Results 101 to 110 of about 110,305 (278)

3D-FISH analysis of the spatial genome organization in skin cells in situ

, 2020
NoSpatial genome organization in the cell nucleus plays a crucial role in the control of genome functions. Our knowledge about spatial genome organization is relying on the advances in gene imaging technologies and the biochemical approaches based on the
Fessing, Michael Y., Andrei N. Mardaryev, Mardaryev, Andrei N., Michael Y. Fessing   +3 more
core   +1 more source

Human Gut Bacteria and Lipidic Nanoparticles: Particle Composition Predicts Structural Transformation and Bacterial Biocompatibility

Advanced Functional Materials, EarlyView.
Lipidic nanoparticles (LNPs) were incubated with 21 gut bacteria frequently associated with the human microbiome. SAXS revealed that ∼75% of tested species induced structural transformations in monoolein LNPs, whereas phytantriol and phospholipid formulations remained unaffected.
Jonathan Caukwell, Emily L. Gulliver, Livia Salvati Manni, Frithjof Herb, Caitlin Welsh, Samuel C. Forster, Andrew J. Clulow, Wye‐Khay Fong   +7 more
wiley   +1 more source

3D or Not 3D: Shaping the Genome during Development

, 2021
One of the most fundamental questions in developmental biology is how one fertilized cell can give rise to a fully mature organism and how gene regulation governs this process.
Mundlos, S., Glaser, J.
core   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

The 3D Genome Browser: a web-based browser for visualizing 3D genome organization and long-range chromatin interactions

, 2017
Recent advent of 3C-based technologies such as Hi-C and ChIA-PET provides us an opportunity to explore chromatin interactions and 3D genome organization in an unprecedented scale and resolution.
Yanli Wang, Mayank NK Choudhary, Ming Hu, Lijun Zhang, Ross Hardison, Lin An, Daofeng Li, Bo Zhang, Yun Li, Ting Wang, Feng Yue, Jie Xu   +11 more
core   +1 more source

Swelling‐Programmed Topographical Guidance for Dynamic Spheroid Self‐Assembly via a Mechanochemical Hydrogel Niche

Advanced Functional Materials, EarlyView.
A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam, Seon Yeong Chae, Young Woo Kwon, Hye Jin Heo, Hye Rin Lee, Ji Hyeok Lee, Dong‐Wook Han, Yun Hak Kim, Suck Won Hong   +8 more
wiley   +1 more source

Excessive DNA Double‐Strand Breaks–Associated 3D Genome Reorganization Contributes to Neural Tube Defects with Folate Deficiency

Advanced Science
Neural tube defects (NTDs) are one of the most common congenital malformations. Folic acid deficiency in pregnant women increases the risk of developing NTDs; however, the underlying etiology and mechanisms remain elusive.
Ting Zhang, Lin Lin, Jianting Li, Caihua Li, Shengjun Liang, Xuemei Bai, Fang Wang, Yihua Bao, Dan Guo, Xiaochen Bo, Hao Li, Hebing Chen, Qiu Xie   +12 more
doaj   +1 more source

Heat stress-induced transposon activation correlates with 3D chromatin organization rearrangement in Arabidopsis

Nature Communications, 2020
Heat stress can activate heterochromatin-associated transposon elements (TEs). Here, the authors show that heat stress leads to global rearrangement of 3D genome and TEs activation closely correlates with 3D chromatin organization rearrangement in ...
Linhua Sun, Yuqing Jing, Xinyu Liu, Qi Li, Zhihui Xue, Zhukuan Cheng, Daowen Wang, Hang He, Weiqiang Qian   +8 more
doaj   +1 more source

Genome wide nucleosome landscape shapes 3D chromatin organization

The hierarchical chromatin organization begins with formation of nucleosomes, which fold into chromatin domains punctuated by boundaries and ultimately chromosomes. In a hierarchal organization, lower levels shape higher levels.
Dar, Mohmmad Abaas, Altaf, Mohammad, Krietenstein, Nils, Fouziya, Shah, Baba, Aemon, Khan, Masood A., Mir, Ulfat Syed, Mieczkowski, Jakub, Wani, Ajazul H.   +8 more
core   +1 more source

Engineering 3D genome organization [PDF]

Cell Research, 2018
Xiaowen Lyu, Victor G. Corces
openaire   +2 more sources