Results 91 to 100 of about 422,853 (267)
Some specific differential identities in 3-prime near-rings
Boletim da Sociedade Paranaense de MatemáticaIn this paper, we study 3-prime near-rings with left generalized semiderivations that satisfy specific diferential identities. Consequently, some well-known results from the literature have been generalized. We also show how the constraints placed on the hypothesis of various results are really not redundant.
Abdelkarim Boua, Samir Mouhssine
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
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Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
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Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Ideal maksimal fuzzy near-ring dan ideal prima fuzzy near-ring [PDF]
, 2010 We discuss the fuzzy ideal of near-ring which includes a fuzzy maximal of near-ring and fuzzy prime ideal of near-ring. Futhermore it was studied the relationship between fuzzy maximal ideal of near-rings and fuzzy prime ideals of near ...
ABDURRAHMAN, Saman
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Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Smarandache Idempotents infinite ring Zn and in Group Ring ZnG [PDF]
, 2005 This paper has 4 sections. In section 1, we just give the basic definition of S-idempotents in rings. In section 2, we prove the existence of S-idempotents in the ring Zn where n = 2mp;m 2 N and p is an odd ...
Vasantha, W.B, Chetry, Moon K.
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
An Annihilator Condition on Prime Rings with Derivations [PDF]
, 2015 [[abstract]]Let R be a prime ring with a derivation d and U be its nonzero Lie ideal. If a 2 R, such that a(d(u))mun = 0 for all u 2 U or aun(d(u))m = 0 for all u 2 U and m; n fixed positive integers, then (i) a = 0 or d(U) = 0 if char R 6= 2, (ii) a = 0
Sharma, R. K., Dhara, Basudeb
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