Results 71 to 80 of about 4,825,767 (247)

Modeling and analysis of spatial genome organization

, 2019
Development of chromosome conformation capture (3C) and its derivative techniques such as Hi-C and ChIA-PET allow to capture the details of the genome organization on multiple scales and led to many new insights into the mechanisms of genome functioning.
SZALAJ, Przemek
core   +1 more source

Allele-specific control of replication timing and genome organization during development [PDF]

, 2018
DNA replication occurs in a defined temporal order known as the replication-timing (RT) program. RT is regulated during development in discrete chromosomal units, coordinated with transcriptional activity and 3D genome organization.
Dimond, AM
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Structural Modeling of Chromatin Integrates Genome Features and Reveals Chromosome Folding Principle

Scientific Reports, 2017
How chromosomes fold into 3D structures and how genome functions are affected or even controlled by their spatial organization remain challenging questions. Hi-C experiment has provided important structural insights for chromosome, and Hi-C data are used
Wen Jun Xie, Luming Meng, Sirui Liu, Ling Zhang, Xiaoxia Cai, Yi Qin Gao   +5 more
doaj   +1 more source

Acquisition, Modélisation, Préservation, Usages, ... des données 3D​: les challenges du Consortium 3D SHS

, 2020
"Le Consortium 3D SHS, labellisé en 2014 puis en 2018 par la TGIR Huma-Num, a pour vocation de fédérer les initiatives foisonnantes autour de la 3D pour les Sciences Humaines et Sociales pour définir des standards et des recommandations d'usage ainsi que
Consortium 3D SHS Team
core  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Les rencontres du Consortium 3D SHS Création -Usage scientifique - Conservation des données 3D

, 2020
La multiplication des initiatives autour de la création, des usages et de la conservation des données 3D dans les sciences humaines et sociales montrent une réelle nécessité de se coordonner afin de définir des standards dans les usages, les ...
Consortium 3D SHS Team
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Poste en photogrammétrie et modélisation 3D ( LabEx Archimede/CFEETK)

, 2021
"Appel à candidatures du LabEx Archimede et de la Fondation Universitaire Hiérolexique (Université Paul Valéry – Montpellier 3) pour un CDD d’Ingénieur-e d’études en photogrammétrie et modélisation 3D auprès de l’USR 3172 du CNRS - CFEETK, à Karnak....
Consortium 3D SHS Team
core