Results 51 to 60 of about 11,305 (171)
The role of miR-370 in fibrosis after myocardial infarction
Molecular Medicine Reports, 2017 In the present study, we investigated the expression of miR‑370 in the border area of infarction after myocardial infarction and its role in the process of post‑infarction fibrosis. A myocardial infarction model in Sprague-Dawley rats was established. After two weeks, the mRNA levels of transforming growth factor‑β1 (TGFβ1), TGFβRII, ColIa1, ColIIIa1 ...
Yuan, Hui, Gao, Jie
openaire +3 more sources
Interaction of miRNA-370-3p and the AKT/Foxo1 pathway in trophoblast cells in gestational diabetes mellitus [PDF]
, 2022 Background and aims: Gestational diabetes mellitus (GDM) is one of the most common clinical pregnant diseases with. miRNAs participate in a variety of biological functions as well as the pathogenesis of GDM. Previously, our group found by qPCR miR-370-3p
Ji, Jinlu
core
Journal of Pharmacological Sciences, 2018 It has been reported that PAQR4 (Progestin and AdipoQ Receptor 4) expression is closely associated with progression of many cancers and microRNA (miRNA) processing.
Ye Feng +5 more
doaj +1 more source
Interaction and cross-talk between non-coding RNAs. [PDF]
, 2017 Non-coding RNA (ncRNA) has been shown to regulate diverse cellular processes and functions through controlling gene expression. Long non-coding RNAs (lncRNAs) act as a competing endogenous RNAs (ceRNAs) where microRNAs (miRNAs) and lncRNAs regulate each ...
Dahiya, Rajvir +3 more
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MiR-370 sensitizes chronic myeloid leukemia K562 cells to homoharringtonine by targeting Forkhead box M1 [PDF]
, 2013 Background Homoharringtonine (HHT) is a kind of cephalotaxus alkaloid used in traditional Chinese medicine. Although HHT has been successfully used as a therapeutic agent for leukemia, the drug resistance and toxicity are major concerns ...
ChunYan Chen +9 more
core +2 more sources
The tumor suppressive role of miRNA-370 by targeting FoxM1 in acute myeloid leukemia
Molecular Cancer, 2012 Background Recent evidence has accumulated that MicroRNA (miRNA) dysregulation occurs in the majority of human malignancies including acute myeloid leukemia (AML) and may contribute to onco-/leukemo-genesis.
Zhang Xiaolu +8 more
doaj +1 more source
MiR‑370 promotes apoptosis in colon cancer by directly targeting MDM4
Oncology Letters, 2017 MicroRNA (miR)-370 functions as a tumor suppressor or promoter in several cancers. However, the expression and biological role of miR-370 in colon cancer remains undefined. In the present study, miR-370 expression in both normal and malignant colon tissues was quantified by quantitative polymerase chain reaction.
Shen, Xiaogang +5 more
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Elevating microRNA-122 in blood improves outcomes after temporary middle cerebral artery occlusion in rats. [PDF]
, 2016 Because our recent studies have demonstrated that miR-122 decreased in whole blood of patients and in whole blood of rats following ischemic stroke, we tested whether elevating blood miR-122 would improve stroke outcomes in rats.
Ander, Bradley P +9 more
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Wnt7a and miR-370-3p: new contributors to bladder cancer invasion
Biotarget, 2018 In eukaryotes, microRNAs (miRNAs) are central regulators of gene expression. These small noncoding RNAs are about 19–24 nucleotides long (1). miRNAs can silence gene expression by binding to a complementary sequence in the 3'-UTR of the target gene, which then triggers mRNA degradation.
Danielle, Scheunemann +5 more
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Silencing miR-370-3p rescues funny current and sinus node function in heart failure [PDF]
Scientific Reports, 2020 AbstractBradyarrhythmias are an important cause of mortality in heart failure and previous studies indicate a mechanistic role for electrical remodelling of the key pacemaking ion channel HCN4 in this process. Here we show that, in a mouse model of heart failure in which there is sinus bradycardia, there is upregulation of a microRNA (miR-370-3p ...
Joseph Yanni +27 more
openaire +7 more sources