Results 11 to 20 of about 297,139 (334)

A Complementary Mechanism of Bacterial mRNA Translation Inhibition by Tetracyclines

Frontiers in Microbiology, 2021
Tetracycline has positively impacted human health as well as the farming and animal industries. Its extensive usage and versatility led to the spread of resistance mechanisms followed by the development of new variants of the antibiotic.
Victor Barrenechea, Victor Barrenechea, Maryhory Vargas-Reyes, Miguel Quiliano, Pohl Milón   +4 more
doaj   +1 more source

Abstract P-26: Staphylococcus Aureus 30S Ribosomal Subunit in a Complex with the Era GTPase: Sample Preparation for Cryo-EM [PDF]

International Journal of Biomedicine, 2021
Background: An essential in bacteria GTPase Era is a multifunctional protein that is involved in cell cycle regulation and appears to play a significant role in ribosome biogenesis. It is required for the maturation of the 30S ribosomal subunit.
Evelina Klochkova, Aydar Bikmullin, Shamil Validov, Natalia Garaeva, Marat Yusupov, Konstantin Usachev   +5 more
doaj   +1 more source

Cryo-EM study of an archaeal 30S initiation complex gives insights into evolution of translation initiation

Communications Biology, 2020
Archaeal translation initiation occurs within a macromolecular complex containing the small ribosomal subunit (30S) bound to mRNA, initiation factors aIF1, aIF1A and the ternary complex aIF2:GDPNP:Met-tRNAiMet. Here, we determine the cryo-EM structure of
P. Coureux, Christine Lazennec-Schurdevin, S. Bourcier, Y. Mechulam, E. Schmitt   +4 more
semanticscholar   +1 more source

Alternative conformations and motions adopted by 30S ribosomal subunits visualized by cryo-electron microscopy

bioRxiv, 2020
It is only after recent advances in cryo-electron microscopy that is now possible to describe at high resolution structures of large macromolecules that do not crystalize.
D. Jahagirdar, V. Jha, K. Basu, J. Gómez-Blanco, J. Vargas, J. Ortega   +5 more
semanticscholar   +1 more source

 De novo design of pimarane diterpenoid compounds as potential alternatives to sarecycline for acne vulgaris treatment [PDF]

Pharmacia, 2023
Acne vulgaris is a prevalent skin disorder that affects both adolescents and adults and has a major psychological impact. Antibiotic resistance is one issue that current therapies, including antibiotics, must address.
Adeola Tawakalitu Kola-Mustapha
doaj   +3 more sources

Effect of sulfur fertilization on the physical and chemical properties of crambe (Crambe abyssinica Hochst ex R.E. Fries) seeds

Oilseeds and fats, crops and lipids, 2020
Crambe seeds have numerous industrial applications. Crambe seed oil contains mostly monounsaturated fatty acids. Seeds contain crude protein, amino acid, glucosinolates. They are used in human and animal nutrition.
Ropelewska Ewa, Jankowski Krzysztof J.
doaj   +1 more source

Mitochondrial ribosome assembly in Neurospora. Structural analysis of mature and partially assembled ribosomal subunits by equilibrium centrifugation in CsCl gradients [PDF]

, 1982
In Neurospora, one protein associated with the mitochondrial small ribosomal subunit (S-5, Mr 52,000) is synthesized intramitochondrially and is assumed to be encoded by mtDNA.
Lambowitz, Alan M., LaPolla, Robert J.
core   +1 more source

Incidence of Metabolic Syndrome in Young Japanese Adults in a 6-Year Cohort Study: The Uguisudani Preventive Health Large-Scale Cohort Study (UPHLS)

Journal of Epidemiology, 2020
Introduction: To clarify the incidences of metabolic syndrome (MS) and risks in young Japanese adults by gender. Methods: A total of 58,901 adults who had undergone annual health check-ups in 2010 without a diagnosis of MS or missing data were divided ...
Yasuo Haruyama, Ayako Nakagawa, Kumiko Kato, Masayo Motoi, Toshimi Sairenchi, Mitsumasa Umesawa, Ayako Uematsu, Yuichirou Kudou, Gen Kobashi   +8 more
doaj   +1 more source

Feasibility of the 30 s Sit-to-Stand Test in the Telehealth Setting and Its Relationship to Persistent Symptoms in Non-Hospitalized Patients with Long COVID

Diagnostics, 2022
Fatigue, dyspnea and pain are the main limitations of patients with long COVID. The aim of this study was to determine the feasibility of the 30 s sit-to-stand (30s-STS) test in the telehealth setting and its relationship to persistent symptoms in a ...
Rodrigo Núñez-Cortés, Cristina Flor-Rufino, Francisco Miguel Martínez-Arnau, Anna Arnal-Gómez, Claudia Espinoza-Bravo, David Hernández-Guillén, Sara Cortés-Amador   +6 more
doaj   +1 more source

Functionally critical residues in the aminoglycoside resistance-associated methyltransferase RmtC play distinct roles in 30S substrate recognition

Journal of Biological Chemistry, 2019
Methylation of the small ribosome subunit rRNA in the ribosomal decoding center results in exceptionally high-level aminoglycoside resistance in bacteria.
M. Nosrati, D. Dey, A. Mehrani, Sarah E. Strassler, N. Zelinskaya, E. Hoffer, S. Stagg, C. Dunham, G. Conn   +8 more
semanticscholar   +1 more source