Results 91 to 100 of about 110,305 (278)

An integrated multi-omics and network analysis of neutrophil differentiation from initial- to late-stage

Genome Biology
Background Neutrophil differentiation is a well-orchestrated process that involves coordinated changes in the chromatin accessibility, transcription factor (TF) binding, 3D genome-structure and transcription.
Qing Chen, Tianchang Yang, Yingping Hou, Kai Wang, Tingting Li, Longteng Wang, Cuiyun Dou, Panpan Cheng, Minglei Shi, Wei Li   +9 more
doaj   +1 more source

NanoLoop: A Deep Learning Framework Leveraging Nanopore Sequencing for Chromatin Loop Prediction

Advanced Science
Chromatin loops play a crucial role in gene regulation and cellular function, providing key insights into understanding the 3D structure of the genome and its impact on cellular homeostasis.
Wenjie Huang, Li Tang, Matthew C. Hill, Yonghao Zhang, Jun Xie, Min Li   +5 more
doaj   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Structural Modeling of Chromatin Integrates Genome Features and Reveals Chromosome Folding Principle

Scientific Reports, 2017
How chromosomes fold into 3D structures and how genome functions are affected or even controlled by their spatial organization remain challenging questions. Hi-C experiment has provided important structural insights for chromosome, and Hi-C data are used
Wen Jun Xie, Luming Meng, Sirui Liu, Ling Zhang, Xiaoxia Cai, Yi Qin Gao   +5 more
doaj   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

3D organization of synthetic and scrambled chromosomes

, 2017
International audienceAlthough the design of the synthetic yeast genome Sc2.0 is highly conservative with respect to gene content, the deletion of several classes of repeated sequences and the introduction of thousands of designer changes may affect ...
Mozziconacci, Julien, Yuan, Ying-Jin, Junbiao Dai, Weimin Zhang, Vittore F. Scolari, Cai, Yizhi, Guillaume Mercy, Kun Yang, Walker, Roy, Leslie A. Mitchell, Mercy, Guillaume, Julien Mozziconacci, Jef D. Boeke, Romain Koszul, Wu, Yi, Luo, Yisha, Michael Shen, Zhang, Weimin, Shen, Michael, Roy Walker, Yang, Huanming, Cai, Yizhi; id_orcid, Ze-xiong Xie, Yang, Kun, Shen, Yue, Dai, Junbiao, Bader, Joel S, Héloïse Muller, Scolari, Vittore F, Huanming Yang, Yue Shen, Luo, Zhouqing, Guanghou Zhao, Thierry, Agnès, Agnès Thierry, Yisha Luo, Ying-Jin Yuan, Joel S. Bader, Zhouqing Luo, Koszul, Romain, Yi Wu, Zhao, Guanghou, Boeke, Jef D, Muller, Héloïse, Luo, Yi, Yizhi Cai, Xie, Ze-Xiong, Mitchell, Leslie A   +47 more
core   +1 more source

The 3D Genome in Transcriptional Regulation and Pluripotency [PDF]

, 2014
It can be convenient to think of the genome as simply a string of nucleotides, the linear order of which encodes an organism’s genetic blueprint. However, the genome does not exist as a linear entity within cells where this blueprint is actually utilized.
Leung, Danny, Gorkin, David U., Ren, Bing, Gorkin, David U   +3 more
core   +1 more source

3DIV update for 2021: a comprehensive resource of 3D genome and 3D cancer genome

, 2021
Three-dimensional (3D) genome organization is tightly coupled with gene regulation in various biological processes and diseases. In cancer, various types of large-scale genomic rearrangements can disrupt the 3D genome, leading to oncogenic gene ...
M Kim, M S Kim, I Jung, Insu Jang, K Kim, J Choi, Byungwook Lee   +6 more
core   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

The Effect of Nuclear Perturbations on the 3D Organization of the Genome

, 2020
Cells in our body experience constant mechanical forces that influence biological functions such as growth and development. The nucleus has been implicated as a key mechanosensor and can directly influence chromatin organization and epigenetic ...
Golloshi, Rosela
core