Results 81 to 90 of about 18,308,335 (162)

Bridging the Gap in Cancer Research: Sulfur Metabolism of Leukemic Cells with a Focus on L-Cysteine Metabolism and Hydrogen Sulfide-Producing Enzymes

Biomolecules
Leukemias are cancers of the blood-forming system, representing a significant challenge in medical science. The development of leukemia cells involves substantial disturbances within the cellular machinery, offering hope in the search for effective ...
Konrad Kaleta, Klaudia Janik, Leszek Rydz, Maria Wróbel, Halina Jurkowska   +4 more
doaj   +1 more source

d‐amino acids: new functional insights

The FEBS Journal, Volume 292, Issue 17, Page 4395-4417, September 2025.
This review explores recent advances in understanding d‐amino acids (d‐AAs) and their pivotal roles across organisms, from plants to humans. d‐AAs have been implicated in key physiological processes, including cancer, inflammation, immune regulation, kidney disease, diabetes, and nervous system function.
Loredano Pollegioni, Natasa Kustrimovic, Luciano Piubelli, Elena Rosini, Valentina Rabattoni, Silvia Sacchi   +5 more
wiley   +1 more source

Structure and Kinetic Analysis of H\u3csub\u3e2\u3c/sub\u3eS Production by Human Mercaptopyruvate Sulfurtransferase [PDF]

, 2013
Background: Mercaptopyruvate sulfurtransferase (MST) generates H2S, a signaling molecule. Results: The detailed kinetics and crystal structure of human MST with bound substrate are reported.
Yamada, Kazuhiro, Banerjee, Ruma V., Koutmos, Markos, Yadav, Pramod Kumar, Chiku, Taurai   +4 more
core  

Potential role of the 3-mercaptopyruvate sulfurtransferase (3-MST)-hydrogen sulfide (H2S) pathway in cancer cells.

, 2020
Hydrogen sulfide (H2S), produced by various endogenous enzyme systems, serves various biological regulatory roles in mammalian cells in health and disease.
Augsburger F, Szabo C
core   +2 more sources

Sulfurous Gases As Biological Messengers and Toxins: Comparative Genetics of Their Metabolism in Model Organisms

Journal of Toxicology, 2011
Gasotransmitters are biologically produced gaseous signalling molecules. As gases with potent biological activities, they are toxic as air pollutants, and the sulfurous compounds are used as fumigants.
Neal D. Mathew, David I. Schlipalius, Paul R. Ebert   +2 more
doaj   +1 more source

Hydrogen sulfide and its role in female reproduction

Frontiers in Veterinary Science
Hydrogen sulfide (H2S) is a gaseous signaling molecule produced in the body by three enzymes: cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3-MST).
Aneta Pilsova, Zuzana Pilsova, Barbora Klusackova, Natalie Zelenkova, Eva Chmelikova, Pavla Postlerova, Marketa Sedmikova   +6 more
doaj   +1 more source

3-Mercaptopyruvate sulfurtransferase disruption in dermal fibroblasts facilitates adipogenic trans-differentiation

Experimental Cell Research, 2019
Transitioning from a differentiated state to a higher-order of plasticity, by partial rather than full reactivation of pluripotency genes, might be a better approach in regenerative medicine. Hydrogen sulfide plays a crucial role in the maintenance and differentiation of mesenchymal stem cells (MSC) that have the potential to differentiate to a diverse
Elena A, Ostrakhovitch, Shin, Akakura, Reiko, Sanokawa-Akakura, Siamak, Tabibzadeh   +3 more
openaire   +2 more sources

Novel Aryl-Substituted Pyrimidones as Inhibitors of 3-Mercaptopyruvate Sulfurtransferase with Antiproliferative Efficacy in Colon Cancer

, 2021
The enzyme 3-mercaptopyruvate sulfurtransferase (3-MST) is one of the more recently identified mammalian sources of H2S. A recent study identified several novel 3-MST inhibitors with micromolar potency.
Vasilakaki, S., Szabo, C., Loup, J., Bantzi, M., Augsburger, F., Myrianthopoulos, V., Mikros, E., Bochet, C.G., Berset, Y.   +8 more
core   +1 more source

Role of Cystathionine β-Synthase and 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation, Migration, and Bioenergetics of Murine Breast Cancer Cells. [PDF]

Antioxidants (Basel), 2023
Santos SS, Rodrigues LOCP, Martins V, Petrosino M, Zuhra K, Ascenção K, Anand A, Abdel-Kader RM, Gad MZ, Bourquin C, Szabo C.   +10 more
europepmc   +1 more source

In silico screening, molecular dynamic simulations, and in vitro activity of selected natural compounds as an inhibitor of Leishmania donovani 3-mercaptopyruvate sulfurtransferase. [PDF]

Parasitol Res, 2022
Kant V, Kumar P, Ranjan R, Kumar P, Mandal D, Vijayakumar S.   +5 more
europepmc   +1 more source