Results 111 to 120 of about 5,851,651 (312)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Cette visualisation en 3D de poumons endommagés par Covid-19 permet de mieux comprendre le danger
, 2020 " Une vidéo en 3D montre les dommages aux poumons d'une personne atteinte du Covid-19. Diffusée par le Dr. Keith Mortman, qui travaille à l'hôpital universitaire de George-Washington, aux Etats-Unis, la vidéo a été produite en partenariat avec Surgical ...
Consortium 3D SHS Team
core
, 2023 L'équipe du Consortium 3D-SHS vous souhaite une excellente année 2023! Janvier 2023 Actualité du CST3D-SHS jc3dshs2022-Mise en ligne des communications Si vous avez manqué les rencontres du consortium 3D qui ont eu lieu les 14-15-16 ...
Consortium 3D SHS Team
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Rubber Impact on 3D Textile Composites [PDF]
, 2011 A low velocity impact study of aircraft tire rubber on 3D textile-reinforced composite plates was performed experimentally and numerically. In contrast to regular unidirectional composite laminates, no delaminations occur in such a 3D textile composite ...
DUPLESSIS KERGOMARD, Yann +9 more
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
A scientific network serving the uses of 3D humanities
, 2020 " The 3D Consortium of the TGIR Huma-Num has been created based on the observation that there are many initiatives around 3D for the Digital Humanities without real coordination between them.
Consortium 3D SHS Team
core
, 2023 Les journées du Consortium 3D SHS ont eu lieu les 14-15-16 décembre dernier à Nantes au sein du laboratoire LS2N. Ces journées ont permis de communiquer sur les avancées au sein du Consortium, et plus généralement, au sein de la communauté scientifique ...
Consortium 3D SHS Team
core
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source