Results 51 to 60 of about 110,305 (278)
Communications Biology, 2021 Kei Fukuda et al. show that the formation of chromatin domains marked by dimethylated H3K9 is functionally linked to the 3D organization of the genome.
Kei Fukuda +7 more
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The Relationship Between 3d Genome Organization And Uv-Induced Dna Damage And Repair [PDF]
, 2023 The three-dimensional (3D) configuration of the eukaryotic genome is essential for myriad cellular processes, such as the modulation of gene expression and the orchestration of epigenetic regulation, as well as the preservation of genome integrity ...
Akköse, Ümit
core
Computational Methods for Multi-Species Comparison of 3D Genome Organization and Function
, 2023 Recent developments in chromatin interaction mapping technologies have greatly advanced the study of higher-order genome organization in the three-dimensional (3D) cell nucleus, which is of vital importance to fundamental genome functions such as DNA ...
Yang Yang (4935544)
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PLoS Genetics, 2020 Membraneless pericentromeric heterochromatin (PCH) domains play vital roles in chromosome dynamics and genome stability. However, our current understanding of 3D genome organization does not include PCH domains because of technical challenges associated ...
Yuh Chwen G Lee +7 more
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Open for connections: HiCAR reveals the interactions of accessible DNA
Cell Genomics, 2022 Hi-C is a powerful technology for exploring 3D genome organization on a genome-wide scale, yet it can be financially and computationally challenging. In a recent issue of Molecular Cell, Wei et al.1 introduce HiCAR, which simplifies Hi-C by targeting the
Benoit Moindrot, Daan Noordermeer
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The 3D Genome: From Structure to Function
, 2021 The genome is the most functional part of a cell, and genomic contents are organized in a compact three-dimensional (3D) structure. The genome contains millions of nucleotide bases organized in its proper frame. Rapid development in genome sequencing and
Ahmed Al-Harrasi +2 more
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3D Genome Engineering: Current Advances and Therapeutic Opportunities in Human Diseases
ResearchDynamic chromatin 3-dimensional (3D) conformation is a key mechanism regulating gene expression and cellular function during development and disease.
Xing Jiang +4 more
doaj +1 more source
Modeling and analysis of spatial genome organization
, 2019 Development of chromosome conformation capture (3C) and its derivative techniques such as Hi-C and ChIA-PET allow to capture the details of the genome organization on multiple scales and led to many new insights into the mechanisms of genome functioning.
SZALAJ, Przemek
core +1 more source
3D nuclear organization and genomic instability in cancer [PDF]
BMC Proceedings, 2013 To understand the genetic changes that occur at tumor initiation and during tumor progression, we focus on changes in nuclear architecture that promote the onset of genomic instability [1,2]. To determine changes in nuclear organization, we measure the 3D nuclear organization of telomeres, the ends of chromosomes.
openaire +3 more sources
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source