Results 1 to 10 of about 10,725 (210)
Persistent homology-based multiscale Hi-C analysis uncovers TADs-mediated gene regulation [PDF]
Scientific ReportsTopologically associating domains (TADs), computationally defined 3D chromatin structures, play pivotal roles in gene expression regulation and genome organization. However, their structural basis and functional implications remain contentious.
Zhen Chiang, Yue Wu
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Pervasive RNA-Binding Protein Enrichment on TAD Boundaries Regulates TAD Organization
Nucleic Acids ResearchAbstract Mammalian genome is hierarchically organized by CTCF and cohesin through loop extrusion mechanism to facilitate the organization of topologically associating domains (TADs). Mounting evidence suggests additional factors/mechanisms exist to orchestrate TAD formation and maintenance.
Huating Wang, Hao Sun, Yulong Qiao
exaly +3 more sources
Cell ReportsSummary: Topologically associated domains (TADs) are interaction subnetworks of chromosomal regions in 3D genomes. TAD boundaries frequently coincide with genome breaks while boundary deletion is under negative selection, suggesting that TADs may ...
Caelinn James +3 more
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A comparative analysis of topological domain callers over RNA-associated interactome [PDF]
BMC BioinformaticsBackground Topological domains (TADs) are consecutive genomic locations with denser local interactions to a certain extent, and they are important for cellular gene expression control and modulation.
Tuna Alaygut, Emre Sefer
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Occurrence of infectious bronchitis in layer birds in Plateau state, north central Nigeria [PDF]
Open Veterinary Journal, 2019 A flock of 54 week-old layer birds exhibiting signs of respiratory distress, greenish diarrhea and drop in egg production was investigated. A marked drop in egg production (55%) was recorded with eggs appearing white and soft-shelled.
Ismaila Shittu +7 more
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TADs or no TADS: Lessons From Single-cell Imaging of Chromosome Architecture [PDF]
Journal of Molecular Biology, 2020 Eukaryotic genomes are folded in a hierarchical organization that reflects and possibly regulates their function. Genomewide studies revealed a new level of organization at the kilobase-to-megabase scale termed "topological associating domains" (TADs).
Gizzi, Andrés M Cardozo +2 more
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Molecular & Cellular Oncology, 2016 Ataxia telangiectasia mutated (ATM) has been known for decades as the main kinase mediating the DNA double-strand break response. Our recent findings suggest that its major role at the sites of breaks likely resides in its ability to modify both the local chromatin landscape and the global chromosome organization in order to promote repair accuracy.
Aymard, Francois, Legube, Gaëlle
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Oral microbiome contributes to the failure of orthodontic temporary anchorage devices (TADs)
BMC Oral Health, 2023 Background The stability of temporary anchorage devices (TADs) is critical in orthodontic clinics. The failure of TADs is multifactorial, and the role of the oral microbiome has not been clearly defined.
Ningrui Zhao +7 more
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MH cortical screws, a revolutionary orthodontic TADs design
Journal of Orthodontic Science, 2022 OBJECTIVE: MH cortical screws were designed to combine the advantages of thick mini-implants with the versatility of micro-screws while avoiding the disadvantages of both.
Mohamed A Elkolaly, Hasan S Hasan
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Scholars Journal of Dental Sciences, 2021 Anchorage is one of the important aspects of orthodontic treatment TAD have gained profound applications in contemporary orthodontic protocol. To treat almost every genre of malocclusion be it arising from dentoalveolar component, skeletal component or combination of both Various skeletal anchorage devices were introduced in the 20th century which ...
Sharath Kumar Shetty +3 more
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