Results 41 to 50 of about 17,169,589 (293)
Journal of Pharmacological Sciences, 2021 Huntington's disease (HD) is an inherited neurodegenerative disorder caused by CAG repeat expansion in the huntingtin (HTT) gene. Here, we examined the effects of antioxidants on 3-nitropropionic acid (3-NP; a mitochondrial complex II inhibitor)-induced ...
Noria Okada +4 more
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Neurobiology of Disease, 2022 Mitochondria dysfunction occurs in the aging brain as well as in several neurodegenerative disorders and predisposes neuronal cells to enhanced sensitivity to neurotoxins.
Paula Dietrich +6 more
doaj +1 more source
Frontiers in Pharmacology, 2021 GTP cyclohydrolase I (GTPCH I) is the rate-limiting enzyme for tetrahydrobiopterin (BH4) biosynthesis; the latter is an essential factor for iNOS activation that contributes neuronal loss in Huntington’s disease (HD).
Aya M. Mustafa +3 more
semanticscholar +1 more source
International Journal of Advanced Research, 2022 Huntingtons disease (HD) is an autosomal dominant neurodegenerative disease. Accordingly, 3-nitropropionic acid (3-NP) has been found to effectively produce HD-like symptoms. Amaranthus viridis Linn (HAEAV), popularly known in Chauraiya in Hindi, may act as a neuroprotective agent in vitro andin vivo.
openaire +1 more source
Suppression of Cpn10 increases mitochondrial fission and dysfunction in neuroblastoma cells. [PDF]
PLoS ONE, 2014 To date, several regulatory proteins involved in mitochondrial dynamics have been identified. However, the precise mechanism coordinating these complex processes remains unclear.
So Jung Park +11 more
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Optical waveguide amplifiers based on NaYF_4: Er^3+, Yb^3+ NPs-PMMA covalent-linking nanocomposites
Optical Materials Express, 2015 NaYF4: Er3+, Yb3+ nanoparticles (NPs) were synthesized by using a high temperature thermal decomposition approach. Under a 980 nm laser excitation, intense emission at 1.53 μm from NaYF4: Er3+,Yb3+ NPs was obtained. NaYF4: Er3+, Yb3+ NPs-PMMA covalent-linking nanocomposite was prepared by copolymerization of the oleic acid-modified NaYF4: Er3+, Yb3 ...
Tianjiao Wang +10 more
openaire +1 more source
Delayed Onset and Reduced Cognitive Deficits through Pre-Conditioning with 3-Nitropropionic Acid is Dependent on Sex and CAG Repeat Length in the R6/2 Mouse Model of Huntington's Disease. [PDF]
, 2016 BACKGROUND: Impairments in energy metabolism are implicated in Huntington's disease (HD) pathogenesis. Reduced levels of the mitochondrial enzyme succinate dehydrogenase (SDH), the main element of complex II, are observed post mortem in the brains of HD ...
Morton, A Jennifer +1 more
core
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Pediatric patients with extracranial solid tumors (ST) receiving chemotherapy are at an increased risk for Pneumocystis jirovecii pneumonia (PJP). However, evidence guiding prophylaxis practices in this population is limited. A PJP‐related fatality at our institution highlighted inconsistent prescribing approaches and concerns about
Kriti Kumar +8 more
wiley +1 more source
RSM-BBD Optimization of Fenton-Like Degradation of 4-Nitrophenol Using Magnetite Impregnated Kaolin
Air, Soil and Water Research, 2020 In this work, we have reported a low-cost and environmentally friendly Fe 3 O 4 -modified activated kaolin (AK-Fe 3 O 4 ) composite for efficient Fenton-like degradation of 4-nitrophenol (4-NP) and optimization of the degradation variables. The AK-Fe 3 O
Neway Belachew +2 more
doaj +1 more source
Role of aquaporin-3 in hyperosmolarity-induced apoptosis of rat nucleus pulposus cells in vitro
Di-san junyi daxue xuebao, 2020 Objective To investigate the role of aquaporin-3 (AQP-3) in hyperosmolarity-induced apoptosis of cultured rat nucleus pulposus (NP) cells. Methods Rat NP cells were cultured under different osmotic pressures (330 and 550 mOsm/kg), and the proliferation ...
ZHANG Zetong +3 more
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