Results 41 to 50 of about 5,043,774 (177)

The 3D Genome: From Structure to Function

, 2021
The genome is the most functional part of a cell, and genomic contents are organized in a compact three-dimensional (3D) structure. The genome contains millions of nucleotide bases organized in its proper frame. Rapid development in genome sequencing and
Ahmed Al-Harrasi, Tapan Kumar Mohanta, Awdhesh Kumar Mishra   +2 more
core   +1 more source

Principles of the 3D genome organization in malaria mosquitoes

, 2020
Poster "Principles of the 3D genome organization in malaria mosquitoes.
Varvara Lukyanchikova (8713636), Veniamin S. Fishman (3915167), Igor Sharakhov (5941565), Nariman R. Battulin (3915170), Alexander Tyapkin (8726452), Polina Belokopytova (8726454), Miroslav Nuriddinov (8726448)   +6 more
core   +1 more source

The CACTA transposon Bot1 played a major role in Brassica genome divergence and gene proliferation [PDF]

, 2008
We isolated and characterized a Brassica C genome-specific CACTA element, which was designated Bot1 (Brassica oleracea transposon 1). After analysing phylogenetic relationships, copy numbers and sequence similarity of Bot1 and Bot1 analogues in B ...
Joets, Johann, Moore, Jonathan D., Heslop-Harrison, J. (John), King , Graham J., Ryder, C. D., Heslop-Harrison, J. S., Joets, J., Bailey, John P., Moore, J., Ryder, Carol D., Bailey, J. P., Alix, K., Barker, G. C., King, G. J., Barker, Guy C., Alix, Karine   +15 more
core   +1 more source

Three‐dimensional genome structure and function

MedComm, 2023
Linear DNA undergoes a series of compression and folding events, forming various three‐dimensional (3D) structural units in mammalian cells, including chromosomal territory, compartment, topologically associating domain, and chromatin loop.
Hao Liu, Hsiangyu Tsai, Maoquan Yang, Guozhi Li, Qian Bian, Gang Ding, Dandan Wu, Jiewen Dai   +7 more
doaj   +1 more source

Lamin C is required to establish genome organization after mitosis

Genome Biology, 2021
Background The dynamic 3D organization of the genome is central to gene regulation and development. The nuclear lamina influences genome organization through the tethering of lamina-associated domains (LADs) to the nuclear periphery.
Xianrong Wong, Victoria E. Hoskins, Ashley J. Melendez-Perez, Jennifer C. Harr, Molly Gordon, Karen L. Reddy   +5 more
doaj   +1 more source

Quantifying conformational heterogeneity of 3D genome organization in fruit fly. [PDF]

PLoS One
Abstract The three-dimensional (3D) organization of interphase chromatin in eukaryotes is complex; details of the corresponding genome structures vary stochastically from cell to cell. Here, we propose a metric to quantify the cell-to-cell heterogeneity of the 3D chromatin conformations in ensembles of single cells:
Mali S, Tolokh IS, Cross E, Onufriev AV.
europepmc   +6 more sources

Erratum: Organization and function of the 3D genome [PDF]

Nature Reviews Genetics, 2016
Nature Reviews Genetics 17, 661–678 (2016) In the original version of this article, the statement that CCCTC-binding factor (CTCF) is conserved in most bilaterians was incorrectly referenced. Reference 58 has now been corrected in the online version of the article to cite Heger, P., Marin, B., Bartkuhn, M.
Boyan Bonev, Giacomo Cavalli
openaire   +1 more source

Comparative 3D genome architecture in vertebrates

BMC Biology, 2022
Background The three-dimensional (3D) architecture of the genome has a highly ordered and hierarchical nature, which influences the regulation of essential nuclear processes at the basis of gene expression, such as gene transcription.
Diyan Li, Mengnan He, Qianzi Tang, Shilin Tian, Jiaman Zhang, Yan Li, Danyang Wang, Long Jin, Chunyou Ning, Wei Zhu, Silu Hu, Keren Long, Jideng Ma, Jing Liu, Zhihua Zhang, Mingzhou Li   +15 more
doaj   +1 more source

3DIV update for 2021: a comprehensive resource of 3D genome and 3D cancer genome

, 2021
Three-dimensional (3D) genome organization is tightly coupled with gene regulation in various biological processes and diseases. In cancer, various types of large-scale genomic rearrangements can disrupt the 3D genome, leading to oncogenic gene ...
M Kim, M S Kim, I Jung, Insu Jang, K Kim, J Choi, Byungwook Lee   +6 more
core   +1 more source

Role of lamins in 3D genome organization and global gene expression

Nucleus, 2019
Genome-wide mapping of lamin-B1-genome interactions has shown that gene-poor and transcriptionally inactive genomic regions are associated with the nuclear lamina.
Youngjo Kim, Xiaobin Zheng, Yixian Zheng
doaj   +1 more source