Results 141 to 150 of about 9,649,671 (339)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Kent, Lia (2012), The Dynamics of Transitional Justice: International Models and Local Realities in East Timor

open access: yesJournal of Current Southeast Asian Affairs, 2014
Book Review of the monograph: Kent, Lia (2012), The Dynamics of Transitional Justice: International Models and Local Realities in East Timor, Abingdon: Routledge (= Series: Transitional Justice), ISBN: 97804 15504362, 252 ...
Deniz Kocak
doaj  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

Political Parties and Popular Representation in Myanmar’s Democratisation Process

open access: yesJournal of Current Southeast Asian Affairs, 2015
The article examines the role of political parties in Myanmar’s democratisation process. We argue that the substance of democratisation depends on popular representation through political parties but question their capacity to provide such ...
Kristian Stokke   +2 more
doaj  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Censoring the Press: A Barometer of Government Tolerance for Anti-regime Dissent under Authoritarian Rule

open access: yesJournal of Politics in Latin America, 2016
This paper proposes that dissident leaders aiming to build mass opposition movements follow the mainstream press to help them gauge government tolerance for anti-government mass actions in repressive authoritarian regimes. Under conditions of censorship,
Elizabeth Ann Stein
doaj  

Homologous expression and purification of human HAX‐1 for structural studies

open access: yesFEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Russia and Myanmar – Friends in Need?

open access: yesJournal of Current Southeast Asian Affairs, 2015
To date, few political scientists have researched the political, economic, and social relationships between Russia and Myanmar. The two countries, which at first glance may seem to have little in common, have intensified their cooperation in recent years.
Ludmila Lutz-Auras
doaj  

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