Results 31 to 40 of about 4,825,767 (247)
Non-Coding RNA, 2022 This study explored the relationship between 3D genome organization and RNA–DNA triplex-forming sites of long noncoding RNAs (lncRNAs), a group of RNAs that do not code for proteins but are important factors regulating different aspects of genome ...
Benjamin Soibam
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Initial Genomics of the Human Nucleolus [PDF]
, 2010 We report for the first time the genomics of a nuclear compartment of the eukaryotic cell. 454 sequencing and microarray analysis revealed the pattern of nucleolus-associated chromatin domains (NADs) in the linear human genome and identified different ...
Laengst, Gernot +31 more
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Communications Biology, 2021 Kei Fukuda et al. show that the formation of chromatin domains marked by dimethylated H3K9 is functionally linked to the 3D organization of the genome.
Kei Fukuda +7 more
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EPIGENETIC DETERMINANTS OF HETEROCHROMATIC 3D GENOME ORGANIZATION [PDF]
The role of DNA positioning in three-dimensional (3D) space as a regulator of gene expression and genome function is an open area of investigation. Prior studies have reported correlations between chromatin states and 3D genome organization; however, the
Stutzman, Alexis Victoria
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PLoS Genetics, 2020 Membraneless pericentromeric heterochromatin (PCH) domains play vital roles in chromosome dynamics and genome stability. However, our current understanding of 3D genome organization does not include PCH domains because of technical challenges associated ...
Yuh Chwen G Lee +7 more
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Open for connections: HiCAR reveals the interactions of accessible DNA
Cell Genomics, 2022 Hi-C is a powerful technology for exploring 3D genome organization on a genome-wide scale, yet it can be financially and computationally challenging. In a recent issue of Molecular Cell, Wei et al.1 introduce HiCAR, which simplifies Hi-C by targeting the
Benoit Moindrot, Daan Noordermeer
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3D Genome Engineering: Current Advances and Therapeutic Opportunities in Human Diseases
ResearchDynamic chromatin 3-dimensional (3D) conformation is a key mechanism regulating gene expression and cellular function during development and disease.
Xing Jiang +4 more
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Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
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Understanding three-dimensional chromatin organization in diploid genomes
Computational and Structural Biotechnology Journal, 2021 The three-dimensional (3D) organization of chromatin in the nucleus of diploid eukaryotic organisms has fascinated biologists for many years. Despite major progress in chromatin conformation studies, current knowledge regarding the spatial organization ...
Jing Li +3 more
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FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source