A mechanically programmable hydrogel for tissue engineering is developed by modulating the molecular threading density of poly(ethylene glycol) diacrylate‐β‐cyclodextrin (PEGDA‐β‐CD) polyrotaxane and combining it with β‐CD‐modified gelatin. The polyrotaxane‐guided transition from disordered pores to laminar microstructures enables precise tuning ...
Shiyi Chen +10 more
wiley +1 more source
Advanced microfluidic and 3D cell culture platforms for modeling vascularization in diabetic foot ulcers: A systematic review of translational challenges and perspectives. [PDF]
da Silva AKA +22 more
europepmc +1 more source
Engineered Nanotopography to Modulate Growth and Signaling of Neuronal Networks
This study examines the interaction between neurons and nanoscale topographies on engineered substrates. Neurons cultured on nanowires, nanopillars and nanoneedles exhibit enhanced neurite outgrowth, form more organized neuronal circuits, and display improved synaptic connectivity, compared to flat substrates.
Hao Nguyen Tran +8 more
wiley +1 more source
Sucrose fuels liver cancer cell growth and spheroid formation: New insights from 2D and 3D cell culture models. [PDF]
Demirel G, Kaya C, Aktas RG.
europepmc +1 more source
Reversible Tuning of Multiple Molecular Kinking for Stem Cell Regulation In Vivo
In this work, we introduce the novel concept of background component‐free “multiple kinks” material platform composed solely of liganded multiple kink‐bearing molecules as a strategy for dynamic biomaterial design. Tri‐kink molecules enable effective near‐infrared light‐triggered ligand masking and visible light‐triggered ligand exposure, thereby ...
Kanghyeon Kim +28 more
wiley +1 more source
Design and evaluation of ionically crosslinked multifunctional ELP-SA composite hydrogels for 3D cell culture. [PDF]
Chen Y +7 more
europepmc +1 more source
Preferential Interfacial Engineering of Hydrogels via Interdigitated Nanoparticle Assembly
Robust surface functionalization of hydrogel surfaces is performed via interdigitated metal nanoparticle assembly, inducing strong affinity with the hydrogel matrix. The partially exposed nanoparticle domains act as interfacial nanobridges that mediate both chemical and physical bonding with diverse materials, including small molecules, fluorous ...
Hyeonjin Kim +11 more
wiley +1 more source
Temporal reassignment and correspondence evaluation with quality control for time-course imaging of 3D cell culture. [PDF]
Cramer EM +10 more
europepmc +1 more source
Lipoprotein‐mimicking nanoparticles (SL‐NPs), comprising Fe3O4@SiO2 cores coated with liposomal bilayers, selectively capture lipoproteins through protein corona formation. The resulting SL‐NP‐lipoprotein complexes can be removed by low‐speed centrifugation, thereby enhancing the purity of small extracellular vesicles (sEVs) isolated from human serum ...
Man‐Di Wang +7 more
wiley +1 more source
Cryopreserving 3D cell culture models of Alzheimer's disease in hydrogel microbeads. [PDF]
Kim JJ +9 more
europepmc +1 more source

