Results 81 to 90 of about 5,043,774 (177)

Excessive DNA Double‐Strand Breaks–Associated 3D Genome Reorganization Contributes to Neural Tube Defects with Folate Deficiency

Advanced Science
Neural tube defects (NTDs) are one of the most common congenital malformations. Folic acid deficiency in pregnant women increases the risk of developing NTDs; however, the underlying etiology and mechanisms remain elusive.
Ting Zhang, Lin Lin, Jianting Li, Caihua Li, Shengjun Liang, Xuemei Bai, Fang Wang, Yihua Bao, Dan Guo, Xiaochen Bo, Hao Li, Hebing Chen, Qiu Xie   +12 more
doaj   +1 more source

Heat stress-induced transposon activation correlates with 3D chromatin organization rearrangement in Arabidopsis

Nature Communications, 2020
Heat stress can activate heterochromatin-associated transposon elements (TEs). Here, the authors show that heat stress leads to global rearrangement of 3D genome and TEs activation closely correlates with 3D chromatin organization rearrangement in ...
Linhua Sun, Yuqing Jing, Xinyu Liu, Qi Li, Zhihui Xue, Zhukuan Cheng, Daowen Wang, Hang He, Weiqiang Qian   +8 more
doaj   +1 more source

Genome wide nucleosome landscape shapes 3D chromatin organization

The hierarchical chromatin organization begins with formation of nucleosomes, which fold into chromatin domains punctuated by boundaries and ultimately chromosomes. In a hierarchal organization, lower levels shape higher levels.
Dar, Mohmmad Abaas, Altaf, Mohammad, Krietenstein, Nils, Fouziya, Shah, Baba, Aemon, Khan, Masood A., Mir, Ulfat Syed, Mieczkowski, Jakub, Wani, Ajazul H.   +8 more
core   +1 more source

The 3D Genome Browser: a web-based browser for visualizing 3D genome organization and long-range chromatin interactions

, 2017
Recent advent of 3C-based technologies such as Hi-C and ChIA-PET provides us an opportunity to explore chromatin interactions and 3D genome organization in an unprecedented scale and resolution.
Yanli Wang, Mayank NK Choudhary, Ming Hu, Lijun Zhang, Ross Hardison, Lin An, Daofeng Li, Bo Zhang, Yun Li, Ting Wang, Feng Yue, Jie Xu   +11 more
core   +1 more source

Engineering 3D genome organization [PDF]

Cell Research, 2018
Xiaowen Lyu, Victor G. Corces
openaire   +2 more sources

3D HOP

, 2020
" 3DHOP (3D Heritage Online Presenter) is an open-source software package for the creation of interactive Web presentations of high-resolution 3D models, oriented to the Cultural Heritage field....
Consortium 3D SHS Team
core  

Inter-chromosomal transcription hubs shape the 3D genome architecture of African trypanosomes

Nature Communications
The eukaryotic nucleus exhibits a highly organized 3D genome architecture, with RNA transcription and processing confined to specific nuclear structures. While intra-chromosomal interactions, such as promoter-enhancer dynamics, are well-studied, the role
Claudia Rabuffo, Markus R. Schmidt, Prateek Yadav, Pin Tong, Roberta Carloni, Anna Barcons-Simon, Raúl O. Cosentino, Stefan Krebs, Keith R. Matthews, Robin C. Allshire, T. Nicolai Siegel   +10 more
doaj   +1 more source

Revealing Hi-C subcompartments by imputing inter-chromosomal chromatin interactions

Nature Communications, 2019
Genome-wide mapping of chromatin interactions reveals various levels of 3D genome organization. Here, the authors develop SNIPER, a computational method for identifying subcompartments using Hi-C data with moderate coverage.
Kyle Xiong, Jian Ma
doaj   +1 more source

3D genome organization in brown algae

The three-dimensional (3D) organization of the genome plays a crucial role in gene regulation and epigenetic states. In animal genomes, core 3D genome features like topologically associated domains (TADs) and chromatin loops have been extensively characterized, whereas in plants such higher order structures are less pronounced.
openaire   +3 more sources

Implications of the three-dimensional chromatin organization for genome evolution in a fungal plant pathogen

Nature Communications
The spatial organization of eukaryotic genomes is linked to their biological functions, although it is not clear how this impacts the overall evolution of a genome.
David E. Torres, H. Martin Kramer, Vittorio Tracanna, Gabriel L. Fiorin, David E. Cook, Michael F. Seidl, Bart P. H. J. Thomma   +6 more
doaj   +1 more source