exclusively by visible light in the absence of any transition metal and/or photocatalyst.
Mañas C, Merino E.
europepmc +3 more sources
SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF 6-CARBETHOXY-5-(3'-BROMOPHENYL)-3-ARYL-2-CYCLOHEXENONES AND 6-ARYL-4-(3'-BROMOPHENYL)-3-OXO-2,3A,4,5-TETRAHYDRO-2H-INDAZOLES [PDF]
Journal of Sciences, Islamic Republic of Iran, 2002 6-Carbethoxy-5-(3'-bromophenyl)-3-aryl-2-cyclohexenones 2a-j were obtained from the1-Aryl-3-(3'-bromophenyl)-2-propene-1-ones 1a-j by Micheal addition of ethyl acetoacetate, followed by internal Claisen condensation.
doaj +2 more sources
4-Aminoquinoline: a comprehensive review of synthetic strategies. [PDF]
Front Chem4-Aminoquinoline is an important scaffold due to its variety of applications in medicinal, synthetic organic, and industrial chemistry. It has gained great relevance for the development of selective and potent leishmanicidal agents targeting parasite ...
Delgado F +3 more
europepmc +3 more sources