Results 81 to 90 of about 110,305 (278)

EPIGENETIC DETERMINANTS OF HETEROCHROMATIC 3D GENOME ORGANIZATION

The role of DNA positioning in three-dimensional (3D) space as a regulator of gene expression and genome function is an open area of investigation. Prior studies have reported correlations between chromatin states and 3D genome organization; however, the
Stutzman, Alexis Victoria
core   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

New insights into 3D chromatin organization and function [PDF]

, 2022
Precise and delicate 3D genome organization is fundamental to cellular homeostasis. Big data generated by high-throughput technologies has granted great opportunities to deepen our understanding of chromatin organization and function, particularly for ...
Zheng, Lina
core  

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Dynamic Changes in DNA Replication Timing and 3D Genome Organization During Cardiac Differentiation

, 2023
University of Minnesota M.S. thesis. March 2023. Major: Biochemistry, Molecular Bio, and Biophysics. Advisor: Juan Carlos Rivera-Mulia. 1 computer file (PDF); vii, 35 pages.Genome architecture has emerged as a key factor of gene regulation and is tightly
Martinez Cifuentes, Santiago
core  

CTCF-Mediated Human 3D Genome Architecture Reveals Chromatin Topology for Transcription. [PDF]

, 2015
Spatial genome organization and its effect on transcription remains a fundamental question. We applied an advanced chromatin interaction analysis by paired-end tag sequencing (ChIA-PET) strategy to comprehensively map higher-order chromosome folding and ...
Liu, Edison, Zhu, Jacqueline Jufen, Ruan, Yijun, Luo, Oscar Junhong, Zhu, Jacqueline,, Wang, Danjuan, Piecuch, Emaly, Tang, Zhonghui, Sachs, Laurent, Jufen Zhu, Jacqueline, Wei, Chia-Lin, Plewczynski, Dariusz, Luo, Oscar,, Zhongyuan Tian, Simon, Zheng, Meizhen, Michalski, Paul, Wilczynski, Grzegorz M, Wilczynski, Grzegorz M., Wilczynski, Grzegorz,, Liu, Edison T., Liu, Edison T, Tian, Simon,, Wlodarczyk, Jakub, Szala, Przemyslaw, Wang, Ping, Sachs, Laurent M, Trzaskoma, Pawel, Tian, Simon Zhongyuan, Ruan, Xiaoan, Sachs, Laurent M., Ruszczycki, Blazej, We, Chia-Lin, Szalaj, Przemyslaw, Li, Xingwang, Li, Guoliang, Magalska, Adriana, Penrad-Mobayed, May   +36 more
core   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source