Results 101 to 110 of about 3,733 (181)

Redirecting Intermediary Metabolism to Counteract Cyanide Poisoning

The FASEB Journal, Volume 39, Issue 12, 30 June 2025.
Cyanide is coined “the classic metabolic poison”; however, FDA‐approved cyanide chelators do not counteract cyanide's metabolic damage. Here, we review the mechanisms of cyanide toxicity, with a focus on intermediary metabolism. We present the theory that, within the innate plasticity of the metabolome, there may reside metabolic pathways that can ...
Vik S. Bebarta, Anjali K. Nath
wiley   +1 more source

Bridging the Gap in Cancer Research: Sulfur Metabolism of Leukemic Cells with a Focus on L-Cysteine Metabolism and Hydrogen Sulfide-Producing Enzymes

Biomolecules
Leukemias are cancers of the blood-forming system, representing a significant challenge in medical science. The development of leukemia cells involves substantial disturbances within the cellular machinery, offering hope in the search for effective ...
Konrad Kaleta, Klaudia Janik, Leszek Rydz, Maria Wróbel, Halina Jurkowska   +4 more
doaj   +1 more source

Transcriptomics of the Anthopleura Sea Anemone Reveals Unique Adaptive Strategies to Shallow‐Water Hydrothermal Vent

Ecology and Evolution, Volume 15, Issue 4, April 2025.
The nonsymbiotic sea anemone Anthopleura nigrescens thrives in the extreme shallow‐water hydrothermal vents off Kueishan Island, Taiwan, where they represent some of the world's most extreme environments. Transcriptomic analyses revealed that genes involved in H2S homeostasis, stress resistance, and DNA repair are enriched in vent populations ...
Mei‐Fang Lin, Li‐Lian Liu, Chen‐Tung Arthur Chen   +2 more
wiley   +1 more source

Unraveling the role of thiosulfate sulfurtransferase in metabolic diseases [PDF]

, 2020
Thiosulfate sulfurtransferase (TST, EC 2.8.1.1), also known as Rhodanese, is a mitochondrial enzyme which catalyzes the transfer of sulfur in several molecular pathways.
Aguilar Lozano, Sheila P, Al-Dahmani, Zayana M, de Assis Batista, Fernando, Dolga, Amalia M, Groves, Matthew R, Joles, Jaap A, Kruithof, Paul D, Lunev, Sergey, van Goor, Harry   +8 more
core   +2 more sources

Supersulfides: A Promising Therapeutic Approach for Autoinflammatory Diseases

Microbiology and Immunology, Volume 69, Issue 4, Page 191-202, April 2025.
ABSTRACT Supersulfides are molecular species characterized by catenated sulfur moieties, including low‐molecular‐weight and protein‐bound supersulfides. Emerging evidence suggests that these molecules, abundantly present in diverse organisms, play essential roles far beyond their chemical properties, such as functions in energy metabolism, protein ...
Tianli Zhang, Touya Toyomoto, Tomohiro Sawa, Takaaki Akaike, Tetsuro Matsunaga   +4 more
wiley   +1 more source

MsrR is a thiol-based oxidation-sensing regulator of the XRE family that modulates C. glutamicum oxidative stress resistance

Microbial Cell Factories, 2020
Background Corynebacterium glutamicum thrives under oxidative stress caused by the inevitably extreme environment during fermentation as it harbors antioxidative stress genes.
Meiru Si, Can Chen, Jingyi Zhong, Xiaona Li, Yang Liu, Tao Su, Ge Yang   +6 more
doaj   +1 more source

Coenzyme Q deficiency causes impairment of the sulfide oxidation pathway [PDF]

, 2017
Coenzyme Q (CoQ) is an electron acceptor for sulfide‐quinone reductase (SQR), the first enzyme of the hydrogen sulfide oxidation pathway. Here, we show that lack of CoQ in human skin fibroblasts causes impairment of hydrogen sulfide oxidation ...
Barca, Emanuele, Di Meo, Ivano, Gao, Xing-Huang, Kleiner, Giulio, Sanchez-Quintero, Maria J., Schuelke, Markus, Tadesse, Saba, Ziosi, Marcello   +7 more
core   +1 more source

A simple yet effective H2S‐activated fluorogenic probe for precise imaging of hepatitis and arthritis in situ

BMEMat, Volume 3, Issue 1, March 2025.
In this study, an innovative hydrogen sulfide (H2S)‐activated near‐infrared fluorogenic probe (hCy‐DNP) was developed and its H2S‐specific responses were systematically investigated in vivo and in vitro. With efficient H2S recognition capability, hCy‐DNP successfully achieved high‐precision fluorescent targeted sensing in the phased progression of ...
Weier Liang, Yongning Bian, Animesh Samanta, Xueqian Chen, Xiaohe Yu, Yichen Zheng, Xueyun Gao, Dongdong Su   +7 more
wiley   +1 more source

Hydrogen sulfide protects renal grafts against prolonged cold ischemia-reperfusion injury via specific mitochondrial actions [PDF]

, 2016
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record ...
Haig, A, Jiang, J, Lian, D, Liu, W, Lobb, I, Saha, MN, Sener, A, Torregrossa, R, Whiteman, M, Wood, ME   +9 more
core   +1 more source

Protective role of 3-mercaptopyruvate sulfurtransferase (MPST) in the development of metabolic syndrome and vascular inflammation

Pharmacological Research
Metabolic syndrome (MetS) is a cluster of metabolic abnormalities that occur concurrently and increase the risk of cardiovascular disease. 3-mercaptopyruvate sulfurtransferase (MPST) is a cysteine-catabolizing enzyme that yields pyruvate and hydrogen ...
Paraskevas Zampas, Zhen Li, Antonia Katsouda, Aimilia Varela, Stelios Psarras, Constantinos H. Davos, David J. Lefer, Andreas Papapetropoulos   +7 more
doaj   +1 more source