Results 101 to 110 of about 18,263,514 (224)

Synthesis and Biological Evaluation of Well‐Defined M6P(n)‐Modified Glycopeptides for Targeted Protein Degradation

Chemistry – A European Journal, Volume 32, Issue 33, 1 September 2026.
A synthetic methodology has been developed to prepare multifunctional M6P and M6Pn ligands of different valency. The glycopeptides were conjugated to cetuximab and then examined to mediate cellular uptake of fluorescently labeled EGFRvIII. Only cetuximab modified by glycopeptides having 3 or 6 M6P or M6Pn residues demonstrated greater uptake.
Patrycja Lenartowicz, Jan‐Willem H. Langenbach, Nataliia Voloshyna, David Aidukas, Arwin J. Brouwer, John A. W. Kruijtzer, Geert‐Jan Boons   +6 more
wiley   +1 more source

REACTIVITY OF N-SUBSTITUTED p-BENZO AND p-NAPHTHOQUINONEIMINE N-OXIDES TOWARD DIPOLAROPHILES [PDF]

Journal of Sciences, Islamic Republic of Iran, 1990
The dipolar cycloaddition reactivity of N-(1-naphthy1)-1,4- benzoquinoneimine N-oxide and N-phenyl-1,4- naphthoquinoneimine Noxide are investigated, The latter gives the expected adducts with common dipolarophiles such as acrylonitryle, methyl ...
doaj  

Crystal structure of 5-(4-tert-butoxyphenyl)-3-(4-n-octyloxyphenyl)-4,5-dihydroisoxazole

Acta Crystallographica Section E: Crystallographic Communications, 2019
The molecule of the title compound, C27H37NO3, was prepared by [3 + 2] 1,3-dipolar cycloaddition of 4-n-octylphenylnitrile oxide and 4-tert-butoxystyrene, the latter compound being a very useful intermediate to the synthesis of liquid-crystalline ...
Eric S. Sales, Adailton J. Bortoluzzi, Aloir A. Merlo   +2 more
doaj   +1 more source

Cyclic Thiosulfinates: Synthesis and Applications in Chemical Biology and Materials Science

ChemBioChem, Volume 27, Issue 16, 27 August 2026.
Cyclic thiosulfinates (CTs) are strained organosulfur heterocyclic compounds with a polarized ─S(═O)─S─ bond that enables selective thiol reactivity. Advances in synthesis afford tunable scaffolds that support efficient proximal thiol cross‐linking and enable applications in chemical biology and materials science. Cyclic thiosulfinates (CTs) constitute
Benjamin Liebson, Jeffrey N. Agar, Roman Manetsch, Prakash T. Parvatkar   +3 more
wiley   +1 more source

Novel valdecoxib derivatives by ruthenium(ii)-promoted 1,3-dipolar cycloaddition of nitrile oxides with alkynes – synthesis and COX-2 inhibition activity

, 2018
By Ru(ii)-promoted 1,3-dipolar cycloaddition of nitrile oxides with alkynes 3,4-diaryl-substituted isoxazoles are formed in one step, showing high inhibition potency for COX-2.
Roscales García, Silvia, Pietzsch, Jens, Kniess, Torsten, Holger Weiss, Daniel, Torsten Kniess, Köckerling, Martin, Martin Köckerling, Bechmann, Nicole, Daniel Holger Weiss, Nicole Bechmann, Silvia Roscales, Jens Pietzsch   +11 more
core   +1 more source

Copper on Calcium Carbonate and Marble Waste as Recyclable Catalysts for Ultrasound‐Assisted One‐Pot Synthesis of 1,4‐Disubstituted 1,2,3‐Triazoles

ChemSusChem, Volume 19, Issue 16, 27 August 2026.
A sustainable CaCO3‐supported copper catalyst, prepared by simple adsorption of Cu(II) onto natural and marble waste‐derived carbonate materials, promotes ultrasound‐assisted CuAAC reaction in water. The work provides straightforward access to 1,4‐disubstituted 1,2,3‐triazoles under mild conditions while combining catalyst recyclability with the ...
Riccardo Serra, Dipak J. Fartade, Pietro Caboni, Cristina Carucci, Andrea Salis, Enrica Tuveri, Antonella Rossi, Andrea Citarella, Andrea Porcheddu   +8 more
wiley   +1 more source

Synthesis of Trifluoromethylated Spiroisoxazolones via a [3+2] Cycloaddition of Nitrile Imines and Unsaturated Isoxazolones

Molecules
A strategy for constructing trifluoromethylated spiroisoxazolones has been developed. This approach relies on the 1,3-dipolar cycloaddition of CF3-substituted nitrile imines, generated in situ from trifluoroacetyl hydrazonoyl bromides and K2CO3, with the
Wei Zhang, Da-Ming Du
doaj   +1 more source

Aspects of the chemistry of some highly crowded aromatic ligands [PDF]

, 1990
A series of ortho-substituted arylchlorophosphoranes has been prepared. The structures of these compounds have been studied by the use of (^31)Cl n.q.r. and solid-state (^31)P n.m.r. . It has been shown that ortho substitution by groups such as CH(_3) or
Straw, T. A.
core  

1,3-dipolar cycloaddition reactions of C-60 with 3-phenyl-phthalazinium-1-olate. A theoretical study

, 2002
1,3-Dipolar cycloaddition products of the reaction between C-60 and 1-phenyl-phthalazinium-1-olate were studied within the framework of AM1(RHF) level. The reactions involving the double bond between two hexagons and a hexagon and a pentagon, as well as ...
Türker, Burhan Lemi
core  

Retro‐Hetero‐Michael Addition Strategies in Organic Synthesis

European Journal of Organic Chemistry, Volume 29, Issue 32, 24 August 2026.
In this review, synthetic approaches to carbo‐ and heterocyclic compounds, including natural products, published in the last 15 years (2011–2025) which have either relied upon or included a retro‐hetero‐Michael addition step at any stage are discussed.
Dina Scarpi, Ernesto G. Occhiato
wiley   +1 more source