Results 41 to 50 of about 10,207 (224)

Topologically Associating Domains and Regulatory Landscapes in Development, Evolution and Disease

Frontiers in Cell and Developmental Biology, 2021
Animal genomes are folded in topologically associating domains (TADs) that have been linked to the regulation of the genes they contain by constraining regulatory interactions between cis-regulatory elements and promoters. Therefore, TADs are proposed as
Juan J. Tena, José M. Santos-Pereira
doaj   +1 more source

Stem Cell Differentiation Disperses Transcriptional Clusters via a Conserved Surface‐Condensate Trajectory

Advanced Science, EarlyView.
Stem cell differentiation follows a conserved surface condensate trajectory: H3K27ac super enhancers nucleate large RNA polymerase II clusters that grow and unfold before transcriptional activity disperses them. This work reveals how biophysical forces at enhancer surfaces dynamically build and dismantle stem cell transcription hubs, reshaping cell ...
Tim Klingberg, Irina Wachter, Agnieszka Pancholi, Matthias Akyel, Yomna Gohar, Priya Kumar, Ana Miguel Fernandes, Yuzhi Bao, Alica Schmidt‐Heydt, Marcel Piepers, Alicia Günthel, Marcel Sobucki, Elisa Kämmer, Süheyla Eroğlu‐Kayıkçı, Stephan Allgeier, Sylvia Erhardt, Vasily Zaburdaev, Carmelo Ferrai, Lennart Hilbert   +18 more
wiley   +1 more source

Statistics of chromatin organization during cell differentiation revealed by heterogeneous cross-linked polymers

Nature Communications, 2019
Chromatin is folded into Topologically Associating domains (TADs), with the organization and folding hierarchy of the TADs being highly dynamic. Here the authors develop a parsimonious randomly cross-linked (RCL) polymer model that maps high frequency ...
O. Shukron, V. Piras, D. Noordermeer, D. Holcman   +3 more
doaj   +1 more source

Endpoint Evaluation of Temporary Anchorage Device Placement in Orthodontic Practice

International Dental Journal, 2023
Aim or Purpose: Short-term mini-implants or temporary anchorage devices (TAD) were used in Orthodontic practice in patients who require skeletal anchorage for tooth movement.
Prof Muralidhar Mupparapu, Prof Krishna Prasad Lingamaneni, Miss Nirel Gidanian, Dr Rebecca Muller, Dr Brooke Talsania   +4 more
doaj   +1 more source

Efficient Adsorption‐Based Direct Air Capture Via Triply Periodic Minimal Surface Architectures

Advanced Science, EarlyView.
Architected triply periodic minimal surface (TPMS) contactors reshape direct air capture by replacing straight‐channel diffusion limits with convection‐enhanced CO2 transport. Chaotic advection thins boundary layers and exposes fast adsorption sites, enabling 70%–75% more fast sites, 114% higher productivity, and 51.8% lower energy consumption than ...
Qingyang Shao, Zhuozhen Gan, Chengcheng Long, Man Zhang, Yihe Miao, Yuehui Li, Xuancan Zhu   +6 more
wiley   +1 more source

Current Challenges of Transcription Compartmentalization Research

Advanced Science, EarlyView.
Transcription factors, coactivators, and RNA polymerase II assemble into transcription compartments ranging from small, defined complexes to liquid‐like condensates. This review unifies these seemingly competing descriptions along a single continuum and asks what these compartments have been shown to do, and what they have not, revealing that the most ...
Thomas Quail, Sina Wittmann
wiley   +1 more source

Multi-feature clustering of CTCF binding creates robustness for loop extrusion blocking and Topologically Associating Domain boundaries

Nature Communications, 2023
Topologically Associating Domains (TADs) separate vertebrate genomes into insulated regulatory neighborhoods that focus genome-associated processes. TADs are formed by Cohesin-mediated loop extrusion, with many TAD boundaries consisting of clustered ...
Li-Hsin Chang, Sourav Ghosh, Andrea Papale, Jennifer M. Luppino, Mélanie Miranda, Vincent Piras, Jéril Degrouard, Joanne Edouard, Mallory Poncelet, Nathan Lecouvreur, Sébastien Bloyer, Amélie Leforestier, Eric F. Joyce, David Holcman, Daan Noordermeer   +14 more
doaj   +1 more source

A Personalized Haplotype‐Resolved Near‐Gapless Genome Framework for Somatic Variant Discovery in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A patient‐specific, haplotype‐resolved genome framework improves detection and interpretation of somatic variants in hepatocellular carcinoma. Using multi‐platform sequencing, the personalized assembly resolves complex regions including centromeres and MHC/HLA loci, enhances structural variant discovery, and links regulatory alterations to allele ...
Jiazheng Lin, Yao Xiao, Shuangzi Luo, Yifan Li, Wenfei Zhang, Xiaoyu Zhang, Xinyi Wang, Di Wu, Jieru Hong, Yongkun Luan, Xun Huang, Yixiu Wang, Ningbo Wu, Xiaoxiao Hu, Fei Zhao, Wei Li, Xiao Luo, Bi Shi   +17 more
wiley   +1 more source

New Zeolitic Imidazolate Framework‐Derived N‐Doped Carbon LiCl Composites for Sorption Thermal Batteries Utilizing Solar Energy

Carbon Energy, EarlyView.
New hierarchical ZIF‐derived nitrogen‐doped carbons (ZDCs) impregnated with LiCl are promising materials for sorption thermal batteries utilizing solar energy. This study examines the structural properties of ZDCs, the effect of LiCl loading, the enhancement of hydrothermal stability by nanoporous carbon, and the water adsorption properties of a series
Jan Marčec, Marija Švegovec, Matjaž Mazaj, Andraž Krajnc, Boštjan Genorio, Daniel Lager, Nataša Zabukovec Logar, Alenka Ristić   +7 more
wiley   +1 more source

Multivalent and Bidirectional Binding of Transcriptional Transactivation Domains to the MED25 Coactivator

Biomolecules, 2020
The human mediator subunit MED25 acts as a coactivator that binds the transcriptional activation domains (TADs) present in various cellular and viral gene-specific transcription factors.
Heather M. Jeffery, Robert O. J. Weinzierl   +1 more
doaj   +1 more source