Results 41 to 50 of about 10,058 (237)

Regulation of SLD5 gene expression by miR-370 during acute growth of cancer cells [PDF]

Scientific Reports, 2016
AbstractSLD5 is a member of the GINS complex, essential for DNA replication in eukaryotes. It has been reported that SLD5 is involved in early embryogenesis in the mouse and cell cycle progression and genome integrity in Drosophila. SLD5 may be involved in malignant tumor progression, but its relevance in human cancer has not been determined.
Keitaro Yamane, Hisamichi Naito, Taku Wakabayashi, Hironori Yoshida, Fumitaka Muramatsu, Tomohiro Iba, Hiroyasu Kidoya, Nobuyuki Takakura   +7 more
openaire   +2 more sources

miR-370-3p Is a Therapeutic Tool in Anti-glioblastoma Therapy but Is Not an Intratumoral or Cell-free Circulating Biomarker

Molecular Therapy: Nucleic Acids, 2018
In the last decade, microRNAs (miRs) have been described as biomarkers and therapeutic agents. Based on this finding, our aim here is to know if (1) miRNA-370-3p can be used as a biomarker associated with a favorable survival and if (2) miRNA-370-3p can ...
Arulraj Nadaradjane, Joséphine Briand, Gwenola Bougras-Cartron, Valentine Disdero, François M. Vallette, Jean-Sébastien Frenel, Pierre-François Cartron   +6 more
doaj   +1 more source

Circ_0035292 knockdown alleviates lipopolysaccharide (LPS)‐induced WI‐38 cell apoptosis and inflammatory injury

Immunity, Inflammation and Disease, 2023
Background Circular RNAs have emerged as important regulators in the pathogenesis of human diseases, including infantile pneumonia (IP). In this study, we aimed to explore the effects of circ_0035292 on lipopolysaccharide (LPS)‐treated Wistsar Institute (
Ying Guo, Zhouzhen Li, Chen Cheng
doaj   +1 more source

Silencing of miR-370 in human cholangiocarcinoma by allelic loss and interleukin-6 induced maternal to paternal epigenotype switch.

PLoS ONE, 2012
Cholangiocarcinoma (CCA) is a highly lethal malignant tumor arising from the biliary tract epithelium. Interleukin-6 (IL-6) is a major mediator of inflammation and contributor to carcinogenesis within the biliary tree.
Fangmei An, Sumitaka Yamanaka, Sarah Allen, Lewis R Roberts, Gregory J Gores, Timothy M Pawlik, Qing Xie, Masaharu Ishida, Esteban Mezey, Anne C Ferguson-Smith, Yuriko Mori, Florin M Selaru   +11 more
doaj   +1 more source

Circ_002117 binds to microRNA-370 and promotes endoplasmic reticulum stress-induced apoptosis in gastric cancer

Cancer Cell International, 2020
Background Mounting evidence implicates circular RNAs (circRNAs) in various biological processes during cancer progression. Gastric cancer is a main cause of cancer-related deaths worldwide.
Nan Zhou, Hui Qiao, Miaomiao Zeng, Lei Yang, Yongning Zhou, Quanlin Guan   +5 more
doaj   +1 more source

Silencing miR-370-3p rescues funny current and sinus node function in heart failure [PDF]

Scientific Reports, 2020
AbstractBradyarrhythmias are an important cause of mortality in heart failure and previous studies indicate a mechanistic role for electrical remodelling of the key pacemaking ion channel HCN4 in this process. Here we show that, in a mouse model of heart failure in which there is sinus bradycardia, there is upregulation of a microRNA (miR-370-3p ...
Joseph Yanni, Alicia D’Souza, Yanwen Wang, Ning Li, Brian J. Hansen, Stanislav O. Zakharkin, Matthew Smith, Christina Hayward, Bryan A. Whitson, Peter J. Mohler, Paul M. L. Janssen, Leo Zeef, Moinuddin Choudhury, Min Zi, Xue Cai, Sunil Jit R. J. Logantha, Shu Nakao, Andrew Atkinson, Maria Petkova, Ursula Doris, Jonathan Ariyaratnam, Elizabeth J. Cartwright, Sam Griffiths-Jones, George Hart, Vadim V. Fedorov, Delvac Oceandy, Halina Dobrzynski, Mark R. Boyett   +27 more
openaire   +7 more sources

Upregulation of miR-370 contributes to the progression of gastric carcinoma via suppression of FOXO1

Biomedicine & Pharmacotherapy, 2013
FOXO1 is downregulated in a number of cancers. However, the underlying mechanisms are poorly understood. In this study, we report that the expression of miR-370 was upregulated in gastric cancer cell lines and gastric cancer tissues. Overexpression of miR-370 in gastric cancer cells promoted the cell proliferation and anchorage-independent growth ...
Conghai, Fan, Sheng, Liu, Yupeng, Zhao, Youqun, Han, Longqiu, Yang, Guorong, Tao, Qing, Li, Lei, Zhang   +7 more
openaire   +2 more sources

MiR-370 functions as oncogene in melanoma by direct targeting pyruvate dehydrogenase B

Biomedicine & Pharmacotherapy, 2017
Accumulating evidence has shown that miR-370 play an important role in the development and progression of tumor. However, the role of miR-370 in melanoma remains largely unknown. The present study is designed to investigate the function of miR-370 in melanoma and to explore the molecular mechanism underlying its function.The expression level of miR-370
Shufang, Wei, Weiyuan, Ma
openaire   +2 more sources

MiR-370 enhances cell cycle and represses lipid accumulation in porcine adipocytes

Animal Biotechnology, 2019
MicroRNAs (miRNAs) are emerging as an important regulator during adipose development. Previous studies have revealed that miR-370 is related to lipid metabolic homeostasis, however, its roles in lipid accumulation remain to be established. In this study, we demonstrated that ssc-miR-370 was highly conserved across domestic animals, and relatively ...
Yixin Chu, Ying Yao, Xiao Li
openaire   +2 more sources

A Novel Circulating MiRNA-Based Signature for the Diagnosis and Prognosis Prediction of Early-Stage Cervical Cancer

Technology in Cancer Research & Treatment, 2020
Background: MicroRNAs (miRNAs) have been shown to play a key role in regulating the progression of cervical cancer (CC). This study aimed to develop a circulating miRNA-based molecular signature for the diagnosis and prognosis prediction of early-stage ...
Huajuan Qiu MD, Duoxian Liang MD, Limin Liu MD, Qun Xiang MD, Zhijun Yi MD, Yanqin Ji MD   +5 more
doaj   +1 more source