Results 101 to 110 of about 10,058 (237)

Effects of miR-1236-3p and miR-370-5p on activation of p21 in various tumors and its inhibition on the growth of lung cancer cells

Tumor Biology, 2017
The mechanism of dsRNA-induced gene activation (RNAa) is being gradually unveiled. The plentiful evidence that it existed in mammalian species other than human demonstrated that dsRNA-mediated RNAa is a conservative phenomenon.
Chuanchang Li, Qiangqiang Ge, Jiaxuan Liu, Qingsong Zhang, Chenghe Wang, Kai Cui, Zhong Chen   +6 more
doaj   +1 more source

MiRNAs Regulating Insulin Sensitivity Are Dysregulated in Polycystic Ovary Syndrome (PCOS) Ovaries and Are Associated With Markers of Inflammation and Insulin Sensitivity

Frontiers in Endocrinology, 2019
Objective: MicroRNAs (miRNAs) are gene expression regulators. Altered miRNA levels are associated with diabetes, insulin resistance, and inflammation. Insulin resistance and inflammation are both features of Polycystic ovary syndrome (PCOS).
Francesca Cirillo, Cecilia Catellani, Pietro Lazzeroni, Chiara Sartori, Alessia Nicoli, Sergio Amarri, Giovanni Battista La Sala, Maria Elisabeth Street   +7 more
doaj   +1 more source

Recent Advances in Ferrite‐Based Materials for Biomedical Applications: A Comprehensive Review

Advanced Materials, EarlyView.
Ferrite nanoplatforms are presented as tunable biomedical materials in which synthesis control, cation engineering, defect/morphology regulation, and surface functionalization govern structure–property–bioactivity relationships. These design strategies enable multifunctional applications including MRI contrast, magnetic hyperthermia, targeted drug ...
Pramod D. Mhase, Varsha C. Pujari, Akash V. Fulari, Sunil M. Patange, Sean Li, Danyang Wang, Sagar E. Shirsath   +6 more
wiley   +1 more source

Physcion induces apoptosis in hepatocellular carcinoma by modulating miR-370.

American journal of cancer research
Hepatocellular carcinoma (HCC) is one of the most common and aggressive malignancies. The current study is designed to explore the role of physcion, a major active ingredient in several traditional herbal medicinal plants, for the treatment of HCC. HCC cell lines, SMMC7721 and HepG2, were treated with physcion and its apoptosis-inducing effect was ...
Xiaoping, Pan, Haixia, Wang, Dongmeng, Tong, Chen, Wang, Li, Sun, Chunjuan, Zhao, Yan, Li, Lida, Zhu, Di, Wu   +8 more
openaire   +1 more source

Stimuli‐Responsive Hierarchical Structuring Controls Survival and Programs Hydrogelation of Supramolecular Metallofibers

Advanced Materials, EarlyView.
Aqueous Zn(II) Salphen metallofibers decorated with PNIPAM undergo reversible, multi‐stimuli‐responsive hierarchical bundling. This higher‐order structuring kinetically stabilizes the otherwise fragile assemblies against dilution, acidic hydrolysis, and transmetallation, enables selective sorting of responsive fibers, and programs hydrogelation at ...
Merlin R. Stühler, László Mérai, Kai Ludwig, Rainer Haag, Quinn A. Besford, Alex J. Plajer   +5 more
wiley   +1 more source

Sustainable Poly(Lactic Acid)/Graphene Oxide Bioelectronic Platform for Neurotransmitters Sensing and Tunable Stimulation of Astrocytes

Advanced Materials, EarlyView.
This work introduces sustainable PLA/graphene oxide bioelectronic interfaces featuring electrodes with tunable conductivity and strong electrocatalytic performance. These platforms were used to implement a new method for tuning astrocyte Ca2+ signaling and for the efficient detection of key biomarkers.
Alessandra Scidà, Giulia Cazzador, Roberta Fabbri, Matteo Calosi, Alessandro Silvestri, Andrea Candini, Fabiola Liscio, Franco Corticelli, Aikaterini Konstantoulaki, Andrea D'Iorio, Marco Caprini, Vincenzo Palermo, Monica Bertoldo, Valentina Benfenati, Chiara Zanardi, Emanuele Treossi   +15 more
wiley   +1 more source

Negotiating in a Foreign Land: Understanding the Curious Interactions Between Intracellular Mitochondria and Internalized Nanoparticles

Advanced Materials Interfaces, EarlyView.
Therapeutic nano‐drug delivery systems interact with cellular mitochondria in a multitude of ways. While the complexity of such interactions disrupts the mitochondrial electron transport chain and increases reactive oxygen species production, thereby contributing to nanoparticle toxicity, they also present unique theranostic opportunities in diseases ...
Sourav Bhattacharjee
wiley   +1 more source

Benchmarking Coaxial and Angular Optical Emission Spectroscopy With Recommendations for Reliable Compositional In Situ Monitoring During Laser Powder Bed Fusion

Advanced Materials Technologies, EarlyView.
ABSTRACT Real‐time insight into local chemistry is critical for reliable part quality in additive manufacturing, especially laser powder bed fusion (PBF‑LB/M), where rapid thermal cycles and localized evaporation can undermine part performance. Optical emission spectroscopy (OES) offers non‑intrusive, in situ plume monitoring, but detection geometry ...
Philipp Gabriel, Bastian Jülich, Anna Rosa Ziefuss, Florian Eibl, Stephan Barcikowski   +4 more
wiley   +1 more source

Dysregulation of TCONS_00006091 contributes to the elevated risk of oral squamous cell carcinoma by upregulating SNAI1, IRS and HMGA2

Scientific Reports
In this study, we aimed to study the role of TCONS_00006091 in the pathogenesis of oral squamous cellular carcinoma (OSCC) transformed from oral lichen planus (OLP).
Danhua Ma, Jijun Chen, Yuyuan Shi, Hongyan Gao, Zhen Wei, Jiayan Fan, Liang Wang   +6 more
doaj   +1 more source

Circular RNA hsa_circ_0003496 Contributes to Tumorigenesis and Chemoresistance in Osteosarcoma Through Targeting (microRNA) miR-370/Krüppel-Like Factor 12 Axis

Cancer Management and Research, 2020
Chaofan Xie,1,* Guanzhao Liang,2,* Yinfeng Xu,1 Erhu Lin3 1Department of Orthopaedics, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong Province, People’s Republic of China; 2Department of Emergency, The First ...
Xie C, Liang G, Xu Y, Lin E
doaj