Results 31 to 40 of about 2,232,606 (299)

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

The Crux Is the Skin: Reflections on Southeast Asian Personhood

open access: yesJournal of Current Southeast Asian Affairs, 2011
This essay is an exercise in the phenomenology of personhood based on some 25 years of field research among Javanese, Thai, and Filipinos. As I still slip up from time to time, I am convinced that it is relevant to both scholarly researchers and others ...
Niels Mulder
doaj  

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

open access: yesMolecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson   +11 more
wiley   +1 more source

Book Review: Haberkorn, Tyrell, Revolution Interrupted: ...

open access: yesJournal of Current Southeast Asian Affairs, 2012
Book Review of the monograph: Haberkorn, Tyrell (2011), Revolution Interrupted: Farmers, Students, Law and Violence in Northern Thailand Madison, Wisconsin: University of Wisconsin Press, ISBN: 978 0 299 28184 7, 256 ...
Fabian Drahmoune
doaj  

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

open access: yesMolecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Low-Level Corruption Tolerance: An “Action-Based” Approach for Peru and Latin America

open access: yesJournal of Politics in Latin America, 2015
Since the beginning of the past decade, the tolerance of corruption by citizens of most Latin American countries has become a concept in its own right within the broader study of corruption. This construct, however, lacks a systematic approach and is yet
Joseph Pozsgai Alvarez
doaj  

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

open access: yesMolecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova   +18 more
wiley   +1 more source

The Role of Religion and Ethnicity in Jakarta’s 2012 Gubernatorial Election

open access: yesJournal of Current Southeast Asian Affairs, 2014
The victory of Joko Widodo (‘Jokowi’) in Jakarta’s 2012 gubernatorial election has been described as a “triumph of democracy” as Joko and his running mate Basuki Tjahaja Purnama (‘Ahok’), a Chinese Christian, successfully won the election ...
Ken Miichi
doaj  

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

open access: yesMolecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma   +9 more
wiley   +1 more source

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