Results 181 to 190 of about 2,629,967 (312)

Single-cell multiomics connects 3D genome and transcriptome alterations in Alzheimer's disease. [PDF]

Science
Zhang Y, Lu X, Kunisky AK, Alam S, Tang J, Zhang R, Wang S, Zhang H, Baroudi J, Ichcho W, Jia D, Ghorbanikalateh S, Ghorbanikalateh S, Wang S, Bennett DA, Mathys H, Duan Z, Ma J.   +17 more
europepmc   +1 more source

Conjugated Porphyrin Polymer With Superior Charge Transfer for Photodynamic‐Immunomodulatory Prevention of CIED Infection in Diabetes

Advanced Healthcare Materials, EarlyView.
Under NIR irradiation, PTCPP generates ROS to eliminate MRSA biofilms and promote M1 macrophage polarization for phagocytosis. After bacterial clearance, the material is phagocytosed by macrophages, shifting their polarization to M2 phenotype via metabolic reprogramming, which synergistically enhances anti‐infection therapy and wound healing.
Honghao Ma, Jinguo Xu, Rongrong Gu, Chuanhui Dong, Te Chen, Yi Mu, Jing Zhu, Yating Wang, Wen Wang, Yingying Zhang, Hongyu Ma, Xiaochen Wang, Sheng Ye, Cheng Cheng   +13 more
wiley   +1 more source

Integrative spatial profiling of 3D genome organization and gene expression in tissue. [PDF]

Cell
Guo P, Cui Y, He J, Waldman AJ, Zhu J, Chen Y, Huang Z, Zhou J, Phillips-Cremins JE, Deng Y.   +9 more
europepmc   +1 more source

Dynamic Loading Regulates Meniscus‐Like Matrix Production in Human Mesenchymal Stromal Cell‐Seeded PET Scaffolds

Advanced Healthcare Materials, EarlyView.
Dynamic compression enhances mesenchymal stromal cell proliferation in nonwoven PET scaffolds under chondrogenic differentiation conditions and triggers mechanosensitive transcriptional programs associated with extracellular matrix remodeling. These findings highlight the potential of mechanically stimulated PET scaffolds as a promising platform for ...
Graciosa Quelhas Teixeira, Luisa de Roy, Anna‐Lotta Feldmeier, Mubashir Ahmad, Sofia Pilão, Maria Ahrens, Anita Ignatius, Carsten Linti, Andreas Martin Seitz   +8 more
wiley   +1 more source

Sequential-GAM constructs the single-cell geometric 3D genome structure. [PDF]

Nucleic Acids Res
Li Y, Wang K, Shi M, Zhang MQ, Gao J.
europepmc   +1 more source

Water‐Activated Phospholipid Phase‐Separation Gel as an Immunomodulatory Anti‐Adhesion Barrier for Postoperative Adhesion Prevention

Advanced Healthcare Materials, EarlyView.
A water‐activated phospholipid phase‐separation gel is repurposed as a drug‐free surgical barrier for postoperative adhesion prevention. Propylene glycol promotes rapid lamellar gel reinforcement, prolonged local retention, and tissue coverage, while phosphatidylcholine‐mediated immunomodulation suppresses inflammatory and fibrotic responses. This dual‐
Jong‐Ju Lee, Yulseung Sung, Yeji Kim, Heesang Yang, Suyeon Pyo, Byeol Yun, Sung‐Joo Hwang   +6 more
wiley   +1 more source

SPRITE maps the 3D genome [PDF]

Nature Methods, 2018
openaire   +2 more sources

3D genome organization in tissue regeneration involves long-range chromatin loops. [PDF]

Sci Adv
Llorens-Giralt P, Camilleri-Robles C, Zuber L, Khadka J, Marti-Marimon M, Crespo-Pera A, Serras F, Gambetta MC, Marti-Renom MA, Corominas M.   +9 more
europepmc   +1 more source

An Engineered Biomimetic Nanoreactor With Cascade Functions for Targeted and Combinatorial Therapy of Ischemic Stroke

Advanced Healthcare Materials, EarlyView.
Preparation of RVG‐modified erythrocyte membrane‐coated HMPB nanocarriers loaded with L‐arginine and NBP (RM@HPAN) and its neuroprotective mechanism. After intravenous injection, RM@HPAN achieves prolonged circulation, RVG‐29‐mediated BBB penetration, and ischemic accumulation.
Shaofa Li, Ying Wu, Huimin Wei, Jinyong Teng, Zaizhi Yang, Jufang Chen, Bao Liao, Xiaoqin Huang, Lanqing Meng, Tong Li   +9 more
wiley   +1 more source

Loss of SUMOylation drives aberrant PRC1 clustering and 3D genome rewiring independent of H3K27me3. [PDF]

Nucleic Acids Res
Akilli N, Puel PS, Stefano MD, Muzzopappa F, Fritsch L, Erdel F, Jost D, Cheutin T, Cavalli G.   +8 more
europepmc   +1 more source