Results 11 to 20 of about 110,305 (278)

Engineering 3D genome organization [PDF]

Nature Reviews Genetics, 2021
Cancers and developmental disorders are associated with alterations in the 3D genome architecture in space and time (the fourth dimension). Mammalian 3D genome organization is complex and dynamic and plays an essential role in regulating gene expression and cellular function.
Haifeng Wang, Mengting Han, Lei S Qi
exaly   +5 more sources

DNA Methylation Directs Polycomb-Dependent 3D Genome Re-organization in Naive Pluripotency [PDF]

Cell Reports, 2019
Summary: The DNA hypomethylation that occurs when embryonic stem cells (ESCs) are directed to the ground state of naive pluripotency by culturing in two small molecule inhibitors (2i) results in redistribution of polycomb (H3K27me3) away from its target ...
Katy McLaughlin, Ilya M. Flyamer, John P. Thomson, Heidi K. Mjoseng, Ruchi Shukla, Iain Williamson, Graeme R. Grimes, Robert S. Illingworth, Ian R. Adams, Sari Pennings, Richard R. Meehan, Wendy A. Bickmore   +11 more
doaj   +4 more sources

3D genome organization contributes to genome instability at fragile sites [PDF]

Nature Communications, 2020
Common fragile sites are regions susceptible to replication stress and are prone to chromosomal instability. Here, the authors, by analyzing the contribution of 3D chromatin organization, identify and characterize a fragility signature and precisely map ...
Dan Sarni, Takayo Sasaki, Michal Irony Tur-Sinai, Karin Miron, Juan Carlos Rivera-Mulia, Brian Magnuson, Mats Ljungman, David M. Gilbert, Batsheva Kerem   +8 more
doaj   +3 more sources

Integrative studies of 3D genome organization and chromatin structure

Current Opinion in Structural Biology, 2022
International audienceThe structural organization of the genome is emerging as a crucial regulator of the cell state, affecting gene transcription, DNA replication, and repair.
Di Stefano, Marco, Cavalli, Giacomo
core   +3 more sources

3D genome organization and its study in livestock breeding

Journal of Integrative Agriculture
Eukaryotic genomes are hierarchically packaged into cell nucleus, affecting gene regulation. The genome is organized into multiscale structural units, including chromosome territories, compartments, topologically associating domains (TADs), and DNA loops.
Jie Cheng, Xiukai Cao, Shengxuan Wang, Jiaqiang Zhang, Binglin Yue, Xiaoyan Zhang, Yongzhen Huang, Xianyong Lan, Gang Ren, Hong Chen   +9 more
doaj   +2 more sources

3D genome organization during lymphocyte development and activation [PDF]

Briefings in Functional Genomics, 2019
Chromosomes have a complex three-dimensional (3D) architecture comprising A/B compartments, topologically associating domains and promoter-enhancer interactions.
van Schoonhoven, A. (Anne), Huylebroeck, D. (Danny), Hendriks, R.W. (Rudi), Stadhouders, R. (Ralph)   +3 more
core   +5 more sources

3C-BASED METHODS FOR 3D GENOME ORGANIZATION ANALYSIS

Вавиловский журнал генетики и селекции, 2014
The 3D organization of an eukaryotic genome plays an important role in nuclear gene expression. Until recently, studies of this organization were limited by light microscopy and electron microscopy methods.
N. R. Battulin, V. S. Fishman, Yu. L. Orlov, A. G. Menzorov, D. A. Afonnikov, O. L. Serov   +5 more
doaj   +1 more source

Identifying 3D Genome Organization in Diploid Organisms via Euclidean Distance Geometry

SIAM Journal on Mathematics of Data Science, 2022
| openaire: EC/H2020/748354/EU//NonnegativeRankThe spatial organization of the genome in the cell nucleus plays an important role for gene regulation, replication of the deoxyribonucleic acid (DNA), and genomic integrity.
Uhler, Caroline, Kubjas, Kaie, Sun, Lawrence J, Belyaeva, Anastasiya, Sun, Lawrence J.   +4 more
core   +6 more sources

The interplay of 3D genome organization with UV-induced DNA damage and repair. [PDF]

J Biol Chem, 2023
The 3D organization of the eukaryotic genome is crucial for various cellular processes such as gene expression and epigenetic regulation, as well as for maintaining genome integrity.
Akköse Ü, Adebali O.
europepmc   +2 more sources

Folding Features and Dynamics of 3D Genome Architecture in Plant Fungal Pathogens

Microbiology Spectrum, 2022
The folding and dynamics of three-dimensional (3D) genome organization are fundamental for eukaryotes executing genome functions but have been largely unexplored in nonmodel fungi.
Chongjing Xia, Liang Huang, Jie Huang, Hao Zhang, Ying Huang, Moussa Benhamed, Meinan Wang, Xianming Chen, Min Zhang, Taiguo Liu, Wanquan Chen   +10 more
doaj   +1 more source