Results 81 to 90 of about 336,133 (179)
miR-370 regulates ISG15 expression and influences IFN-α sensitivity in hepatocellular carcinoma cells
Cancer Biomarkers, 2018 BACKGROUND: Interferon-α (IFN-α) is an adjuvant to chemotherapy and radiotherapy for hepatocellular carcinoma (HCC), but some HCC patients do not respond to treatment with IFN-α. METHODS: We performed loss-of-function and gain-of-function experiments to examine the role of ISG15 in the IFN-α sensitivity of LH86, HLCZ01, SMMC7721, and Huh7 cell lines ...Zhuo, Liu, Min, Ma, Lei, Yan, Shilin, Chen, Sha, Li, Darong, Yang, Xiaohong, Wang, Hua, Xiao, Hongyu, Deng, Haizhen, Zhu, Chaohui, Zuo, Man, Xia +11 moreopenaire +3 more sourcesIL-6 and promoter methylation modulate expression of miR-370. A. IL-6 reduces miR-370 expression in HuCCT1 cells.
, 2012 X-axis – duration of IL-6 treatment (in hours). Y-axis – Mean and standard deviation of qRT-PCR-measured expression of miR-370 normalized to RNU6B. B. Treatment with the demethylating agent 5Aza-dC upregulates miR-370 expression in HuCCT1 cells.Fangmei An (126976), Masaharu Ishida (126995), Qing Xie (104232), Timothy M. Pawlik (126991), Anne C. Ferguson-Smith (127005), Yuriko Mori (43703), Sarah Allen (126984), Florin M. Selaru (127013), Sumitaka Yamanaka (126980), Gregory J. Gores (126988), Lewis R. Roberts (119660), Esteban Mezey (127000) +11 morecore +1 more sourcemiR-127 protects proximal tubule cells against ischemia/reperfusion : identification of Kinesin family member 3B as miR-127 target [PDF]
, 2012 Ischemia/reperfusion (I/R) is at the basis of renal transplantation and acute kidney injury. Molecular mechanisms underlying proximal tubule response to I/R will allow the identification of new therapeutic targets for both clinical settings.Cuppen, E., Bernhard Brüne, David Sáenz-Morales (139779), Konstantinos Stamatakis (139787), Stamatakis, K., Ramos, Edurne, Elisa Conde, Edurne Ramos (139777), Ramos, E., García Bermejo, María Laura, Blanco-Sanchez, I., Edwin Cuppen, Sáenz-Morales, David, Brune, B., Conde, E., Ignacio Blanco-Sánchez (139784), Bermejo, M.L., Luis del Peso (133134), Edwin Cuppen (9902), Stamatakis Andriani, Konstantinos, Stamatakis, Konstantinos, Peso, Luis del, del Peso, Luis, María Laura García Bermejo (139790), Saenz-Morales, D., Conde, Elisa, Konstantinos Stamatakis, María Laura García Bermejo, Edurne Ramos, Aguado-Fraile, Elia, Aguado-Fraile, E., del Peso, L., Ignacio Blanco-Sánchez, Blanco-Sánchez, Ignacio, Brüne, Bernhard, Bernhard Brüne (131193), Cuppen, Edwin, Elia Aguado-Fraile (139775), Elisa Conde (139781), Elia Aguado-Fraile, Luis del Peso, David Sáenz-Morales, Bermejo María Laura García, Sáenz-Morales David, García-Bermejo, María Laura, Aguado-Fraile Elia, del Peso Luis, Conde Elisa, Blanco-Sánchez Ignacio, Ramos Edurne, Brüne Bernhard, Stamatakis Konstantinos, Cuppen Edwin +52 morecore +2 more sourcesCircMYO10 promotes osteosarcoma progression by regulating miR-370-3p/RUVBL1 axis to enhance the transcriptional activity of β-catenin/LEF1 complex via effects on chromatin remodeling
Molecular Cancer, 2019 Background CircMYO10 is a circular RNA generated by back-splicing of gene MYO10 and is upregulated in osteosarcoma cell lines, but its functional role in osteosarcoma is still unknown.Junxin Chen, Gang Liu, Yizheng Wu, Jianjun Ma, Hongfei Wu, Ziang Xie, Shuai Chen, Yute Yang, Shengyu Wang, Panyang Shen, Yifan Fang, Shunwu Fan, Shuying Shen, Xiangqian Fang +13 moredoaj +1 more sourceCircular RNA circUBE2J2 acts as the sponge of microRNA-370-5P to suppress hepatocellular carcinoma progression
Cell Death and Disease, 2021 Accumulating evidences indicate that circular RNAs (circRNAs), a class of non-coding RNAs, play important roles in tumorigenesis. However, the function of circRNAs in hepatocellular carcinoma is largely unknown.Lu Zhang, Yachong Liu, Haisu Tao, He Zhu, Yonglong Pan, Pengcheng Li, Huifang Liang, Bixiang Zhang, Jia Song +8 moredoaj +1 more sourcemiR-370 and IL-6 are inversely correlated in human CCA. A. miR-370 is downregulated in human CCA vs. normal liver tissues.
