Results 81 to 90 of about 91,641,710 (291)

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Cerium Oxide Nanoparticle Incorporated Electrospun Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Membranes for Diabetic Wound Healing Applications

, 2019
Insufficient cell proliferation, cell migration, and angiogenesis are among the major causes for nonhealing of chronic diabetic wounds. Incorporation of cerium oxide nanoparticles (nCeO2) in wound dressings can be a promising approach to promote ...
Aloy Antony (7023668), Ala-Eddin Al Moustafa (5472368), Neelakandapillai Sandhyarani (4857904), Ruby Varghese (5938514), Raghunath Narayanan Unni (7023671), Robin Augustine (3976964), Anwarul Hasan (1332066), Yogesh B Dalvi (7023665), Noorunnisa Khanam Patan (7023662)   +8 more
core   +1 more source

β‐Hydroxybutyrate reduces neuronal excitability via GIRK channels

Epilepsia, EarlyView.
β‐Hydroxybutyrate decreases neuronal excitability by activating GIRK channels through HCAR2 signaling, providing a cellular mechanism that may contribute to the antiseizure effects of the ketogenic diet. Abstract Objective The ketogenic diet is used to treat drug‐resistant epilepsy, yet the molecular mechanisms coupling metabolic state to seizure ...
Soudabeh Naderi, John Williamson, Jhanvi Patel, Samikksha Kumar, Huayu Sun, Lucy Dang Nguyen, Katarzyna Rękawek, Ifrah Zawar, Jaideep Kapur   +8 more
wiley   +1 more source

Ketogenic diet fails to mitigate seizures and neuroinflammatory responses in a mouse model of virus‐induced epilepsy

Epilepsia, EarlyView.
Abstract Objective The ketogenic diet (KD) is a high‐fat, low‐carbohydrate intervention widely used to treat drug‐resistant epilepsy, thought to reduce seizures through a combination of metabolic, neuronal, and microbiota‐dependent mechanisms. Additionally, recent studies suggest that the anticonvulsant effects of KD require the gut microbiota, with ...
Casey H. Meili, Kaitlyn Allen, Daniel J. Doty, Sofia Del Fiol, Ana Beatriz DePaula‐Silva   +4 more
wiley   +1 more source

The potential protective effect of 3-Hydroxybutyrate against aortic dissection: a mendelian randomization analysis

Nutrition & Metabolism
Background 3-Hydroxybutyrate, also called β-hydroxybutyrate, is a significant constituent of ketone bodies. Previous observational and experimental studies have suggested that ketogenic diet, especially 3-hydroxybutyrate, may have a protective effect ...
Shi Qiu, Zhen Liu, Chun-ting Wang, Xiao-di Sun, Zeng-qiang Liu, Wen Liu   +5 more
doaj   +1 more source

5-fluorouracil-loaded polyhydroxyalkanoate micro- and nano­particles: preparation, characterisation and in vitro evaluation

ADMET and DMPK
Background and purpose: 5‑fluorouracil (5‑FU) is a widely used antimetabolite chemotherapeutic agent. However, it has substantial cytotoxicity and may cause serious adverse effects, including gastrointestinal toxicity, myelosuppression, and, less ...
Sergei Lipaikin, Aleksei Dorokhin, Galina Ryltseva, Ksenia Afanasova, Tatiana Volova, Cathrine Kessler   +5 more
doaj   +1 more source

Designing Novel Interfaces via Surface Functionalization of Short-Chain-Length Polyhydroxyalkanoates

Advances in Polymer Technology, 2019
Polyhydroxyalkanoates (PHA), a microbial plastic has emerged as promising biomaterial owing to the broad range of mechanical properties. However, some studies revealed that PHA is hydrophobic and has no recognition site for cell attachment and this is ...
S. Vigneswari, J. M. Chai, K. Shantini, K. Bhubalan, A. A. Amirul   +4 more
doaj   +1 more source

Crotonic Acid Production by Pyrolysis and Vapor Fractionation of Mixed Microbial Culture-Based Poly(3-hydroxybutyrate-co-3-hydroxyvalerate)

, 2023
Crotonic acid (CA) and trans-2-pentenoic acid (2-PA) can be obtained from renewable resources by pyrolysis of the bio-based poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) copolymer.
Boelo Schuur (1401403), Boelo Schuur, Vahideh Elhami, Mark A. Hempenius (1584538), Mark A. Hempenius, Vahideh Elhami (14328620)   +5 more
core   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Hydrolytical stability of poly(3-hydroxybutyrate)

, 2018
The bachelor thesis deals with the study of hydrolytical stability of poly(3-hydroxybutyrate) in the hydrolysis with excess of water and in the hydrolytic degradation in melt.
Korčušková, Martina
core