Results 1 to 10 of about 108,471 (109)

3D genome organization [PDF]

Scientific Reports, 2022
Our genomes are highly organized spatially in three-dimensions (3D). In interphase nuclei, the genome is anchored and regulated by various nuclear scaffolds and structures, including the nuclear lamina at the nuclear edge, and nucleoli located more ...
Asli Silahtaroglu, Joanna M. Bridger, Elissa P. Lei   +2 more
doaj   +2 more sources

Erythrocytes 3D genome organization in vertebrates [PDF]

Scientific Reports, 2021
Generation of mature red blood cells, consisting mainly of hemoglobin, is a remarkable example of coordinated action of various signaling networks. Chromatin condensation is an essential step for terminal erythroid differentiation and subsequent nuclear ...
Anastasia Ryzhkova, Alena Taskina, Anna Khabarova, Veniamin Fishman, Nariman Battulin   +4 more
doaj   +2 more sources

3D genome organization in the epithelial-mesenchymal transition spectrum [PDF]

Genome Biology, 2022
Background The plasticity along the epithelial-mesenchymal transition (EMT) spectrum has been shown to be regulated by various epigenetic repertoires. Emerging evidence of local chromatin conformation changes suggests that regulation of EMT may occur at ...
Qing You Pang, Tuan Zea Tan, Vignesh Sundararajan, Yi-Chia Chiu, Edward Yu Wing Chee, Vin Yee Chung, Mahesh A. Choolani, Ruby Yun-Ju Huang   +7 more
doaj   +2 more sources

DNA methylation is required to maintain both DNA replication timing precision and 3D genome organization integrity

Cell Reports, 2021
Summary: DNA replication timing and three-dimensional (3D) genome organization are associated with distinct epigenome patterns across large domains. However, whether alterations in the epigenome, in particular cancer-related DNA hypomethylation, affects ...
Qian Du, Grady C. Smith, Phuc Loi Luu, James M. Ferguson, Nicola J. Armstrong, C. Elizabeth Caldon, Elyssa M. Campbell, Shalima S. Nair, Elena Zotenko, Cathryn M. Gould, Michael Buckley, Kee-Ming Chia, Neil Portman, Elgene Lim, Dominik Kaczorowski, Chia-Ling Chan, Kirston Barton, Ira W. Deveson, Martin A. Smith, Joseph E. Powell, Ksenia Skvortsova, Clare Stirzaker, Joanna Achinger-Kawecka, Susan J. Clark   +23 more
doaj   +3 more sources

Regulating epithelial-mesenchymal plasticity from 3D genome organization [PDF]

Communications Biology
Epithelial-mesenchymal transition (EMT) is a dynamic process enabling polarized epithelial cells to acquire mesenchymal features implicated in development and carcinoma progression.
Qing You Pang, Yi-Chia Chiu, Ruby Yun-Ju Huang   +2 more
doaj   +2 more sources

3D genome organization and epigenetic regulation in autoimmune diseases [PDF]

Frontiers in Immunology, 2023
Three-dimensional (3D) genomics is an emerging field of research that investigates the relationship between gene regulatory function and the spatial structure of chromatin.
Yueqi Qiu, Yueqi Qiu, Delong Feng, Wenjuan Jiang, Wenjuan Jiang, Tingting Zhang, Tingting Zhang, Tingting Zhang, Qianjin Lu, Qianjin Lu, Qianjin Lu, Ming Zhao, Ming Zhao, Ming Zhao   +13 more
doaj   +2 more sources

3D genome organization links non-coding disease-associated variants to genes [PDF]

Frontiers in Cell and Developmental Biology, 2022
Genome sequencing has revealed over 300 million genetic variations in human populations. Over 90% of variants are single nucleotide polymorphisms (SNPs), the remainder include short deletions or insertions, and small numbers of structural variants ...
Gisela Orozco, Gisela Orozco, Stefan Schoenfelder, Stefan Schoenfelder, Nicolas Walker, Stephan Eyre, Stephan Eyre, Peter Fraser, Peter Fraser   +8 more
doaj   +2 more sources

Evolutionary insights into 3D genome organization and epigenetic landscape of Vigna mungo [PDF]

Life Science Alliance
By integrating SMRT long read, Hi-C, and Illumina pair-end sequencing technologies, we report a nearly complete, chromosomal-level assembly of V. mungo and characterize its 3D genome architecture.
Alim Junaid, Baljinder Singh, Sabhyata Bhatia   +2 more
doaj   +2 more sources

Nucleosome wrapping states encode principles of 3D genome organization [PDF]

Nature Communications
Nucleosome is the basic structural unit of the genome. During processes like DNA replication and gene transcription, the conformation of nucleosomes undergoes dynamic changes, including DNA unwrapping and rewrapping, as well as histone disassembly and ...
Zengqi Wen, Ruixin Fang, Ruxin Zhang, Xinqian Yu, Fanli Zhou, Haizhen Long   +5 more
doaj   +2 more sources

Lineage-specific 3D genome organization is assembled at multiple scales by IKAROS [PDF]

Cell, 2023
Daniela Salgado Figueroa, Sourya Bhattacharyya, Mariko Kashiwagi   +2 more
exaly   +2 more sources