Results 61 to 70 of about 10,725 (210)

The distributions of protein coding genes within chromatin domains in relation to human disease

Epigenetics & Chromatin, 2019
Background Our understanding of the nuclear chromatin structure has increased hugely during the last years mainly as a consequence of the advances in chromatin conformation capture methods like Hi-C.
Enrique M. Muro, Jonas Ibn-Salem, Miguel A. Andrade-Navarro   +2 more
doaj   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Structural basis for the preservation of a subset of topologically associating domains in interphase chromosomes upon cohesin depletion

eLife
Compartment formation in interphase chromosomes is a result of spatial segregation between euchromatin and heterochromatin on a few megabase pairs (Mbp) scale.
Davin Jeong, Guang Shi, Xin Li, D Thirumalai   +3 more
doaj   +1 more source

The effectiveness of low‐intensity mental health interventions for children and young people in England: a presentation and analysis of synthesised outcomes

Child and Adolescent Mental Health, EarlyView.
Background Despite rapid national implementation of the new low‐intensity (LI) children and young people's (CYP) mental health (MH) workforce, outcomes have not been synthesised at scale. Methods This paper presents retrospective, uncontrolled routine outcome data collected between July 2017 and May 2025 from LI services across several regions of ...
Susanna Payne, Deepa Mavji, Caroline Stokes, Jessica Richardson, Jonathan Parker, Catherine Gallop, Hollie Gay, Katy Snitter, Elizabeth Deacon, Lili Ly, Vicki Curry, Markku Wood, Tyler Lewis, Cara Miller, Nicola Abraham, Elizabeth Turnbull, Melika Janbakhsh, Nicholas Smith, Helen Barker, Sadie Williams, Laura Bowyer, Kellie Jacques, Mike Turnbull, Jessica Collins, Alisa Kurina, Natalie Fabian, Anne Matthews, Barbara Evetts, Jeevan Kang, Alison Wheeler, Peter Fonagy   +30 more
wiley   +1 more source

Practical Guidance for the Use of Control‐IQ Technology During Physical Activity and Exercise

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Introduction Use of automated insulin delivery (AID) systems during physical activity and exercise (PA) is safe and associated with improved glucose outcomes when compared with insulin pump therapy in manual mode and insulin pen therapy, provided that appropriate adjustments to insulin doses and carbohydrate intake are ensured. Aim This expert
Sergio Di Molfetta, Jonida Haxhi, Francesca Franco, Giuseppe Papa, Andrea Rigamonti, Michael C. Riddell, Dessi P. Zaharieva, Othmar Moser   +7 more
wiley   +1 more source

TOP1MT rs2293925 is an enhancer‐active regulatory SNP that shapes mitochondrial R‐loop dynamics

The FEBS Journal, EarlyView.
This study shows how a common genetic variant of mitochondrial topoisomerase 1 (TOP1MT rs2293925) can influence mitochondrial gene regulation, DNA topology, and formation of noncanonical nucleic acid structures such as R‐loops. By linking this enhancer‐active variant to mitochondrial nucleic acid stress in cellular contexts relevant to amyotrophic ...
Dóra Varga, Zsolt Ráduly, Beáta Boros‐Oláh, Éva Nagy, Zsolt Karányi, László Halász, Bálint László Bálint, György Vámosi, Emese Tóth, Péter Bai, Serena Santangelo, Patrizia Bossolasco, Antonia Ratti, Vincent Géli, Yves Pommier, Lóránt Székvölgyi   +15 more
wiley   +1 more source

DiffDomain enables identification of structurally reorganized topologically associating domains

Nature Communications
Topologically associating domains (TADs) are critical structural units in three-dimensional genome organization of mammalian genome. Dynamic reorganizations of TADs between health and disease states are associated with essential genome functions. However,
Dunming Hua, Ming Gu, Xiao Zhang, Yanyi Du, Hangcheng Xie, Li Qi, Xiangjun Du, Zhidong Bai, Xiaopeng Zhu, Dechao Tian   +9 more
doaj   +1 more source

5C analysis of the Epidermal Differentiation Complex locus reveals distinct chromatin interaction networks between gene-rich and gene-poor TADs in skin epithelial cells.

PLoS Genetics, 2017
Mammalian genomes contain several dozens of large (>0.5 Mbp) lineage-specific gene loci harbouring functionally related genes. However, spatial chromatin folding, organization of the enhancer-promoter networks and their relevance to Topologically ...
Krzysztof Poterlowicz, Joanne L Yarker, Igor Malashchuk, Brian R Lajoie, Andrei N Mardaryev, Michal R Gdula, Andrey A Sharov, Terumi Kohwi-Shigematsu, Vladimir A Botchkarev, Michael Y Fessing   +9 more
doaj   +1 more source

UbiB proteins mediate an ATP‐dependent decarboxylation step in bacterial ubiquinone biosynthesis

The FEBS Journal, EarlyView.
UbiB proteins are atypical protein kinase‐like enzymes essential for ubiquinone biosynthesis. Here, we demonstrate that bacterial UbiB proteins catalyze the O2‐dependent decarboxylation of ubiquinone precursors, a process linked to their ATPase activity.
Katayoun Kazemzadeh, Bruno Faivre, Sophie‐Carole Chobert, Martial Rey, Sophie S. Abby, Julie Michaud, Tuan‐Anh Dinh, Alexandre Chilin, Olivier Lerouxel, Marc Fontecave, Fabien Pierrel, Murielle Lombard, Ludovic Pelosi   +12 more
wiley   +1 more source

C‐type cyclin CycC1;1 delays leaf senescence by interacting with and inhibiting MYC2 in Arabidopsis

Journal of Integrative Plant Biology, EarlyView.
The C‐type cyclin CycC1;1 interacts with MYC2 and MED25 to block their association and RNA polymerase II recruitment, thereby repressing senescence‐associated gene expression and delaying leaf senescence in Arabidopsis. Unlike jasmonic acid‐inducible JAZ repressors, CycC1;1 operates independently of jasmonic acid signaling, representing an ...
Cai‐Yi Liao, Xiao‐Li Huang, Lin Li, Guo‐Mao Liu, Kai‐Kai Lu, Hong Yang, Song‐Qi Li, Peng‐Wei Jing, Ru‐Feng Song, Wen‐Cheng Liu   +9 more
wiley   +1 more source