, 2012 The figure displays the mean and standard deviation of qRT-PCR-measured expression of miR-370 normalized to RNU6B for human CCA and normal liver tissues. B. IL-6 is upregulated in human CCA vs. normal liver tissues.Fangmei An (126976), Masaharu Ishida (126995), Qing Xie (104232), Timothy M. Pawlik (126991), Anne C. Ferguson-Smith (127005), Yuriko Mori (43703), Sarah Allen (126984), Florin M. Selaru (127013), Sumitaka Yamanaka (126980), Gregory J. Gores (126988), Lewis R. Roberts (119660), Esteban Mezey (127000) +11 morecore +1 more sourcemiR-132/212 knockout mice reveal roles for these miRNAs in regulating cortical synaptic transmission and plasticity [PDF]
, 2013 miR-132 and miR-212 are two closely related miRNAs encoded in the same intron of a small non-coding gene, which have been suggested to play roles in both immune and neuronal function.Mistry, Rajen B., McKenzie, Colin, Palygin, O, Palygin, Oleg, Hutvagner Gyorgy, Remenyi Judit, Mistry Rajen B., Remenyi, J, Yuriy Pankratov, Pankratov Yuriy, Mirjam W M van den Bosch, McKenzie, C, Andrew Macdonald, Frenguelli Bruno G., Hutvagner, G, van den Bosch, Mirjam W. M., Pankratov, Yuriy, van den Bosch, MWM, Mistry, RB, Gyorgy Hutvagner, Judit Remenyi, Arthur J. Simon C., Macdonald, Andrew, Macdonald, A, Colin McKenzie, Frenguelli, BG, Remenyi, Judit, Hutvagner, Gyorgy, Arthur, J. Simon C., Frenguelli, Bruno G., Macdonald Andrew, van den Bosch Mirjam W. M., Rajen B Mistry, Oleg Palygin, Bruno G Frenguelli, Palygin Oleg, Arthur, J. Simon C.; id_orcid, J Simon C Arthur, Arthur, JSC, Pankratov, Y, McKenzie Colin +40 morecore +1 more sourceMiR-370 functions as prognostic marker in patients with hepatocellular carcinoma.
European review for medical and pharmacological sciences, 2018 Large body of evidence has shown that microRNAs (miRNAs) have the potential to serve as prognosis marker. This study is designed to investigate the expression of miR-370 in hepatocellular carcinoma (HCC) patients and to analyze its potential prognostic value.Quantitative real-time quantitative PCR (qPCR) was performed to examine the miR-370 level in ...X-P, Pan, L-H, Huang, X, Wangopenaire +1 more sourceMOESM2 of CircMYO10 promotes osteosarcoma progression by regulating miR-370-3p/RUVBL1 axis to enhance the transcriptional activity of β-catenin/LEF1 complex via effects on chromatin remodeling
, 2019 Additional file 2: Figure S1. The expression of either circMYO10 or miR-370-3p detected by qRT-PCR. (a) Expression of circMYO10 upon transfection with Si-circMYO10.Shengyu Wang (306423), Jianjun Ma (158111), Yute Yang (5463545), Gang Liu (81776), Yizheng Wu (1665766), Panyang Shen (7587599), Junxin Chen (2951379), Xiangqian Fang (6050843), Shuai Chen (506142), Shuying Shen (6050849), Shunwu Fan (4411273), Hongfei Wu (470334), Yifan Fang (7587602), Ziang Xie (3743974) +13 morecore +1 more sourceMOESM3 of CircMYO10 promotes osteosarcoma progression by regulating miR-370-3p/RUVBL1 axis to enhance the transcriptional activity of β-catenin/LEF1 complex via effects on chromatin remodeling
, 2019 Additional file 3: Figure S2. The seed regions between miR-877-3p and circMYO10. (a) Schematic illustration showing complementarity to the miR-370-3p sequence in circMYO10.Shengyu Wang (306423), Jianjun Ma (158111), Yute Yang (5463545), Gang Liu (81776), Yizheng Wu (1665766), Panyang Shen (7587599), Junxin Chen (2951379), Xiangqian Fang (6050843), Shuai Chen (506142), Shuying Shen (6050849), Shunwu Fan (4411273), Hongfei Wu (470334), Yifan Fang (7587602), Ziang Xie (3743974) +13 morecore +1 more source
