Results 71 to 80 of about 262,961 (265)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Effects of miR-370 on AML cell proliferation.
, 2012 (A) NF1 expression after transfection with pre-miR-370 and anti-miR-370 in TF-1 cells. (B) Cell growth of TF1 cells after transfection with pre-miR-370, anti-miR-370 or miR-Control.
Remedios Castello-Cros (127012) +7 more
core +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
, 2019 Additional file 4: Figure S3. MiR-370-3p showed a strong effect on the migration, invasion, and EMT process than miR-877-3p in MG63 and U2OS cells. (a) MiR-370-3p and miR-877-3p inhibited MG63 and U2OS cells to migrate and invade through transwells ...
Shengyu Wang (306423) +13 more
core +1 more source
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
Functional analysis showing that miR-370 regulates NF1.
, 2012 (A) miRNAs expression analysis by real-time PCR after transfection with pre-miRs-370, −379, −432 and −494. (B) Western blot showing NF1 after transfection with pre-miR-370.
Remedios Castello-Cros (127012) +7 more
core +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
, 2019 Additional file 7: Figure S6. MiR-370-3p inhibits Wnt/β-catenin signaling. (a-c) Transfection with miR-370-3p mimics significantly downregulated the expression of β-catenin, C-myc and cyclinD1 as revealed by (a) qRT-PCR, (b) western blot analysis and (c)
Shengyu Wang (306423) +13 more
core +1 more source
, 2020 Additional file 1: Figure S1. GO and pathway analysis of the upregulated genes in GSE13139. Dot plot representing biological process with the top 10 most significantly enriched terms (A), cellular component (B), molecular function (C), KEGG pathways (D ...
Jing Yuan (217967) +8 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Collaterals are crucial factors that influence the infarct growth rate (IGR). We aimed to determine whether a comprehensive multimodal collateral score (MCS), incorporating collateral assessment at the arterial, tissue, and venous levels, is associated with functional independence and provides incremental prognostic value over ...
Giorgio Busto +12 more
wiley +1 more source