Results 71 to 80 of about 13,596 (270)
Chemistry – A European Journal, EarlyView.Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley +1 more source
A NICE approach to temporary anchorage devices (TADs)
, 2009 This paper will give a background to NICE: including its origins, dental subjects in which it it has taken some interest and specific interest in temporary anchorage devices (TADs).
Alison Murray, Jonathan Sandler
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From Caffeine to Aspirin: Everyday Molecules as Triggers for Genetically Encoded Proximity Systems
Chemistry – A European Journal, EarlyView.This Perspective article highlights how familiar dietary ingredients and over‐the‐counter (OTC) drugs (such as caffeine and its metabolites, SA, and aspirin) can be repurposed as clinically translatable chemical triggers for genetically encoded proximity systems.
Mingguang Cui +5 more
wiley +1 more source
The distributions of protein coding genes within chromatin domains in relation to human disease
Epigenetics & Chromatin, 2019 Background Our understanding of the nuclear chromatin structure has increased hugely during the last years mainly as a consequence of the advances in chromatin conformation capture methods like Hi-C.
Enrique M. Muro +2 more
doaj +1 more source
An Analytical Design Model of a Vacuum Pressure Swing Adsorption Process for Biogas Upgrading
Chemie Ingenieur Technik, EarlyView.A steady‐state model was developed for a vacuum pressure swing adsorption (VPSA) process comprising adsorption, depressurization, and evacuation steps. The resulting analytical plant design model provides the optimal adsorber height required to achieve a target product purity with maximum bed utilization.
Thomas Welter +3 more
wiley +1 more source
Deciphering chromatin domain, domain community and chromunity for 3D genome maps with Mactop
Communications BiologyAdvanced high-throughput chromosome conformation capture techniques, like Hi-C, reveal genome organization into structural units like topologically associating domains (TADs), which are crucial in gene expression regulation.
Ran Duan +4 more
doaj +1 more source
Movement Disorders, EarlyView.Abstract Background NKX2‐1–related disorders (NKX2‐1‐RDs) classically present with a triad of neurological, endocrine, and pulmonary manifestations, including benign hereditary chorea. However, in a fraction of patients, NKX2‐1 coding variants are not detected, and variants outside the NKX2‐1 locus have been reported.
Robin Wijngaard +33 more
wiley +1 more source
eLifeCompartment formation in interphase chromosomes is a result of spatial segregation between euchromatin and heterochromatin on a few megabase pairs (Mbp) scale.
Davin Jeong +3 more
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Annex: exemples d'interrelacions de TADs
, 2012 El present document té com a objectiu mostrar un seguit d'exemples d'interrelacions de TADs. No es pretén entrar en la presa de decisions prèvia a l'elecció de TADs, sinó que en base a un escenari predeterminat, es volen exposar des d'una vessant ...
Blasco Planesas, Jordi
core
Senotherapeutics for Knee Osteoarthritis
Medicinal Research Reviews, EarlyView.ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman +6 more
wiley +1 more source