Results 61 to 70 of about 13,596 (270)

Breaking TADs: How Alterations of Chromatin Domains Result in Disease [PDF]

, 2016
Spatial organization is an inherent property of the vertebrate genome to accommodate the roughly 2m of DNA in the nucleus of a cell. In this nonrandom organization, topologically associating domains (TADs) emerge as a fundamental structural unit that is ...
Spielmann, M., Lupiáñez, D.G., Lupiáñez, D., Mundlos, S.   +3 more
core   +1 more source

Multi-feature clustering of CTCF binding creates robustness for loop extrusion blocking and Topologically Associating Domain boundaries

Nature Communications, 2023
Topologically Associating Domains (TADs) separate vertebrate genomes into insulated regulatory neighborhoods that focus genome-associated processes. TADs are formed by Cohesin-mediated loop extrusion, with many TAD boundaries consisting of clustered ...
Li-Hsin Chang, Sourav Ghosh, Andrea Papale, Jennifer M. Luppino, Mélanie Miranda, Vincent Piras, Jéril Degrouard, Joanne Edouard, Mallory Poncelet, Nathan Lecouvreur, Sébastien Bloyer, Amélie Leforestier, Eric F. Joyce, David Holcman, Daan Noordermeer   +14 more
doaj   +1 more source

Treatment of adult class II division 2 with deep bite using Forsus appliance and intrusion with TADs

Journal of Orthodontic Science
This case report details the treatment of a 23-year-old female patient with Class II division 2 malocclusion with a Class II skeletal base due to a retrognathic mandible. The condition was further complicated by a complete overbite, absence of tooth #36,
Amani Alkhamees
doaj   +1 more source

Temporary anchorage devices in the infrazygomatic crest: Systematic review of placement guidelines and clinical case series

Advances in Oral and Maxillofacial Surgery
Objectives: This study aimed to evaluate the anatomical guidelines and clinical protocols for the safe placement of temporary anchorage devices (TADs) in the infrazygomatic crest (IZC), comparing conventional manual insertion techniques with template ...
Luisa Limongelli, Gianna Dipalma, Gianfranco Favia, Maral Di Giulio Cesare, Marialuisa Longo, Sharon Di Serio, Irma Trilli, Laura Ferrante, Francesco Inchingolo, Daniela Di Venere, Vito Crincoli, Andrea Palermo, Angelo Michele Inchingolo, Alessio Danilo Inchingolo   +13 more
doaj   +1 more source

Multivalent and Bidirectional Binding of Transcriptional Transactivation Domains to the MED25 Coactivator

Biomolecules, 2020
The human mediator subunit MED25 acts as a coactivator that binds the transcriptional activation domains (TADs) present in various cellular and viral gene-specific transcription factors.
Heather M. Jeffery, Robert O. J. Weinzierl   +1 more
doaj   +1 more source

DavidGCooper/WYFL-tADs: WYFL-tADs

<p>Initial release of the WYFL-tADs repository. Data and code for the analysis of transcriptional activation domains containing acidic and hydrophobic (W, F, Y, and L) amino acids.</p ...
DavidGCooper
core   +1 more source

Methods for the Analysis of Topologically Associating Domains (TADs)

, 2021
Chromatin folding in the 3D space of the nucleus can be explored through high-throughput chromosome conformation capture (Hi-C) approaches. These experiments quantify the number of interactions between any pair of genomic loci in the genome and, thus ...
Giovanni Ciriello, Tavernari, D., Zufferey, M., Ciriello, G., Marie Zufferey, Daniele Tavernari   +5 more
core   +1 more source

New Zeolitic Imidazolate Framework‐Derived N‐Doped Carbon LiCl Composites for Sorption Thermal Batteries Utilizing Solar Energy

Carbon Energy, EarlyView.
New hierarchical ZIF‐derived nitrogen‐doped carbons (ZDCs) impregnated with LiCl are promising materials for sorption thermal batteries utilizing solar energy. This study examines the structural properties of ZDCs, the effect of LiCl loading, the enhancement of hydrothermal stability by nanoporous carbon, and the water adsorption properties of a series
Jan Marčec, Marija Švegovec, Matjaž Mazaj, Andraž Krajnc, Boštjan Genorio, Daniel Lager, Nataša Zabukovec Logar, Alenka Ristić   +7 more
wiley   +1 more source

Dual Regulatory Functions of Classical Zinc Finger Clusters from Myeloid Zinc Finger‐1

Chemistry – A European Journal, EarlyView.
The classical zinc finger (ZF) protein MZF1 uses two ZF clusters to achieve metal‐dependent and gene‐specific promoter recognition. The differential redox stability and modular utilization of the two ZF clusters enable MZF1 to regulate cerebrovascular, neuronal, and cancer‐related transcriptional programs.
Yunha Hwang, Yerim Park, Nohwan Park, Heeju Noh, Hyun Goo Kang, Seung Jae Lee   +5 more
wiley   +1 more source

British Orthodontic Society national audit of temporary anchorage devices (TADs):report of the first thousand TADs placed

, 2015
Objective: To provide data from the British Orthodontic Society (BOS) national clinical audit on temporary anchorage device (TAD) use following the recommendations of the National Institute for Health and Clinical Excellence (NIHCE) Design and setting ...
Bearn, David R., Alharbi, Fahad
core   +1 more source