Results 11 to 20 of about 10,725 (210)
Multi-Layer Transcriptomic Comparison Across Human, Pig, and Mouse Informs Tissue- and Trait-Specific Animal Model Selection. [PDF]
Adv Sci (Weinh)We integrated RNA‐seq data from humans, pigs, and mice across 15 matched tissues based on 14 910 one‐to‐one orthologous genes. Cross‐species similarity was systematically evaluated across multiple regulatory layers, including global co‐expression conservation, co‐expression networks, tissue‐specific programs, and 3D genome architecture.
Dou J +21 more
europepmc +2 more sources
Overcoming Artificial Structures in Resolution-Enhanced Hi-C Data by Signal Decomposition and Multi-Scale Attention. [PDF]
Adv Sci (Weinh)Deep‐learning‐based signal enhancement is an effective way to recover high‐resolution details from a low‐resolution chromatin contact map. However, due to computational challenges, existing methods commonly divide up the contact map into small patches and create artificial discontinuities at patch boundaries.
Li Q +6 more
europepmc +2 more sources
Analysis of oral microbiome on temporary anchorage devices under different periodontal conditions
Progress in Orthodontics, 2023 Background Temporary anchorage devices (TADs) are maximum anchorages that have been widely used in orthodontic treatment. The aim of the study was to uncover whether a history of periodontitis would influence microbiome colonization on the TAD surface ...
Ningrui Zhao +6 more
doaj +1 more source
Making sense of the linear genome, gene function and TADs
Epigenetics & Chromatin, 2022 Background Topologically associating domains (TADs) are thought to act as functional units in the genome. TADs co-localise genes and their regulatory elements as well as forming the unit of genome switching between active and inactive compartments.
Helen S. Long +5 more
doaj +1 more source
Nature Reviews Genetics, 2019 A study in Nature Genetics shows that genomic rearrangements that cause extensive changes to chromatin topology do not alter expression for the majority of genes.
openaire +2 more sources
BMC Biology, 2018 Background The human genome is highly organized in the three-dimensional nucleus. Chromosomes fold locally into topologically associating domains (TADs) defined by increased intra-domain chromatin contacts.
Jan Krefting +2 more
doaj +1 more source
CTCF as a boundary factor for cohesin-mediated loop extrusion: evidence for a multi-step mechanism
Nucleus, 2020 Mammalian genome structure is closely linked to function. At the scale of kilobases to megabases, CTCF and cohesin organize the genome into chromatin loops.
Anders S. Hansen
doaj +1 more source
TADKB: Family classification and a knowledge base of topologically associating domains
BMC Genomics, 2019 Background Topologically associating domains (TADs) are considered the structural and functional units of the genome. However, there is a lack of an integrated resource for TADs in the literature where researchers can obtain family classifications and ...
Tong Liu +7 more
doaj +1 more source
Stability of orthodontic anchoring devices: a narrative review [PDF]
Romanian Journal of StomatologyBackground and objectives. Temporary anchoring devices (TADs) are essential for controlling unwanted reactive movements in teeth because orthodontic treatments require effective anchorage to control tooth movement.
Magdalena Enache +7 more
doaj +1 more source
, 2019 The transboundary diseases in camel are mainly linked to the regional camel meat market from Sahelian countries (from Mauritania to Somalia) to the Arabian peninsula and North Africa. Indeed, the camel flow in relationship with this market is based on live animals’ export. Because the camel trade can be formal and informal with interconnections between
openaire +2 more sources