Results 11 to 20 of about 109,316 (244)
Engineering 3D genome organization [PDF]
Nature Reviews Genetics, 2021 Cancers and developmental disorders are associated with alterations in the 3D genome architecture in space and time (the fourth dimension). Mammalian 3D genome organization is complex and dynamic and plays an essential role in regulating gene expression and cellular function.
Lei S Qi, Haifeng Wang, Mengting Han
exaly +5 more sources
3D genome organization contributes to genome instability at fragile sites [PDF]
Nature Communications, 2020 Common fragile sites are regions susceptible to replication stress and are prone to chromosomal instability. Here, the authors, by analyzing the contribution of 3D chromatin organization, identify and characterize a fragility signature and precisely map ...
Dan Sarni +8 more
doaj +3 more sources
Folding Features and Dynamics of 3D Genome Architecture in Plant Fungal Pathogens
Microbiology Spectrum, 2022 The folding and dynamics of three-dimensional (3D) genome organization are fundamental for eukaryotes executing genome functions but have been largely unexplored in nonmodel fungi.
Chongjing Xia +10 more
doaj +1 more source
3D genomic organization in cancers
Quantitative Biology, 2023 BackgroundThe hierarchical three‐dimensional (3D) architectures of chromatin play an important role in fundamental biological processes, such as cell differentiation, cellular senescence, and transcriptional regulation. Aberrant chromatin 3D structural alterations often present in human diseases and even cancers, but their underlying mechanisms remain ...
Junting Wang 0003 +4 more
openaire +2 more sources
Three-dimensional chromatin architecture in plants – General features and novelties
European Journal of Cell Biology, 2023 Research on the three-dimensional (3D) structure of the genome and its distribution within the nuclear space has made a big leap in the last two decades.
Edouard Tourdot, Stefan Grob
doaj +1 more source
Mechanical determinants of chromatin topology and gene expression
Nucleus, 2022 The compaction of linear DNA into micrometer-sized nuclear boundaries involves the establishment of specific three-dimensional (3D) DNA structures complexed with histone proteins that form chromatin.
Rajiv Kumar Jha +2 more
doaj +1 more source
Chromatin insulators in gene regulation and 3D genome organization. [PDF]
Biochem Soc TransThe human genome attains an amazing spatial organization in the packaging of 2 m of DNA into a 10-μm nucleus. Such structural organization is achieved by the folding of chromatin and the regulation exerted by architectural proteins such as insulators. Chromatin insulators are boundary elements of the genome that, through enhancing blocking activities ...
Sultana H, Kunar R, Matera AG.
europepmc +4 more sources
The Functional 3D Organization of Unicellular Genomes [PDF]
Scientific Reports, 2019 AbstractGenome conformation capture techniques permit a systematic investigation into the functional spatial organization of genomes, including functional aspects like assessing the co-localization of sets of genomic elements. For example, the co-localization of genes targeted by a transcription factor (TF) within a transcription factory.
Shay Ben-Elazar +2 more
openaire +2 more sources
Novel biological insights revealed from the investigation of multiscale genome architecture
Computational and Structural Biotechnology Journal, 2023 Gene expression and cell fate determination require precise and coordinated epigenetic regulation. The complex three-dimensional (3D) genome organization plays a critical role in transcription in myriad biological processes. A wide range of architectural
Tianyi Ding, He Zhang
doaj +1 more source
Nucleosome-level 3D organization of the genome [PDF]
Biochemical Society Transactions, 2018 Nucleosomes are the unitary structures of chromosome folding, and their arrangements are intimately coupled to the regulation of genome activities. Conventionally, structural analyses using electron microscopy and X-ray crystallography have been used to study such spatial nucleosome arrangements.
Masae, Ohno +2 more
openaire +2 more sources