Results 11 to 20 of about 10,207 (224)

A comparative analysis of topological domain callers over RNA-associated interactome [PDF]

open access: yesBMC Bioinformatics
Background Topological domains (TADs) are consecutive genomic locations with denser local interactions to a certain extent, and they are important for cellular gene expression control and modulation.
Tuna Alaygut, Emre Sefer
doaj   +2 more sources

Deciphering chromatin domain, domain community and chromunity for 3D genome maps with Mactop [PDF]

open access: yesCommunications Biology
Advanced high-throughput chromosome conformation capture techniques, like Hi-C, reveal genome organization into structural units like topologically associating domains (TADs), which are crucial in gene expression regulation.
Ran Duan   +4 more
doaj   +2 more sources

Evolutionary stability of topologically associating domains is associated with conserved gene regulation

open access: yesBMC Biology, 2018
Background The human genome is highly organized in the three-dimensional nucleus. Chromosomes fold locally into topologically associating domains (TADs) defined by increased intra-domain chromatin contacts.
Jan Krefting   +2 more
doaj   +1 more source

TADKB: Family classification and a knowledge base of topologically associating domains

open access: yesBMC Genomics, 2019
Background Topologically associating domains (TADs) are considered the structural and functional units of the genome. However, there is a lack of an integrated resource for TADs in the literature where researchers can obtain family classifications and ...
Tong Liu   +7 more
doaj   +1 more source

Are TADs supercoiled? [PDF]

open access: yesNucleic Acids Research, 2018
Topologically associating domains (TADs) are megabase-sized building blocks of interphase chromosomes in higher eukaryotes. TADs are chromosomal regions with increased frequency of internal interactions. On average a pair of loci separated by a given genomic distance contact each other 2-3 times more frequently when they are in the same TAD as compared
Dusan Racko   +3 more
openaire   +4 more sources

TADs in the Dromedary [PDF]

open access: yes, 2019
The transboundary diseases in camel are mainly linked to the regional camel meat market from Sahelian countries (from Mauritania to Somalia) to the Arabian peninsula and North Africa. Indeed, the camel flow in relationship with this market is based on live animals’ export. Because the camel trade can be formal and informal with interconnections between
openaire   +2 more sources

Exploring the 2D and 3D structural properties of topologically associating domains

open access: yesBMC Bioinformatics, 2019
Background Topologically associating domains (TADs) are genomic regions with varying lengths. The interactions within TADs are more frequent than those between different TADs.
Tong Liu, Zheng Wang
doaj   +1 more source

Prospective Study of Oral Health, Pain and Discomfort and Success Rates Following Insertion of Orthodontic Mini-Implants

open access: yesSulaimani Dental Journal, 2018
Objectives: To evaluate oral health and compare the experience of pain and discomfort after the insertion of mini-implants TADs (temporary anchorage device) and to analyze potential factors associated with the stability of TADs used for orthodontic ...
Zana Omer
doaj   +1 more source

An Overview of Transboundary Animal Diseases of Viral Origin in South Asia: What Needs to Be Done?

open access: yesVeterinary Sciences, 2022
Transboundary animal diseases (TADs) pose a serious threat to the sustainability and economic viability of the existing animal agriculture ecosystem in south Asia.
Gyanendra Gongal   +3 more
doaj   +1 more source

CTCF as a boundary factor for cohesin-mediated loop extrusion: evidence for a multi-step mechanism

open access: yesNucleus, 2020
Mammalian genome structure is closely linked to function. At the scale of kilobases to megabases, CTCF and cohesin organize the genome into chromatin loops.
Anders S. Hansen
doaj   +1 more source

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