Results 21 to 30 of about 298,990 (289)
BMC Pulmonary Medicine, 2021 Purpose Long non-coding RNAs (lncRNAs) play important roles in the development of pneumonia. We aimed to explore the role of the lncRNA KCNQ1OT1 in pneumonia and its underlying mechanisms.
Ping Wang +3 more
doaj +1 more source
Expression of microRNA-370 in human breast cancer compare with normal samples
Advanced Biomedical Research, 2016 Background: Breast cancer is the second leading cause of deaths from cancer in the woman. MicroRNAs (miRNAs) are endogenous noncoding RNAs that are known critical player in carcinogenesis. The role of miR-370 in malignancies remains controversial because
Halimeh Mollainezhad +4 more
doaj +1 more source
Genetics Research, 2022 Background. Colorectal cancer (CRC) is among the most prevalent malignancies globally. Early detection of precancerous lesions through routine colonoscopy has led to a dramatic reduction in CRC-related incidence and mortality among those between the ages
Qing Lv +3 more
doaj +1 more source
Impact of IMO Sulfur Regulations on Air Quality in Busan, Republic of Korea
Atmosphere, 2022 In this study, we investigate the air quality improvement effect in Busan, the largest port city in South Korea, caused by the implementation of International Maritime Organization (IMO) sulfur regulations.
Yumi Kim +3 more
doaj +1 more source
Cardiovascular Therapeutics, 2022 Background. Circular RNA Transformation/Transcription Domain Associated Protein (circTRRAP, hsa_circ_0081241) was abnormally upregulated in acute myocardial infarction (AMI) patients. However, its biological role and functional mechanism in AMI remain to
Yuan Zhang +5 more
doaj +1 more source
Gene Expression of MicroRNA-370 in Some Iraqi Women with Breast Cancer
Ibn Al-Haitham Journal for Pure and Applied Sciences, 2021 Breast cancer becomes a major threat to female health, many reports refer to a high incidence of breast cancer in Iraq; especially, in the last years. The micro RNA-370 molecules have not been reported in Iraqi cancer patients.
Wafaa Sabri Mahood +2 more
doaj +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
FEBS Open Bio, EarlyView.This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili +2 more
wiley +1 more source
lncRNA NEAT1 mediates sepsis progression by regulating Irak2 via sponging miR-370-3p
Biology Open, 2020 Sepsis is a life-threatening condition and often associated with multiple organ failure. Nuclear-enriched abundant transcript 1 (NEAT1), a member of the long non-coding RNAs (lncRNAs), was reported to be involved in the regulation of sepsis progression ...
Ting Xiao +3 more
doaj +1 more source