Results 71 to 80 of about 10,725 (210)

Plant cis‐regulatory grammar: Decoding the multidimensional code of transcriptional regulation for programmable crop engineering

Journal of Integrative Plant Biology, EarlyView.
This review decodes the grammar of plant cis‐regulatory elements, revealing that their function emerges from sequence, chromatin accessibility, 3D topology, and cell type context. It highlights how single‐cell omics, CRISPR dissection, and AI‐driven design converge to enable predictive engineering and crop improvement. ABSTRACT Cis‐regulatory elements (
Libin Zhang, Maoteng Li
wiley   +1 more source

Current situation, trends, and challenges navigating temporary anchorage devices usage among orthodontists in China: a comprehensive multi-center survey

BMC Oral Health
Background The temporary anchorage devices (TADs) are presently a viable and popular treatment option for orthodontics all over the world. However, there is a lack of investigation and research on its application among orthodontists in China.
Zining Chen, Hao Wang, Qianwen Li, Ningrui Zhao, Jieni Zhang, Xuedong Wang   +5 more
doaj   +1 more source

Cytotoxicity of orthodontic temporary anchorage devices on human periodontal ligament fibroblasts in vitro

Clinical and Experimental Dental Research, 2019
Objectives The objective of this study is to test cytotoxicity of four brands of commercially available orthodontic temporary anchorage devices (TADs).
Zhibin Chen, Manika Patwari, Dawei Liu
doaj   +1 more source

A Population Pharmacokinetic Model of Gentamicin in Hospitalized Neonatal Foals

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Information on safe and effective gentamicin dosing in foals is limited. This study aimed to provide guidance regarding optimal dosing regimens by means of a population pharmacokinetic (popPK) model. Gentamicin plasma concentration of 290 samples from 72 hospitalized foals (≤ 14 days old), treated with intravenous (IV) gentamicin, was measured
Astrid J. van den Brom‐Spierenburg, Esther A. Winter, Mathijs J. P. Theelen, Ingeborg M. van Geijlswijk, Cornélie M. Westermann, Marianne M. Sloet van Oldruitenborgh‐Oosterbaan, Tim Florschütz, Johannes C. Vendrig, Esther W. Siegers, Kim de Graaf, Marc Cherlet, Mathias Devreese, Ronette Gehring   +12 more
wiley   +1 more source

Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation

Cell Reports, 2019
Summary: Somatic hypermutation (SHM) introduces point mutations into immunoglobulin (Ig) genes but also causes mutations in other parts of the genome.
Filip Senigl, Yaakov Maman, Ravi K. Dinesh, Jukka Alinikula, Rashu B. Seth, Lubomira Pecnova, Arina D. Omer, Suhas S.P. Rao, David Weisz, Jean-Marie Buerstedde, Erez Lieberman Aiden, Rafael Casellas, Jiri Hejnar, David G. Schatz   +13 more
doaj   +1 more source

How LLMs might think

Mind &Language, EarlyView.
Do large language models (“LLMs”) think? Daniel Stoljar and Zhihe Vincent Zhang have recently developed an argument from rationality for the claim that LLMs do not think. We contend, however, that the argument from rationality not only falters, but leaves open an intriguing possibility: that LLMs engage only in arational, associative forms of thinking ...
Joseph Gottlieb, Ethan Kemp, Matthew Trager   +2 more
wiley   +1 more source

Comparative Evaluation of Treatment Effectiveness in Skeletal Class III Malocclusion: Surgery‐First Approach Using Clear Aligners Versus Fixed Appliances

Orthodontics &Craniofacial Research, EarlyView.
ABSTRACT Objective This study aimed to assess treatment outcomes, identify predictors of relapse in skeletal Class III patients treated with the surgery‐first approach (SFA), comparing fixed appliances (FA) with invisalign clear aligners (CA). Materials and Methods Forty adult patients treated with bimaxillary surgery and SFA were retrospectively ...
Yang Zhou, Xiaojing Liu, Zili Li, Bingshuang Zou   +3 more
wiley   +1 more source

Effects Produced by Fixed Functional Appliances With and Without Skeletal Anchorage for the Treatment of Class II Malocclusion in the Growing Patient: A Review of Systematic Reviews

Orthodontics &Craniofacial Research, EarlyView.
ABSTRACT To summarise the scientific evidence from systematic reviews on the differences between fixed functional appliances (FFA) with and without skeletal anchorage for the treatment of Class II malocclusion in growing patients. A systematic search on six major databases was performed.
Valentina Rutili, Michele Nieri, Veronica Giuntini, Ersilia Vaccari, Lorenzo Franchi   +4 more
wiley   +1 more source

The Impact of Malocclusion Severity on the Number of Prescribed, Used Aligners and Treatment Duration; A Retrospective, Singe‐Centre, Cohort Study

Orthodontics &Craniofacial Research, EarlyView.
ABSTRACT Objective To assess the impact of baseline malocclusion severity on the number of prescribed, used aligners and treatment duration. Materials and Methods An unrestricted, independent search was conducted on the Invisalign ClinCheck database of a private practice for patients without any missing anterior teeth and whose treatment was finished ...
Angeliki Anna Gkinosati, Candice Durgnat, Effimia Koumpia, Nikolaos Pandis, Christodoulos Laspos, Alexandra K. Papadopoulou   +5 more
wiley   +1 more source

Prevalence and risk factors of thoracic aortic dilatation detected incidentally in adjuvant radiotherapy planning CT scans in patients with breast cancer

Scientific Reports
Thoracic aortic dilatations (TADs) are commonly detected incidentally. A TAD may develop into aortic aneurysm and subsequently lead to aortic dissection, a highly lethal condition.
Aada Lattu, Petteri Kauhanen, Ari Mennander, Marja Hedman, Mona Laaksonen, Irina Rinta-Kiikka, Tanja Skyttä, Otso Arponen   +7 more
doaj   +1 more source