Results 61 to 70 of about 17,169,589 (293)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Altered stimulus frequency and intensity dependence of the somatosensory evoked potential in rats after acute application of two mitochondrial toxins [PDF]

, 2009
Mitochondrial toxins are a special group of toxicants with nervous system ef TRACT - fects. The resulting nervous system damage could be detected and followed-up by means of functional biomarkers but these still have to be worked out.
Bankó, S., Papp, András, Takács, Sz.
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Two Species Evolutionary Game Model of User and Moderator Dynamics

, 2012
We construct a two species evolutionary game model of an online society consisting of ordinary users and behavior enforcers (moderators). Among themselves, moderators play a coordination game choosing between being "positive" or "negative" (or harsh ...
Fan, James, Griffin, Christopher, Mercer, Douglas, Squicciarini, Anna   +3 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

High-Performance Ultraviolet Photodetectors Based on Nanoporous GaN with a Ga₂O₃ Single-Crystal Layer

Nanomaterials
The utilization of a nanoporous (NP) GaN fabricated by electrochemical etching has been demonstrated to be effective in the fabrication of a high-performance ultraviolet (UV) photodetector (PD).
Junjie Wen, Yuankang Wang, Biao Zhang, Rongrong Chen, Hongyan Zhu, Xinyu Han, Hongdi Xiao   +6 more
doaj   +1 more source

New calpain inhibitor preserves brain architecture in 3‐nitropropionic acid (3‐NP) model of Huntington disease

The FASEB Journal, 2009
The 3‐nitropropionic acid model Of Huntington's disease produces a variety of biochemical anomalies. One of these, is the activation of the protease calpain. Excess calpain activity is probably responsible for major cell death expressed as striatial degeneration.
Leo Kesner, Lichuan Yang, M. Flint Beal, Alfred Stracher, Getaw Worku Hassen, Abraham Shulman   +5 more
openaire   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Effects of 3-nitrpropionic acid in rats: general toxicity and neurotoxicity [PDF]

, 2005
Three-nitropropionic acid (3-NP) causes biochemical and morphological alterations in human and animal brain. Young adult male Wistar rats received 3-NP ip. on 5 consecutive days and were investigated four weeks later (subacute treatment).
Nagymajtényi, László, Papp, András, Szabó, Andrea   +2 more
core  

Impact of resonance decays on critical point signals in net-proton fluctuations

, 2016
The non-monotonic beam energy dependence of the higher cumulants of net-proton fluctuations is a widely studied signature of the conjectured presence of a critical point in the QCD phase diagram.
A Bazavov, A Bzdak, AM Halasz, B Berdnikov, B Friman, BD Josephson, C Athanasiou, C Downum, C Gale, C Herold, C Nonaka, D Zschiesche, DT Son, F Karsch, G Endrodi, H Fujii, J Berges, J Cleymans, J Fu, J Steinheimer, M Abu-Shady, M Asakawa, M Asakawa, M Asakawa, M Kitazawa, M Nahrgang, M Nahrgang, M Nahrgang, MA Stephanov, MA Stephanov, MA Stephanov, MA Stephanov, Marcus Bluhm, Marlene Nahrgang, O Kaczmarek, P Garg, P Schofield, PC Hohenberg, R Bellwied, R Guida, S Borsanyi, Steffen A. Bass, T Hatsuda, Thomas Schäfer, V Dexheimer, VV Begun, X Luo, Y Aoki   +47 more
core   +3 more sources