Results 101 to 110 of about 422,853 (267)

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

Prime Lie Rings of Derivations of Commutative Rings II [PDF]

open access: yes, 2013
[[abstract]]Let R be a 2-torsionfree commutative ring, and D a Lie subring and an R-submodule of Der(R) such that R is D-prime.
Lee, Pjek-Hwee; Liu, Cheng-Kai
core  

Characterization of 3-prime near-rings via multiplicative derivations

open access: yesAlgebra and Discrete Mathematics
Summary: In this paper, we will prove some theorems concerning the commutativity of 3-prime near-rings which satisfy some differential identities on semigroup ideals and Jordan ideals of a near-ring \(\mathcal{N}\) admitting a multiplicative derivation.
El Amrani, Slimane   +2 more
openaire   +2 more sources

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

open access: yesMolecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant   +7 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Commuting Condition on Derivation in Prime Near Rings [PDF]

open access: yes, 2019
Several results assert that the existence of a suitably-constrained derivation on a prime near-ring forces the near-ring to be a ring. Our aim in this paper is to investigate the commuting conditions on derivations in near ring.
ZEG, MERKIN MANO
core   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

On near-ring ideals with $(\sigma,\tau)$-derivation [PDF]

open access: yes, 2007
summary:Let $N$ be a $3$-prime left near-ring with multiplicative center $Z$, a $(\sigma ,\tau )$-derivation $D$ on $N$ is defined to be an additive endomorphism satisfying the product rule $D(xy)=\tau (x)D(y)+D(x)\sigma (y)$ for all $x,y\in N$, where ...
Aydin, Neşet, Golbaşi, Öznur
core  

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