Evolutionary analysis of gene ages across TADs associates chromatin topology with whole-genome duplications [PDF]
Cell ReportsSummary: Topologically associated domains (TADs) are interaction subnetworks of chromosomal regions in 3D genomes. TAD boundaries frequently coincide with genome breaks while boundary deletion is under negative selection, suggesting that TADs may ...
Daniel Rico +2 more
exaly +10 more sources
Oral microbiome contributes to the failure of orthodontic temporary anchorage devices (TADs)
BMC Oral Health, 2023 Background The stability of temporary anchorage devices (TADs) is critical in orthodontic clinics. The failure of TADs is multifactorial, and the role of the oral microbiome has not been clearly defined.
Ningrui Zhao +7 more
doaj +2 more sources
Persistent homology-based multiscale Hi-C analysis uncovers TADs-mediated gene regulation [PDF]
Scientific ReportsTopologically associating domains (TADs), computationally defined 3D chromatin structures, play pivotal roles in gene expression regulation and genome organization. However, their structural basis and functional implications remain contentious.
Zhen Chiang, Yue Wu
doaj +2 more sources
A comparative analysis of topological domain callers over RNA-associated interactome [PDF]
BMC BioinformaticsBackground Topological domains (TADs) are consecutive genomic locations with denser local interactions to a certain extent, and they are important for cellular gene expression control and modulation.
Tuna Alaygut, Emre Sefer
doaj +2 more sources
Occurrence of infectious bronchitis in layer birds in Plateau state, north central Nigeria [PDF]
Open Veterinary Journal, 2019 A flock of 54 week-old layer birds exhibiting signs of respiratory distress, greenish diarrhea and drop in egg production was investigated. A marked drop in egg production (55%) was recorded with eggs appearing white and soft-shelled.
Ismaila Shittu +7 more
doaj +1 more source
MH cortical screws, a revolutionary orthodontic TADs design
Journal of Orthodontic Science, 2022 OBJECTIVE: MH cortical screws were designed to combine the advantages of thick mini-implants with the versatility of micro-screws while avoiding the disadvantages of both.
Mohamed A Elkolaly, Hasan S Hasan
doaj +1 more source
Analysis of oral microbiome on temporary anchorage devices under different periodontal conditions
Progress in Orthodontics, 2023 Background Temporary anchorage devices (TADs) are maximum anchorages that have been widely used in orthodontic treatment. The aim of the study was to uncover whether a history of periodontitis would influence microbiome colonization on the TAD surface ...
Ningrui Zhao +6 more
doaj +1 more source
Making sense of the linear genome, gene function and TADs
Epigenetics & Chromatin, 2022 Background Topologically associating domains (TADs) are thought to act as functional units in the genome. TADs co-localise genes and their regulatory elements as well as forming the unit of genome switching between active and inactive compartments.
Helen S. Long +5 more
doaj +1 more source
BMC Biology, 2018 Background The human genome is highly organized in the three-dimensional nucleus. Chromosomes fold locally into topologically associating domains (TADs) defined by increased intra-domain chromatin contacts.
Jan Krefting +2 more
doaj +1 more source
TADKB: Family classification and a knowledge base of topologically associating domains
BMC Genomics, 2019 Background Topologically associating domains (TADs) are considered the structural and functional units of the genome. However, there is a lack of an integrated resource for TADs in the literature where researchers can obtain family classifications and ...
Tong Liu +7 more
doaj +1 more source