Results 71 to 80 of about 18,308,335 (162)

Glioblastoma cell motility depends on enhanced oxidative stress coupled with mobilization of a sulfurtransferase

Cell Death and Disease, 2022
Cell motility is critical for tumor malignancy. Metabolism being an obligatory step in shaping cell behavior, we looked for metabolic weaknesses shared by motile cells across the diverse genetic contexts of patients’ glioblastoma.
Mirca S. Saurty-Seerunghen, Thomas Daubon, Léa Bellenger, Virgile Delaunay, Gloria Castro, Joris Guyon, Ahmed Rezk, Sylvie Fabrega, Ahmed Idbaih, Fabien Almairac, Fanny Burel-Vandenbos, Laurent Turchi, Eric Duplus, Thierry Virolle, Jean-Michel Peyrin, Christophe Antoniewski, Hervé Chneiweiss, Elias A. El-Habr, Marie-Pierre Junier   +18 more
doaj   +1 more source

Dietary methionine depletion and hydrogen sulfide‐producing genes in perivascular adipose tissue of male Wistar rats

Physiological Reports, Volume 13, Issue 24, December 2025.
Abstract Perivascular adipose tissue (PVAT) regulates vascular tone, and high‐fat diets reportedly lead to the loss of its anti‐contractile properties. Methionine restriction recapitulates many caloric restriction metabolic effects and increases liver expression of activating transcription factor 4 (ATF4) and downstream targets with anti‐contractile ...
Adam Corken, Davis Lee, Elizabeth C. Wahl, James D. Sikes, Keshari M. Thakali   +4 more
wiley   +1 more source

Diurnal Fluctuations in Plasma Hydrogen Sulfide of the Mice

Frontiers in Pharmacology, 2017
Circadian rhythms are essential in a myriad of physiological processes to maintain homeostasis, especially the redox homeostasis. However, little is known about whether plasma H2S exhibits the physiological diurnal variation.
Sheng Jin, Bo Tan, Xu Teng, Ruoni Meng, Xin Jiao, Danyang Tian, Lin Xiao, Hongmei Xue, Qi Guo, Xiaocui Duan, Yuming Wu, Yuming Wu, Yuming Wu   +12 more
doaj   +1 more source

Hydrogen sulfide and polysulfides induce GABA/glutamate/d-serine release, facilitate hippocampal LTP, and regulate behavioral hyperactivity

Scientific Reports, 2023
Hydrogen sulfide (H2S) and polysulfides (H2Sn, n ≥ 2) are signaling molecules produced by 3-mercaptopyruvate sulfurtransferase (3MST) that play various physiological roles, including the induction of hippocampal long-term potentiation (LTP), a synaptic ...
Hiroki Furuie, Yuka Kimura, Tatsuhiro Akaishi, Misa Yamada, Yoshiki Miyasaka, Akiyoshi Saitoh, Norihiro Shibuya, Akiko Watanabe, Naoki Kusunose, Tomoji Mashimo, Takeo Yoshikawa, Mitsuhiko Yamada, Kazuho Abe, Hideo Kimura   +13 more
doaj   +1 more source

Cyanide Beyond Toxicity: A Systematic Review of Its Effects on Vascular Function

Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 5, November 2025.
ABSTRACT Cyanide is widely recognized for its potent toxicity, yet evidence shows that concentrations below 1 μM may enhance cytochrome c oxidase activity and have a regulatory function. Recent findings also demonstrate that mammalian cells, including endothelial cells, produce cyanide endogenously, where it can modulate mitochondrial bioenergetics ...
Elif Alan‐Albayrak, Ulf Simonsen
wiley   +1 more source

Mycobacterium tuberculosis CysA2 is a dual sulfurtransferase with activity against thiosulfate and 3-mercaptopyruvate and interacts with mammalian cells

, 2019
Cyanide is a toxic compound that is converted to the non-toxic thiocyanate by a rhodanese enzyme. Rhodaneses belong to the family of transferases (sulfurtransferases), which are largely studied.
A. Balan, Fessel, M. R., C. C. N. Cambui, Moreno, A. C. R., Meza, A. N., Cambui, C. C. N., Balan, A., A. C. R. Moreno, M. R. Fessel, A. N. Meza   +9 more
core   +1 more source

Shear Stress Regulates ABCA1‐Dependent Membrane Cholesterol Content in Endothelial Cells Facilitating H2S‐Dependent Vasodilation

Microcirculation, Volume 32, Issue 7, October 2025.
ABSTRACT Endothelial cells (ECs) express an array of integral membrane proteins, including ion channels and transporters that contribute to blood flow regulation and cell–cell communication. Many of these membrane proteins are regulated by plasma membrane cholesterol content.
Jacob R. Anderson, Nancy L. Kanagy, Laura V. Gonzalez Bosc, Jay S. Naik   +3 more
wiley   +1 more source

Biochemical and genetic characterization of mercaptopyruvate sulfurtransferase and paralogous putative sulfurtransferases of Escherichia coli

, 2001
Sulfurtransferases, including mercaptopyruvate sulfurtransferase and rhodanese, are widely distributed in living organisms. Mercaptopyruvate sulfurtransferase and rhodanese catalyze the transfer of sulfur from mercaptopyruvate and thiosulfate ...
Jutabha, Promjit
core  

Cysteine Signalling in Plant Pathogen Response

Plant, Cell &Environment, Volume 48, Issue 10, Page 7107-7122, October 2025.
ABSTRACT The amino acid cysteine is the precursor for a wide range of sulfur‐containing functional molecules in plants, including enzyme cofactors and defence compounds. Due to its redox active thiol group cysteine is highly reactive. Synthesis and degradation pathways are present in several subcellular compartments to adjust the intracellular cysteine
Jannis Moormann, Björn Heinemann, Cecile Angermann, Anna Koprivova, Ute Armbruster, Stanislav Kopriva, Tatjana M. Hildebrandt   +6 more
wiley   +1 more source

The mercaptopyruvate sulfurtransferase of trichomonas vaginalis links cysteine catabolism to the production of thioredoxin persulfide

, 2009
Trichomonas vaginalis is a protozoan parasite of humans that is able to synthesize cysteine de novo using cysteine synthase but does not produce glutathione. In this study, high pressure liquid chromatography analysis confirmed that cysteine is the major
Coombs, G.H., Georg, I., Westrop, G.D.
core   +4 more sources