Results 11 to 20 of about 4,825,767 (247)

DNA methylation is required to maintain both DNA replication timing precision and 3D genome organization integrity [PDF]

Cell Reports, 2021
Summary: DNA replication timing and three-dimensional (3D) genome organization are associated with distinct epigenome patterns across large domains. However, whether alterations in the epigenome, in particular cancer-related DNA hypomethylation, affects ...
Qian Du, Grady C. Smith, Phuc Loi Luu, James M. Ferguson, Nicola J. Armstrong, C. Elizabeth Caldon, Elyssa M. Campbell, Shalima S. Nair, Elena Zotenko, Cathryn M. Gould, Michael Buckley, Kee-Ming Chia, Neil Portman, Elgene Lim, Dominik Kaczorowski, Chia-Ling Chan, Kirston Barton, Ira W. Deveson, Martin A. Smith, Joseph E. Powell, Ksenia Skvortsova, Clare Stirzaker, Joanna Achinger-Kawecka, Susan J. Clark   +23 more
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DNA Methylation Directs Polycomb-Dependent 3D Genome Re-organization in Naive Pluripotency [PDF]

Cell Reports, 2019
Summary: The DNA hypomethylation that occurs when embryonic stem cells (ESCs) are directed to the ground state of naive pluripotency by culturing in two small molecule inhibitors (2i) results in redistribution of polycomb (H3K27me3) away from its target ...
Katy McLaughlin, Ilya M. Flyamer, John P. Thomson, Heidi K. Mjoseng, Ruchi Shukla, Iain Williamson, Graeme R. Grimes, Robert S. Illingworth, Ian R. Adams, Sari Pennings, Richard R. Meehan, Wendy A. Bickmore   +11 more
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3C-BASED METHODS FOR 3D GENOME ORGANIZATION ANALYSIS

Вавиловский журнал генетики и селекции, 2014
The 3D organization of an eukaryotic genome plays an important role in nuclear gene expression. Until recently, studies of this organization were limited by light microscopy and electron microscopy methods.
N. R. Battulin, V. S. Fishman, Yu. L. Orlov, A. G. Menzorov, D. A. Afonnikov, O. L. Serov   +5 more
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3D genome organization and its study in livestock breeding

Journal of Integrative Agriculture
Eukaryotic genomes are hierarchically packaged into cell nucleus, affecting gene regulation. The genome is organized into multiscale structural units, including chromosome territories, compartments, topologically associating domains (TADs), and DNA loops.
Jie Cheng, Xiukai Cao, Shengxuan Wang, Jiaqiang Zhang, Binglin Yue, Xiaoyan Zhang, Yongzhen Huang, Xianyong Lan, Gang Ren, Hong Chen   +9 more
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Folding Features and Dynamics of 3D Genome Architecture in Plant Fungal Pathogens

Microbiology Spectrum, 2022
The folding and dynamics of three-dimensional (3D) genome organization are fundamental for eukaryotes executing genome functions but have been largely unexplored in nonmodel fungi.
Chongjing Xia, Liang Huang, Jie Huang, Hao Zhang, Ying Huang, Moussa Benhamed, Meinan Wang, Xianming Chen, Min Zhang, Taiguo Liu, Wanquan Chen   +10 more
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Three-dimensional chromatin architecture in plants – General features and novelties

European Journal of Cell Biology, 2023
Research on the three-dimensional (3D) structure of the genome and its distribution within the nuclear space has made a big leap in the last two decades.
Edouard Tourdot, Stefan Grob
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Mechanical determinants of chromatin topology and gene expression

Nucleus, 2022
The compaction of linear DNA into micrometer-sized nuclear boundaries involves the establishment of specific three-dimensional (3D) DNA structures complexed with histone proteins that form chromatin.
Rajiv Kumar Jha, David Levens, Fedor Kouzine   +2 more
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Novel biological insights revealed from the investigation of multiscale genome architecture

Computational and Structural Biotechnology Journal, 2023
Gene expression and cell fate determination require precise and coordinated epigenetic regulation. The complex three-dimensional (3D) genome organization plays a critical role in transcription in myriad biological processes. A wide range of architectural
Tianyi Ding, He Zhang
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CTCF: A misguided jack-of-all-trades in cancer cells

Computational and Structural Biotechnology Journal, 2022
The emergence and progression of cancers is accompanied by a dysregulation of transcriptional programs. The three-dimensional (3D) organization of the human genome has emerged as an important multi-level mediator of gene transcription and regulation.
Julie Segueni, Daan Noordermeer
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3D disorganization and rearrangement of genome provide insights into pathogenesis of NAFLD by integrated Hi-C, Nanopore, and RNA sequencing

Acta Pharmaceutica Sinica B, 2021
The three-dimensional (3D) conformation of chromatin is integral to the precise regulation of gene expression. The 3D genome and genomic variations in non-alcoholic fatty liver disease (NAFLD) are largely unknown, despite their key roles in cellular ...
Lina Xu, Lianhong Yin, Yan Qi, Xuemei Tan, Meng Gao, Jinyong Peng   +5 more
doaj   +1 more source