Results 141 to 150 of about 54,789 (273)

Comparative analysis of metabolic and functional cardiac alterations in diet‐ and genetically induced mouse models of cardiac dysfunction

The FEBS Journal, EarlyView.
Dietary and genetic stress trigger different routes to heart failure. In mice, a carbohydrate‐free high‐fat diet caused mitochondrial dysfunction and impaired energy production with preserved pumping function, while genetic obesity led to heart enlargement, fibrosis, and reduced function.
Christiane Ott, Patricia Baumgarten, Thorsten Henning, Daniela Weber, Iwona Wallach, Jana Grune, Ulrich Kintscher, Hermann‐Georg Holzhütter, Tilman Grune, Nikolaus Berndt   +9 more
wiley   +1 more source

The Sir David Cuthbertson Medal Lecture 1991:The mechanisms and treatment of weight loss in cancer [PDF]

, 1992
Ball, Beck, Brennan, Burkinshaw, Chlebowski, Conyers, Cooper, Costa, Dinarello, Emery, Fearon, Fearon, Fearon, Fearon, Gear, Heber, Kenneth C. H. Fearon, Lampidis, Langstein, McIntosh, Nakashima, Nixon, Pain, Preston, te Velde, Tisdale, Warburg, Williams   +27 more
core   +1 more source

HIV PrEP use and unmet need among gay, bisexual and other men who have sex with men in London: An analysis of community cross‐sectional surveys in England 2019–2022

HIV Medicine, EarlyView.
Abstract Objectives In England, HIV pre‐exposure prophylaxis (PrEP) was routinely commissioned at sexual health services from 2020. We compared PrEP use and unmet need among gay, bisexual and other men who have sex with men (GBMSM) in London before (2019) and during (2022) routinely commissioned PrEP and the factors associated with its use.
Flavien Coukan, Dana Ogaz, John Saunders, Gary Murphy, Arham Khawar, Iman Scarlett, Hamish Mohammed, Fiona Burns   +7 more
wiley   +1 more source

Genetic Parameter Estimation for Plasma Biomarkers Associated With Energy Reserves During Critical Physiological Stages in Sheep

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT The ability of ruminants to mobilise and restore body reserves (BR) over time, referred to as BR dynamics, is currently considered an interesting biological component to be included in breeding programs targeting enhanced BR resilience. However, genetic studies of proxies for BR levels and BRD remain scarce, particularly in small ruminants ...
Agnes Nyamiel, Andres Legarra, Didier Marcon, Christian Durand, Sébastien Douls, Gaetan Bonnafe, Anne Tesnière, Eliel González‐García, Dominique Hazard   +8 more
wiley   +1 more source

Narcolepsy and rapid eye movement sleep

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Since the first description of narcolepsy at the end of the 19th Century, great progress has been made. The disease is nowadays distinguished as narcolepsy type 1 and type 2. In the 1960s, the discovery of rapid eye movement sleep at sleep onset led to improved understanding of core sleep‐related disease symptoms of the disease (excessive ...
Francesco Biscarini, Lucie Barateau, Fabio Pizza, Giuseppe Plazzi, Yves Dauvilliers   +4 more
wiley   +1 more source

Once‐Nightly Sodium Oxybate Meets American Academy of Sleep Medicine Criteria for Treatment of Narcolepsy

Journal of Sleep Research, EarlyView.
ABSTRACT Data from the REST‐ON trial were not available before the 2021 American Academy of Sleep Medicine (AASM) clinical practice guideline update, which included a literature review through August 2020. This post hoc analysis from REST‐ON assessed participants who achieved clinically significant improvements on individual AASM clinical significance ...
Luis E. Ortiz, Anne Marie Morse, Michael J. Thorpy, Clete A. Kushida, John Harsh, Thomas Roth, Jennifer Gudeman, Yves Dauvilliers   +7 more
wiley   +1 more source

The Double‐Edged Sword of Gestational Insulin Resistance: Navigating Maternal Adaptation and Its Risks for Pregnancy and Offspring Health

Obesity Reviews, EarlyView.
ABSTRACT Although much research focuses on the effects of hyperglycemia during pregnancy on maternal and offspring health, this narrative review specifically centers on the role of insulin resistance (IR) in pregnancy complications and offspring long‐term health.
Runyu Du, Fei Wang, Ling Li, Qiuyue Wang
wiley   +1 more source

De Novo Design and Synthesis of Novel Benzoxazinone Derivatives Targeting Dihydroxyacid Dehydratase

Plant Biotechnology Journal, EarlyView.
ABSTRACT Dihydroxyacid dehydratase (DHAD), a key enzyme in the branched‐chain amino acid (BCAA) synthesis pathway, is a promising herbicide target. Currently, no commercial herbicides target DHAD, and no inhibitors are in development. Structural analysis suggests that coordination with iron–sulfur clusters and hydrophobic interactions with Tyr215 and ...
Bo He, Yanhao Hu, Xu He, Wang Chen, Wei Yan, Xin Zang, Jiahai Zhou, Yonghao Ye   +7 more
wiley   +1 more source

D-3-hydroxybutyrate oxidation in mitochondria by D-3- Hydroxybutyrate dehydrogenase in Tetrahymena pyriformis

, 2009
Tetrahymena pyriformis a ciliated protozoan, is considered a good indicator of water pollution. However its energy supply is poorly understood. This work was focused on the metabolism of hydroxybutyrate through the study of the membrane bound mitochondrial NAD+-dependent D-3-hydroxybutyrate dehydrogenase (EC.
Akil, Omar, El Kebbaj, Zakaria, Latruffe, Norbert, El Kebbaj, M'Hammed Saïd   +3 more
openaire   +1 more source

The role of substrate materials for the survival and growth of coral micro‐fragment sheets

Restoration Ecology, EarlyView.
Biofouling can have a negative impact on the survival and growth of corals in aquaculture. For coral aquaculture to support reef restoration, there needs to be a cost‐effective and efficient method that reduces the reliance on labor for coral maintenance.
Muhammad Azmi Abdul Wahab, Sophie Ferguson, Breiana Whitehead, Jenny Fong, Pirjo Haikola, Andrea Severati, Elsa Antunes   +6 more
wiley   +1 more source