Results 11 to 20 of about 5,043,774 (177)

Engineering 3D Genome Organization [PDF]

Nature Reviews Genetics, 2021
Cancers and developmental disorders are associated with alterations in the 3D genome architecture in space and time (the fourth dimension). Mammalian 3D genome organization is complex and dynamic and plays an essential role in regulating gene expression and cellular function.
Lei S Qi, Haifeng Wang, Mengting Han
exaly   +5 more sources

DNA methylation is required to maintain both DNA replication timing precision and 3D genome organization integrity [PDF]

Cell Reports, 2021
Summary: DNA replication timing and three-dimensional (3D) genome organization are associated with distinct epigenome patterns across large domains. However, whether alterations in the epigenome, in particular cancer-related DNA hypomethylation, affects ...
Qian Du, Grady C. Smith, Phuc Loi Luu, James M. Ferguson, Nicola J. Armstrong, C. Elizabeth Caldon, Elyssa M. Campbell, Shalima S. Nair, Elena Zotenko, Cathryn M. Gould, Michael Buckley, Kee-Ming Chia, Neil Portman, Elgene Lim, Dominik Kaczorowski, Chia-Ling Chan, Kirston Barton, Ira W. Deveson, Martin A. Smith, Joseph E. Powell, Ksenia Skvortsova, Clare Stirzaker, Joanna Achinger-Kawecka, Susan J. Clark   +23 more
doaj   +2 more sources

Comparative 3D genome organization in apicomplexan parasites [PDF]

Proceedings of the National Academy of Sciences, 2019
The positioning of chromosomes in the nucleus of a eukaryotic cell is highly organized and has a complex and dynamic relationship with gene expression.
Mamoun, CB, Andolina, C, Tewari, R, McGovern, KE, Tewari, Rita, Bunnik, Evelien M, Ross, Leila S, Ben Mamoun, Choukri, Venkat, A, Prudhomme, J, Lawres, L, Fidock, DA, Wilson, EH, Venkat, Aarthi, Galinski, Mary R, Worth, D, Sinnis, P, Brady, D, Nosten, F, Shao, Jianlin, Sinnis, Photini, Ross, LS, Lapp, SA, Ay, Ferhat, Le Roch, KG, Brady, Declan, Wilson, Emma H, Galinski, MR, Le Roch, Karine G, Lapp, Stacey A, Ay, F, Andolina, Chiara, Batugedara, Gayani, Shao, J, Lawres, Lauren, Nosten, Francois, Bunnik, EM, Batugedara, G, McGovern, Kathryn E, Worth, Danielle, Prudhomme, Jacques, Fidock, David A   +41 more
core   +9 more sources

3D genome organization contributes to genome instability at fragile sites [PDF]

Nature Communications, 2020
Common fragile sites are regions susceptible to replication stress and are prone to chromosomal instability. Here, the authors, by analyzing the contribution of 3D chromatin organization, identify and characterize a fragility signature and precisely map ...
Dan Sarni, Takayo Sasaki, Michal Irony Tur-Sinai, Karin Miron, Juan Carlos Rivera-Mulia, Brian Magnuson, Mats Ljungman, David M. Gilbert, Batsheva Kerem   +8 more
doaj   +3 more sources

3D Genome Engineering: Current Advances and Therapeutic Opportunities in Human Diseases

Research
Dynamic chromatin 3-dimensional (3D) conformation is a key mechanism regulating gene expression and cellular function during development and disease.
Xing Jiang, Xiaoli Wang, Song Shen, Shangguo Hou, Chen Yu   +4 more
doaj   +2 more sources

DNA Methylation Directs Polycomb-Dependent 3D Genome Re-organization in Naive Pluripotency [PDF]

Cell Reports, 2019
Summary: The DNA hypomethylation that occurs when embryonic stem cells (ESCs) are directed to the ground state of naive pluripotency by culturing in two small molecule inhibitors (2i) results in redistribution of polycomb (H3K27me3) away from its target ...
Katy McLaughlin, Ilya M. Flyamer, John P. Thomson, Heidi K. Mjoseng, Ruchi Shukla, Iain Williamson, Graeme R. Grimes, Robert S. Illingworth, Ian R. Adams, Sari Pennings, Richard R. Meehan, Wendy A. Bickmore   +11 more
doaj   +6 more sources

3C-BASED METHODS FOR 3D GENOME ORGANIZATION ANALYSIS

Вавиловский журнал генетики и селекции, 2014
The 3D organization of an eukaryotic genome plays an important role in nuclear gene expression. Until recently, studies of this organization were limited by light microscopy and electron microscopy methods.
N. R. Battulin, V. S. Fishman, Yu. L. Orlov, A. G. Menzorov, D. A. Afonnikov, O. L. Serov   +5 more
doaj   +1 more source

3D genome organization during lymphocyte development and activation [PDF]

Briefings in Functional Genomics, 2019
Chromosomes have a complex three-dimensional (3D) architecture comprising A/B compartments, topologically associating domains and promoter-enhancer interactions.
van Schoonhoven, A. (Anne), Huylebroeck, D. (Danny), Hendriks, R.W. (Rudi), Stadhouders, R. (Ralph)   +3 more
core   +5 more sources

3D genome organization and its study in livestock breeding

Journal of Integrative Agriculture
Eukaryotic genomes are hierarchically packaged into cell nucleus, affecting gene regulation. The genome is organized into multiscale structural units, including chromosome territories, compartments, topologically associating domains (TADs), and DNA loops.
Jie Cheng, Xiukai Cao, Shengxuan Wang, Jiaqiang Zhang, Binglin Yue, Xiaoyan Zhang, Yongzhen Huang, Xianyong Lan, Gang Ren, Hong Chen   +9 more
doaj   +2 more sources

An Algorithm for the Analysis of the 3D Spatial Organization of the Genome.

, 2020
We present an algorithm, and its MATLAB implementation, based on mathematical methods to detect and localize 3D multicolor DNA FISH spots in fluorescence cell image z-stacks.
Beatrice Bodega, Alice Cortesi, Laura Antonelli, Francesco Gregoretti, Gennaro Oliva, Bodega Beatrice, Antonelli Laura, Oliva Gennaro, Cortesi Alice, Gregoretti Francesco   +9 more
core   +4 more sources