Results 1 to 10 of about 262,961 (265)

MiR-370 functions as oncogene in melanoma by direct targeting pyruvate dehydrogenase B

Biomedicine & Pharmacotherapy, 2017
Accumulating evidence has shown that miR-370 play an important role in the development and progression of tumor. However, the role of miR-370 in melanoma remains largely unknown. The present study is designed to investigate the function of miR-370 in melanoma and to explore the molecular mechanism underlying its function.The expression level of miR-370
Shufang, Wei, Weiyuan, Ma
openaire   +2 more sources

MiR-370 enhances cell cycle and represses lipid accumulation in porcine adipocytes

Animal Biotechnology, 2019
MicroRNAs (miRNAs) are emerging as an important regulator during adipose development. Previous studies have revealed that miR-370 is related to lipid metabolic homeostasis, however, its roles in lipid accumulation remain to be established. In this study, we demonstrated that ssc-miR-370 was highly conserved across domestic animals, and relatively ...
Yixin Chu, Ying Yao, Xiao Li
openaire   +2 more sources

A Novel Circulating MiRNA-Based Signature for the Diagnosis and Prognosis Prediction of Early-Stage Cervical Cancer

Technology in Cancer Research & Treatment, 2020
Background: MicroRNAs (miRNAs) have been shown to play a key role in regulating the progression of cervical cancer (CC). This study aimed to develop a circulating miRNA-based molecular signature for the diagnosis and prognosis prediction of early-stage ...
Huajuan Qiu MD, Duoxian Liang MD, Limin Liu MD, Qun Xiang MD, Zhijun Yi MD, Yanqin Ji MD   +5 more
doaj   +1 more source

hsa_circ_0003596, as a novel oncogene, regulates the malignant behavior of renal cell carcinoma by modulating glycolysis

European Journal of Medical Research, 2023
Background This research was planned to analyze hsa_circ_0003596 (circCOL5A1) and glycolysis-focused mechanisms in renal cell carcinoma (RCC). Methods circCOL5A1, miR-370-5p, and PRKCSH levels were determined in RCC tissues and selected cell lines by RT ...
QingZhi Xie, FuQiang Qin, LiHui Luo, ShaoQuan Deng, Ke Zeng, YunChou Wu, DunMing Liao, Lin Luo, KangNing Wang   +8 more
doaj   +1 more source

The protective effect of bone marrow-derived mesenchymal stem cells in liver ischemia/reperfusion injury via down-regulation of miR-370 [PDF]

Iranian Journal of Basic Medical Sciences, 2019
Objective(s): Liver transplantation is the most important therapy for end-stage liver disease and ischemia reperfusion (I/R) injury is indeed a risk factor for hepatic failure after grafting. The role of miRNAs in I/R is not completely understood.
Mohamad Ali Zare, Abdolhossein Zare, Negar Azarpira, Sara Pakbaz   +3 more
doaj   +1 more source

Integration of SNP and mRNA arrays with microRNA profiling reveals that MiR-370 is upregulated and targets NF1 in acute myeloid leukemia. [PDF]

PLoS ONE, 2012
BACKGROUND: Deregulated miRNA expression plays a crucial role in carcinogenesis. Recent studies show different mechanisms leading to miRNA deregulation in cancer; however, alterations affecting miRNAs by DNA copy number variations (CNV) remain poorly ...
Laura García-Ortí, Ion Cristóbal, Cristina Cirauqui, Elisabet Guruceaga, Nerea Marcotegui, María J Calasanz, Remedios Castello-Cros, María D Odero   +7 more
doaj   +1 more source

RETRACTED: Knockdown of Long Non-Coding RNA KCNQ1OT1 Restrained Glioma Cells’ Malignancy by Activating miR-370/CCNE2 Axis

Frontiers in Cellular Neuroscience, 2017
Accumulating evidence has highlighted the potential role of long non-coding RNAs (lncRNAs) as biomarkers and therapeutic targets in solid tumors. Here, we elucidated the function and possible molecular mechanisms of lncRNA KCNQ1OT1 in human glioma U87 ...
Wei Gong, Wei Gong, Jian Zheng, Jian Zheng, Xiaobai Liu, Xiaobai Liu, Yunhui Liu, Yunhui Liu, Junqing Guo, Junqing Guo, Yana Gao, Yana Gao, Wei Tao, Wei Tao, Jiajia Chen, Jiajia Chen, Zhiqing Li, Zhiqing Li, Jun Ma, Jun Ma, Yixue Xue, Yixue Xue   +21 more
doaj   +1 more source

Upregulation of MircoRNA-370 induces proliferation in human prostate cancer cells by downregulating the transcription factor FOXO1. [PDF]

PLoS ONE, 2012
Forkhead box protein O1 (FOXO1), a key member of the FOXO family of transcription factors, acts as a tumor suppressor and has been associated with various key cellular functions, including cell growth, differentiation, apoptosis and angiogenesis ...
Ziqing Wu, Huabin Sun, Weixia Zeng, Jincan He, Xiangming Mao   +4 more
doaj   +1 more source

Plasma levels of lipometabolism-related miR-122 and miR-370 are increased in patients with hyperlipidemia and associated with coronary artery disease

Lipids in Health and Disease, 2012
Background Hyperlipidemia plays a crucial role in the development and progression of coronary artery disease (CAD). Recent studies have identified that microRNAs (miRNAs) are important regulators of lipid metabolism, but little is known about the ...
Gao Wei, He Hui-Wei, Wang Ze-Mu, Zhao Huan, Lian Xiao-Qing, Wang Yong-Sheng, Zhu Jun, Yan Jian-Jun, Zhang Ding-Guo, Yang Zhi-Jian, Wang Lian-Sheng   +10 more
doaj   +1 more source

MicroRNA-370 controls the expression of MicroRNA-122 and Cpt1α and affects lipid metabolism[S]

Journal of Lipid Research, 2010
We previously observed that treatment of mice with a dominant negative form of cJun (dn-cJun) increased the expression of genes involved in lipid metabolism and modulated the expression of nine microRNAs (miR).
Dimitrios Iliopoulos, Konstantinos Drosatos, Yaeko Hiyama, Ira J. Goldberg, Vassilis I. Zannis   +4 more
doaj   +1 more source