Results 81 to 90 of about 422,853 (267)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Prime near-ring modules and their links with the generalised group near-ring [PDF]
, 2007 In view of the facts that the definition of a ring led to the definition of a near- ring, the definition of a ring module led to the definition of a near-ring module, prime rings resulted in investigations with respect to primeness in near-rings, one is ...
Juglal, Shaanraj
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Projective prime ideals and localisation in pi-rings [PDF]
, 2001 The results here generalise [2, Proposition 4.3] and [9, Theorem 5.11]. We shall prove the following. THEOREM A. Let R be a Noetherian PI-ring. Let P be a non-idempotent prime ideal of R such that PR is projective. Then P is left localisable and RP is
Chatters, A. W. +5 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
RIGHT MULTIPLIERS AND COMMUTATIVITY OF $3$-PRIME NEAR-RINGS [PDF]
International Journal of Apllied Mathematics, 2021 S. Mouhssine, A. Boua
openaire +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Combinatorics of H-primes in quantum matrices [PDF]
, 2006 For q epsilon C transcendental over Q, we give an algorithmic construction of an order-isomorphism between the set of H-primes of O-q (M-n (C)) and the sub-poset S of the (reverse) Bruhat order of the symmetric group S-2n consisting of those permutations
Stéphane Launois, Launois, Stephane
core +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Derivasi pada Near-Ring Prima - On Derivation In Prime Near-Ring [PDF]
, 2018 Suatu himpunan tak-kosong N dengan dua operasi biner ”+” dan ”.” dinamakan Near-Ring jika memenuhi: (N, +) adalah grup, (N, .) adalah semigrup dan (N, +, .) memenuhi distributif kanan.
Habibi, Mochammad Reza
core